Salzberg Chemistry Seminar: Prof. Seth Herzon
Mon, Feb 11
12:00 PM — 1:00 PM
MR160 Convent Avenue
Prof. Seth Herzon, Yale University: "Target Driven Total Synthesis"Abstract
Natural products total synthesis provides a rich and unparalleled opportunity to develop new synthetic transformations, conceive novel and general strategies to access complex structures, and study the mechanism of action of bioactive targets. We have recently developed a general, unified pathway to synthesize the hasubanan and acutumine alkaloids, a large family of polycyclic botanical natural products. Our strategy to access these targets, and the total syntheses of six members of this family, will be presented. In addition, we have developed a general and versatile route to prepare complex diazofluorenes, an unusual functional group found in the antiproliferative metabolites known as the kinamycins and lomaiviticins. Applications of this chemistry towards the syntheses of kinamycin F and lomaiviticin aglycon, and elucidation of the mechanism of action of lomaiviticin A, will be presented.