Biochemistry Seminar: Susan Smith, NYU Langone Medical Center
Wed, Mar 19
12:00 PM — 1:00 PM
MarshakCity College of New York160 Convent Ave
Marshak, MR 1027
Susan Smith, Prof., will give a talk on "The role of telomere cohesion in aging cells and cancer"Susan Smith, Professor, Dept of Pathology & Molecular Pathogenesis, NYU Langone Medical Center, "The role of telomere cohesion in aging cells and cancer"
Telomeres require specialized mechanisms for their replication, protection, and cohesion. Establishment of sister chromatid cohesion during DNA replication is essential for homologous recombination and DNA repair and timely resolution of cohesion at mitosis is critical for genome integrity. Resolution of telomere cohesion in human cells relies on the poly(ADP-ribose) polymerase tankyrase 1 that localizes to telomeres in late G2/early mitosis to resolve cohesion and allow progression through mitosis. We have recently discovered that this “normal” system of telomere resolution is corrupted in aging cells and in a special type of tumor cell termed ALT that uses a recombination-based mechanism for telomere maintenance. I will present experiments that elucidate the underlying mechanism for the persistent cohesion observed in aging and ALT cells. Our studies suggest that keeping the sister in close proximity into mitosis promotes the recombination between sister telomeres that is required for telomere maintenance and cell survival in aging cells and in ALT cancer cells.