Salzberg Chemistry Seminar: Prof. Seth Herzon

• Date
  Mon, Feb 11

  Time
  12:00 PM — 1:00 PM

  Website
  http://www1.ccny.cuny.edu/prospective/science/chemistry/index.cfm

  Address
  MR
  160 Convent Avenue
  

  Location
  MR, 1027

  p: 212.650.8402

  Admission
  Free

• Event Details

  Prof. Seth Herzon, Yale University: "Target Driven Total Synthesis"

  Abstract
  Natural products total synthesis provides a rich and unparalleled opportunity to develop new synthetic transformations, conceive novel and general strategies to access complex structures, and study the mechanism of action of bioactive targets.  We have recently developed a general, unified pathway to synthesize the hasubanan and acutumine alkaloids, a large family of polycyclic botanical natural products.  Our strategy to access these targets, and the total syntheses of six members of this family, will be presented.  In addition, we have developed a general and versatile route to prepare complex diazofluorenes, an unusual functional group found in the antiproliferative metabolites known as the kinamycins and lomaiviticins.  Applications of this chemistry towards the syntheses of kinamycin F and lomaiviticin aglycon, and elucidation of the mechanism of action of lomaiviticin A, will be presented.