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Biochemistry Seminar:  Frank Robb

  • Date
    Wed, Oct 30

    Time
    12:00 PM — 1:00 PM

    Website
    http://forum.sci.ccny.cuny.edu/administration/chemistry/events

    Address
    Marshak
    160 Convent Avenue

    Location
    Marshak, MR-1027

    p: 212.650.8803

    Admission
    Free

  • Event Details

    Frank Robb will give a talk titled "Phylogeny and Mechanism for Stabilizing the Chaperonin, Cpn60."

    Frank Robb, Professor, Institute of Marine & Environmental Technology, Dept of Microbiology & Immunology, University of Maryland School of Medicine, will give a talk titled, "Phylogeny and Mechanism for Stabilizing the Chaperonin, Cpn60."

    ABSTRACT
    Chaperonins are universal proteins that are critical for cell survival, especially in extreme thermophiles. A longstanding convention divides Cpns into two groups that share many conserved sequence motifs but differ in both subunit structure and distribution. We discovered a third, distinct group of Cpn in divergent species of bacteria. We propose to name these as Group III Cpns because of their distant relatedness to both group I and II Cpns. The Group III lineage may represent a progenitor of the group II CPNs. (Techtmann and Robb, 2011).

    We have been studying the structural basis of intrinsic stability of Group II Cpn60 chaperonins.  We discovered that a highly charged C terminal domain determines the stability and themoactivity of Cpn60  in thermophiles (Luo et al, 2011). The mechanism of thermostabilization and the action of chaperonins is considerably simpler in Archaea than in Eukarya, particularly in hyperthermophiles suggesting that the former could represent a model system for eukaryotic chaperonins.

    References
    Techtmann, S,  F.T. Robb (2010) Archaeal-like chaperones in bacteria. Proc. Natl. Acad. Sci USA. 107 (47) 20269- 20274.

    Luo, H,  Robb FT. (2011) A modulator domain controlling thermal stability in the Group II chaperonins of Archaea. Arch Biochem Biophys. 512(1):111-8.
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