IUSL Interdisciplinary Seminar

• Date
  Thu, Feb 21

  Time
  2:00 PM — 3:00 PM

  Website
  http://www.1.ccny.cuny.edu/ci/iusl

  Address
  Marshak
  City College of New York
  Physics Department
  

  Location
  Marshak, 418N

  p: 5531

  Admission
  Free

• Event Details

  What Does Aquaporin-1 Have To Do With Early Atherosclerosis?
  
  Prof. David S. Rumschitzki

  Prof. Rumschitzki will explain the earliest events in the processes that lead, over a period of decades, to the clogging of arteries. This sequence appears to begin with the transport of large (20-25 nm) low density lipoprotein (LDL) cholesterol particles from the blood across the (endothelial) lining of the artery wall and into the wall’s inner layers, where the LDL may bind to extracellular matrix or efflux from the wall. This process turns out to be dominated by advection, meaning the blood-pressure-driven flow of water and small solutes from the blood across the porous vessel wall can carry these LDL particles through rare, focal endothelial leaky sites. Once inside the wall the overall water flow through the wall can carry these LDL particles through the wall. Endothelial cells are important markers in blood of heart attached.