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HUGH SALZBERG SEMINAR SERIES

  • Date
    Mon, Sep 30

    Time
    12:00 PM — 1:00 PM

    Address
    MARSHAK
    160 CONVENT AVE

    Location
    MARSHAK, 1027

    p: 212.650.8402

    Admission
    Free

  • Event Details

    . Biologically Inspired Microsystems for Achieving Physiological Stasis

    Abstract: Three vignettes of on-going research will be used to illustrate the concept of measurement and feedback control to achieve physiological stasis. The first of these is the development of a minimally invasive implantable point-of-care (POC) bioanalytical microsystem for rapid deployment and continual monitoring of intramuscular glucose and lactate via dual responsive amperometric enzyme biosensors. This engineered microsystem is being developed for use by first responders to allow multi-analyte monitoring of key metabolites of hemodynamic stress for the management of trauma-induced hemorrhage. Here feedback control is via the trauma physician. The second is the development of biologically responsive hydrogel microspheres for the delivery of drugs that serve to modulate the release profile via molecular feedback control. This engineered material system is being developed for the treatment of chronic wounds and exploits the elevated levels of matrix metalloproteinases (MMPs) to cleave a tethered peptide that is conjugated to an MMP inhibitor. The inhibitor once released, modulates MMP to targeted activity levels within the chronic wound environment. The third of these is the synthesis of functionalized carbon nanotubes used in direct biosensors, advanced biofuel cells and electronic noses. Here, direct electron transfer between the carbonaceous materials and the metallic electrode allows for array sensing and/or control of enzyme activity. These three systems each encompass the notion of integration of the measurement of a gap between an actual and a reference level and a mechanism to close that gap via feedback – a control loop. These systems are integrated, the first at the level of discrete sub-systems acting through an operator, the second at the level of molecular events acting through molecular phenomena of mass transport and reaction kinetics, and the third at the level of electronic transport and redox events.
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