IUSL Interdisciplinary Seminar
Thu, Feb 21
2:00 PM — 3:00 PM
MarshakCity College of New YorkPhysics Department
What Does Aquaporin-1 Have To Do With Early Atherosclerosis?Prof. Rumschitzki will explain the earliest events in the processes that lead, over a period of decades, to the clogging of arteries. This sequence appears to begin with the transport of large (20-25 nm) low density lipoprotein (LDL) cholesterol particles from the blood across the (endothelial) lining of the artery wall and into the wall’s inner layers, where the LDL may bind to extracellular matrix or efflux from the wall. This process turns out to be dominated by advection, meaning the blood-pressure-driven flow of water and small solutes from the blood across the porous vessel wall can carry these LDL particles through rare, focal endothelial leaky sites. Once inside the wall the overall water flow through the wall can carry these LDL particles through the wall. Endothelial cells are important markers in blood of heart attached.
Prof. David S. Rumschitzki