Division of ScienceDepartment
ProfileProf. Lakshman obtained the PhD degree from the University of Oklahoma and did postdoctoral work as a Fogarty Fellow at the National Institutes of Health (NIDDK). He then took up an industrial position as Senior Scientist before returning to academia 1998. Prof. Lakshman started his academic career at the University of North Dakota before joining CCNY. From 2008-2011, Prof. Lakshman was the Executive Officer for the CUNY PhD program in Chemistry.
EducationB.Sc. University of Bombay
M.Sc. University of Bombay
MS University of Oklahoma
PhD University of Oklahoma
Research InterestsProf. Lakshman's research is in organic chemical synthesis pertaining to questions of biological interest. The program has many facets but can be broadly divided into the following areas.
A. Nucleoside Modifications. Here new metal-catalyzed as well as uncatalyzed routes are being invented, to enable nucleoside modification.
B. Studies on Environmental Pollutants. In this area, structural and biological effects of DNA modification by environmental pollutants are studied. In addition, new chemical methodology to create model systems for studying metabolic activation processes of environmental pollutants are being developed.
C. New Chemical Methodology. New methods to create molecules, and new physiologically important molecules are developed, via new approaches.
Research is conducted with the idea that Fundamental Understanding drives New Chemistry (FUNCy). Thus, development of chemical methodology and synthesis of novel molecules require a sound understanding of mechanistic organic chemistry, as being integral to the research.
PublicationsRepresentative Recent Publications
Gurram, V.; Pottabathini, N.; Garlapati, R.; Chaudhary, A. B.; Patro, B.; Lakshman, M. K.: C-C cross-coupling reactions of O6-alkyl-2-haloinosine derivatives and a one-pot cross-coupling/O6-deprotection procedure, Chemistry-An Asian Journal, 2012, 7, in press.
Kokatla, H. P.; Lakshman, M. K: Two-step, one-pot synthesis of inosine, guanosine, and 2'-deoxyguanosine O6-ethers, Current Protocols in Nucleic Acid Chemistry (John Wiley and Sons, Inc.) 2012, in press.
Lakshman, M. K.; Deb, A.; Chamala, R. R.; Pradhan, P.; Pratap, R.: Direct arylation of 6-phenylpurine and 6-arylpurine nucleosides by ruthenium-catalyzed C-H bond activation, Angewandte Chemie, International Edition 2011, 50, 11400-11404. DOI: 10.1002/anie.201104035
Featured on the inside cover
Kokatla, H. P.; Thomson, P. F.; Bae, S.; Facile reduction of amine N-oxides by diboron compounds, Journal of Organic Chemistry 2011, 76, 7842-7848. DOI: 10.1021/jo201192c
Kokatla, H. P.; Lakshman, M. K.: One-pot etherification of purine nucleosides and pyrimidines, Organic Letters 2010, 12, 4478-4881. DOI: 10.1021/ol101655h
Thomson, P. F.; Lagisetty, P.; Balzarini, J.; De Clercq, E.; Lakshman, M. K.: Palladium-catalyzed aryl amination reactions of 6-bromo and 6-chloropurine nucleosides, Advanced Synthesis and Catalysis 2010, 352, 1728-1735. DOI: 10.1002/adsc.200900728
Kumar, A.; Akula, H. K.; Lakshman, M. K.: Simple synthesis of amides and Weinreb amides using PPh3 or polymer-supported PPh3 and iodine, European Journal of Organic Chemistry 2010, 2709-2715. DOI: 10.1002/ejoc.200901420
Highlighted in Synfacts 2010, #8, 968
Lakshman, M. K.; Singh, M. K.; Parrish, D.; Balachandran, R.; Day, B. W.: Azide-tetrazole equilibrium of C-6 azidopurine nucleosides and their ligation reactions with alkynes, Journal of Organic Chemistry 2010, 75, 2461-2473. DOI: 10.1021/jo902342z
Pratap, R.; Parrish, D.; Gunda, P.; Venkatraman, D. V.; Lakshman, M. K.: Influence of biaryl phosphine structure on C-N and C-C bond formation, Journal of the American Chemical Society 2009, 131, 12240-12249.
