Dr. Saleque is interested in delineating the genetic and epigenetic basis of hematopoiesis, the process of blood cell generation. The lab seeks to understand how transcriptional regulation and alteration of the chromatin structure of genes determine the fate and function of stem and progenitor cells and their differentiated progeny during mammalian development. For this purpose, we utilize the mouse as a model experimental organism and tissue culture manipulation of human and mouse cells.
B.Sc. in Chemistry (Major), Calcutta University, India
Biology V5003 - Developmental Biology (Graduate level)
Saleque, S., Kim, J., Rooke, H.M., and Orkin, S.H. 2007. Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Molecular Cell. 27(4): 562-572. http://www.cell.com/molecular-cell/abstract/S1097-2765(07)00483-2
Zhou, J., Saleque, S., Ermakova, O., Sepulveda, M. A., Yang, Q., Eckhardt, L. A., Schildkraut, C. L., and Birshtein, B. K. 2005. Changes in replication, nuclear location, and expression of the Igh locus after fusion of a pre-B cell line with a T cell line. J. Immunol. 175; 2317-20.
Hock, H., Hamblen, M.J., Rooke, H.M., Schindler, J.W., Saleque, S., Fujiwara, Y., Orkin, S.H. 2004. Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature.431: 1002-07. http://www.nature.com/nature/journal/v431/n7011/full/nature02994.html
Gordon, S. J., Saleque, S. and Birshtein, B.K. 2003. Yin Yang 1 (YY1) binding to the 3’ IgH enhancer is induced by class switching and cell cycle progression. J. Immunol. 170: 5549-5557.
Saleque S., Cameron, S. and Orkin,. S.H. 2002. The zinc-finger protooncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages. Genes and Development. 16: 301-306. http://genesdev.cshlp.org/content/16/3/301.full.pdf
Saleque, S., Singh, M. and Birshtein, B.K. 1999. IgH expression and class switching in vitro from an allele lacking the 3' enhancers DNase I hypersensitive sites hs3A and hs1,2. J. Immunol. 162 (5): 2791-2803.
Saleque, S., Singh, M., Little, R.D., Giannini, S.L., Michaelson, J.S. and Birshtein, B. K. 1997. Dyad symmetry within the mouse 3' IgH regulatory region includes two virtually identical enhancers (Calpha3'E and hs3). J. Immunol. 158 (10): 4780-7.
Shrivastava, A., Saleque, S., Kalpana, G.V., Artandi, S., Goff, S. P. and Calame, K. 1993. Inhibition of transcriptional regulator Yin-yang 1 by association with c-myc. Science. 262(5141): 1889-92.
Research Associate: Asif Chowdhury
Rotation Students: Ananya Sengupta, Deepak Menon, Mohammaed Bhuiyan and
Graduate Student: David Kim
Undergraduate student: Shaleen Chakyayil