Protein Assembly and Disassembly to Create Therapeutic Materials
Mon, May 05
2:00 PM — 3:15 PM
Steinman Hall 160 - Lecture Hall
The ChE Department would like to welcome Julie Champion from the Georgia Institute of TechnologyAbstract:
Protein drugs can provide a key advantage over small molecule drugs; they evolved to perform their function, while small molecules are often selected for “best” function compared to a pool of candidates. However, proteins can present challenges in delivery that must be overcome in order to be used as therapeutic drugs. Though their folded structure is critical to their biological function and makes them sensitive and difficult to package, this structure also provides an opportunity to create materials from them that is not available for small molecules. The main goal of our work is to engineer materials made from therapeutic proteins and is accomplished through a combination of self-assembly and bio-conjugation processes. The ability to control these processes is essential to manipulating material physical properties, ensuring retention of protein activity, and directing the interactions between the materials and cells. The strategies developed here provide opportunities to work with unlikely proteins, such as those from pathogenic bacteria, and engineer them from disease causing agents into beneficial therapeutic materials. Protein design, self-assembly and disassembly properties, and applications of therapeutic proten materials in cancer, inflammation and vaccines will be discussed.
Julie Champion is an Assistant Professor in the School of Chemical & Biomolecular Engineering at Georgia Institute of Technology and a member of the Institute for Bioengineering and Biosciences and the Bioengineering Program. She earned her B.S.E. in Chemical Engineering from the University of Michigan in 2001. Dr. Champion completed her Ph.D. in Chemical Engineering at the University of California Santa Barbara in 2007 as a National Science Foundation graduate fellow with Prof. Samir Mitragotri. She was a National Institutes of Health postdoctoral fellow from 2007-2009 at the California Institute of Technology in the lab of Prof. David Tirrell. Professor Champion’s current research focuses on design and self-assembly of therapeutic nanomaterials made from engineered proteins for applications in cancer and immunology. Dr. Champion has received a BRIGE award from the National Science Foundation and the Georgia Tech Women in Engineering Faculty Award for Excellence in Teaching.