Lakshman, M. K.; Frank, J.: A simple method for C-6 modification of guanine nucleosides, Organic and Biomolecular Chemistry 2009, 7, 2933-2940. DOI: 10.1039/B905298D
Featured on the cover of the issue
Singh, M. K.; Lakshman, M. K.: A simple synthesis of nitriles from aldoximes, Journal of Organic Chemistry 2009, 74, 3079-3084. DOI: 10.1021/jo900100v
Among the "Top 20 most downloaded articles for the previous month" (April 2009)
Highlighted in ChemInform 2009, 40, doi: 10.1002/chin.200935087
Bae, S.; Chaturvedi, S.; Lakshman, M. K.: O6-(Benzotriazol-1-yl)inosine derivatives, a new class of compounds for modification at the C-6 of purine nucleosides, Current Protocols in Nucleic Acid Chemistry (John Wiley and Sons, Inc.) 2009, Supplement 36, 1.22.
Lakshman, M. K.; Choudhury, A.; Bae, S.; Rochttis, E.; Pradhan, P.; Kumar, A.: Synthesis of N6,N6-dialkyl adenine nucleosides using hexaalkylphosphorus triamides produced in situ, European Journal of Organic Chemistry, 2009, 152-159. DOI: 10.1002/ejoc.200800752
Additional InformationAwards and Recognitions
The City College of New York President's S.T.A.R. (Service, Teamwork, Action, and Results) Award 2011
"Excellent Service to the Editors and Authors of EurJOC European Journal of Organic Chemistry" Certificate of Recognition from Wiley-VCH and ChemPubSoc Europe
"In Honor of Outstanding Scholarly Achievements to the Creation and Transmittal of Knowledge" Certificate of Recognition from The City University of New York, 2007
Certificate of Appreciation from the Alfred P. Sloan Foundation for "Commitment to Advancing Underrepresented Minority Students in Mathematics, Science and Engineering and for Partnering with the Foundation's Minority Program," 2007
Profiled in the June 1 issue of India Abroad, 2007
"For Securing Major Institutional Grant Funds in 2005" Certificate of Recognition from The City University of New York, 2006
"In Honor of Outstanding Scholarly Achievements to the Creation and Transmittal of Knowledge" Certificate of Recognition from The City University of New York, 2004
"Outstanding Mentor Award" The City College of New York, 2003-2004
"In Honor of Outstanding Scholarly Achievements to the Creation and Transmittal of Knowledge" Certificate of Recognition from The City University of New York, 2002
"In Honor of Outstanding Scholarly Achievements to the Creation and Transmittal of Knowledge" Certificate of Recognition from The City University of New York, 2001
Co-Chair Oral Presentation Session at the 14th International Conference, Lucknow, India, 2010
Editorial Board Member Organic Chemistry International
Editorial Board Member Current Chemical Biology
Editorial Board Member Acta Chimica Slovenica
Ad hoc and Panel Reviewer for The National Institutes of Health, The National Science Foundation, The American Chemical Society Petroleum Research Fund
Reviewer for various national and international journals (for example: Angewandte Chemie, International Edition, Journal of the American Chemical Society, Nature Protocols, Organic Letters, The Journal of Organic Chemistry, The Journal of Medicinal Chemistry, European Journal of Organic Chemistry, Chemical Research in Toxicology, Bioorganic and Medicinal Chemistry, Bioorganic and Medicinal Chemistry Letters, Tetrahedron, Tetrahedron Letters, Synthesis, Synlett)
Executive Officer, The City University of New York PhD Program in Chemistry, July 2008-June 2011
Chair, Masters Program Committee
Chair, Search Committee for a Lecturer in Organic Chemistry
Chair, Search Committee for a Faculty Member in Organic Chemistry
Member, Outstanding Teaching/Mentoring Award Committee
Member, Search Committee for a Faculty Member in Organic Chemistry
Member, Search Committee for Organic and Biochemistry Technicians
Member, Executive Committee of the Chemistry Department
Member, Search Committee for NMR Facility Manager