Biochemistry Seminar: Debra Auguste
Wed, Apr 02
12:00 PM — 1:00 PM
MarshakCity College of New York160 Convent Ave
Marshak, Marshak, MR 1027
Debra Auguste, City College of New York, "Personalized Therapeutics"Debra Auguste, Assoc Prof., Dept of Biomed Eng, City College of New York, will give a talk on "Personalized Therapeutics"
Metastatic breast cancers (MBCs) have high mortality owing to aggressive proliferation and metastasis and a lack of diversified treatment options. Epidemiological studies support differences in MBC behavior by age, ethnicity, and BRCA1 gene status. Our quantitative investigation of cell membrane surface chemistry in cell lines and human tissues has led to the design of a series of personalized therapeutics. Additionally, we focus on intervention in multiple pathways to simultaneously reduce metastasis and proliferation. Our synergistic approach - coupling cell chemistry and cell behavior - may transform how we think and design therapeutics. In addition to our efforts in drug delivery, we will show how responsive materials may be designed to regenerate tissue. Our in vitro, in vivo, and in silico results demonstrate that bioresponsive materials can induce a pro-healing response.