Division of Social ScienceDepartment
Jon Horvitz's laboratory exaamines the neurobiological underpinnings of learning and motivation. Specifically, their work examines the role of dopamine and brain regions receiving dopamine input (nucleus accumbens, dorsal striatum) in reward-related learning.
BA: Haverford College, 1985, Neuropsychology, magna cum laude.
Ph.D. : University of California, Santa Barbara, 1991, Psychology.Dissertation Title: The role of central dopamine systems in reinforcement and motor processes.
Post doc: Princeton University Program in Neuroscience, 1992-1995, Single-unit studies of midbrain dopamine neurons in freely-moving animals
Brain, Mind, Experience, PSY254
Advanced Topics in the Neurochemistry of Learning, PSY31114
Ashby, F. G., Turner, B. O., & Horvitz, J. C. Cortical and basal ganglia contributions to habit learning and automaticity. Trends Cogn Sci, 14, 208-15, 2010.
Choi, W., Morvan, C., Balsam, P.D., Horvitz, J.C. Dopamine D1 and D2 antagonist effects on response likelihood and duration. Behavioral Neuroscience, 123, 1279-87, 2009.
Horvitz, J.C. Stimulus-response and response-outcome learning mechanisms in the striatum. Behavioral Brain Research, 199, 129-40, 2009.
Wickens, J., Horvitz, J.C., Costa, R., Killcross, S. Dopaminergic Mechanisms in Actions and Habits, Journal of Neuroscience, 27, 8181-3, 2007.
Horvitz, J.C., Choi, W., Morvan, C., Eyny, Y. Balsam, P.D. A "Good Parent" function of dopamine: transient modulation of learning and performance during early stages of training. New York Academy of Sciences, 1104, 270-288, 2007.
Taylor, K.M., Horvitz, J.C., Balsam, P.D. Amphetamine affects the start of responding in the peak interval timing task, Behav Processes, 74, 168-75, 2007
Rick, J.H., Horvitz, J.C., Balsam, P.D. The Effect of Dopamine Receptor Blockade on Behavioral Variability and Comparisons to Extinction, Behavioral Neuroscience, 120, 488-92, 2006.
Horowitz, T.S., Choi, W., Horvitz, J.C., Cote, L.J., Mangels, J.A. Visual search deficits in Parkinson’s disease are attenuated by bottom-up target salience and top-down information, Neuropsychologia, 44, 1962-77, 2006.
Choi, W., Balsam, P.D., Horvitz, J.C. “Extended Habit Training Reduces Dopamine Mediation of Appetitive Response Expression”, Journal of Neuroscience, 25, 6729-33, 2005.
Stern, E.R., Horvitz, J.C., Cote, L.J., Mangels, J.A. Maintenance of Response Readiness in Patients with Parkinson's Disease: Evidence from a Simple Reaction TimeTask, Neuropsychology, 19, 54-65, 2005.
Davidson, M.C., Horvitz, J.C., Tottenham, N., Fossella, J.A., Watts, R., Ulug, A.M., Casey, B.J. Differential Page 8 Cingulate and Caudate Activation Following Unexpected Non-Rewarding Stimuli, NeuroImage, 23, 1039-1045, 2004.
Drew, M., Malpani, C., Horvitz, J.C., Balsam, P.D. Dopamine antagonist effects on the timing of two intervals, Pharmacology, Biochemistry and Behavior, 75, 9-15, 2003.
Eyny, Y.S. and Horvitz, J.C. Opposing roles of D1 and D2 receptors in appetitive conditioning. Journal of Neuroscience, 23, 1584-87, 2003.
Horvitz, J.C. Dopamine, Parkinson’s disease, and volition. Commentary in Behavioral and Brain Sciences,25(5), 586, 2002.
Horvitz, J.C. Dopamine gating of glutamatergic sensorimotor and incentive motivational inputs to the striatum. Behavioral Brain Research, 137, 65-74, 2002.
Horvitz, J.C. The effects of D1 and D2 receptor blockade on the acquisition and expression of a conditionedappetitive response. Appetite, 37, 119-120, 2001.
Ohyama, T., Horvitz, J.C., Kitsos, E., and Balsam, P.D. The role of dopamine in the timing of pavlovian conditioned keypecking in ring doves. Pharmacology Biochemistry and Behavior, 69, 617-627, 2001.
Horvitz, J.C., Williams, G, Joy, R. Time-dependant actions of D2 family agonist quinpirole on components of spontaneous behavior: dissociation between sniffing and locomotion. Psychopharmacology, 154, 350-355, 2001.
Ohyama, T., Horvitz, J.C., Drew, M., Gibbon. J. and Balsam, P.D. Conditioned and unconditioned behavioral/cognitive effects of a dopamine antagonist. Behavioral Neuroscience, 114,1251-1255, 2000.
Horvitz, J.C., and Eyny, Y. Dopamine D2 receptor blockade reduces response likelihood but does not affect latency to emit a learned sensory-motor response: Implications for Parkinson’s disease. Behavioral Neuroscience, 114, 934-939, 2000.
Horvitz, J.C. Mesolimbic and nigrostriatal dopamine responses to salient non-reward events. Neuroscience, 96, 651-656, 2000.
Page 9 Pitts, S.M. & Horvitz, J.C. Similar effects of D1/D2 receptor blockade on feeding and locomotor behavior. Pharmacology, Biochemistry, and Behavior, 65, 433-438, 2000.
Horvitz, J.C., Stewart, T., & Jacobs, B.L. Burst activity of ventral tegmental dopamine neurons is elicited by sensory stimuli in the awake cat. Brain Research, 759, 251-258, 1997.
Horvitz, J.C., Richardson, W.B., & Ettenberg, A. Dopamine receptor blockade and reductions in thirst produce differential effects on drinking behavior. Pharmacology, Biochemistry, and Behavior, 45, 725-728, 1993.
Horvitz, J.C. & Ettenberg, A. Conditioned incentive properties of a food-paired CS remain intact during dopamine receptor blockade. Behavioral Neuroscience, 105, 536-541, 1991.
Ettenberg, A. & Horvitz, J.C. Pimozide prevents the response-reinstating effects of water reinforcement in rats. Pharmacology, Biochemistry, and Behavior, 37, 465-469, 1990.
Horvitz, J.C. & Ettenberg, A. Haloperidol blocks the response-reinstating effects of food reward: A methodology for separating neuroleptic effects on reinforcement and motor processes. Pharmacology, Biochemistry, and Behavior, 31, 861-865, 1989.
Schull, J., McEachron, D.L., Adler, N.J., Fiedler, L., Horvitz, J.C., Noyes,A.,Olson, M., & Shack, J. Effects of thyroidectomy, parathyroidectomy and lithium on circadian wheelrunning in rats. Physiology and Behavior, 42, 33-39, 1988.