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Faculty and Staff Profiles

Mark R. Biscoe

Assistant Professor

School/Division

Division of Science

Department

Chemistry

Office

Marshak 1232

p: 212-650-8348

e: mbiscoe@ccny.cuny.edu

  • Education

    Massachusetts Institute of Technology (NIH post-doctoral fellow) 2005-2008

    Columbia University, Ph.D., 2005

    Wesleyan University, B.A., 1999

  • Research Interests

  • Publications

    17. Li, Ling; Biscoe, Mark R. "Alkylzinc Cross-Coupling Reactions." In Cross-Coupling and Heck-Type Reactions, Vol. 1; Molander, G., Ed.; Georg Thieme Verlag HG: Stuttgart, 2012.

    16. Joshi-Pangu, Amruta; Ma, Xinghua; Diane, Mohammed; Iqbal, Sidra; Kribs, Robert J.; Huang, Richard; Wang, Chao-Yuan; Biscoe, Mark R. J. Org. Chem. 2012, 77, 6629-6633.

    15. Joshi-Pangu, Amruta; Biscoe, Mark R.* "The Use of Tertiary Alkyl Nucleophiles in Metal-Catalyzed Cross-Coupling Reactions." Synlett 2012, 23, 1103-1107. [Invited review highlighting work in publication 14]

    14. Joshi-Pangu, Amruta; Wang, Chao-Yuan; Biscoe, Mark R.* “Nickel-Catalyzed Kumada Cross-Coupling Reactions of Tertiary Alkylmagnesium Halides and Aryl Bromides/Triflates.” J. Am. Chem. Soc. 2011, 133, 8478-8481. [Highlighted in: Synfacts 2011, 8, 897]

    13. Joshi-Pangu, Amruta; Ganesh, Madhu; Biscoe, Mark R.* “Nickel-Catalyzed Negishi Cross-Coupling Reactions of Secondary Alkylzinc Halides and Aryl Iodides.” Org. Lett. 2011, 13, 1218-1221. [Highlighted in: Synfacts 2011, 6, 662] 

    12. Biscoe, Mark R.; Buchwald, Stephen L. “The Selective Monoarylation of Acetate Esters and Aryl Methyl Ketones Using Aryl Chlorides.” Org. Lett. 2009, 11, 1773-1775. 

    11. Lee, Brian K.; Biscoe, Mark R.; Buchwald, Stephen L. “Simple, Efficient Protocols for the Pd-Catalyzed Cross-Coupling Reaction of Aryl Chlorides and Dimethylamine.” Tetrahedron Lett. 2009, 50, 3672-3674 [50th anniversary special issue]. 

    10. Fors, Brett P.; Watson, Donald A.; Biscoe, Mark R.; Buchwald, Stephen L. “A Highly Active Catalyst for Pd-Catalyzed Amination Reactions: Cross-Coupling Reactions Using Aryl Mesylates and the Highly Selective Monoarylation of Primary Amines.” J. Am. Chem. Soc. 2008, 130, 13552-13554. 

    9. Biscoe, Mark R.; Fors, Brett P.; Buchwald, Stephen L. “A New Class of Easily Activated Palladium Precatalysts for Facile C–N Cross-Coupling Reactions and the Low Temperature Oxidative Addition of Aryl Chlorides.” J. Am. Chem. Soc. 2008, 130, 6686-6687. [Featured as Editor’s Choice in: Science 2008, 320, 850-851] 

    8. Biscoe, Mark R.; Barder, Timothy E.; Buchwald, Stephen L. “Electronic Effects on the Selectivity of Pd-Catalyzed C–N Bond-Forming Reactions Using Biarylphosphine Ligands: The Competitve Roles of Amine Binding and Acidity.” Angew. Chem. Int. Ed. 2007, 46, 7232-7235. 

    7. Ikawa, Takashi; Barder, Timothy E.; Biscoe, Mark R.; Buchwald, Stephen L. “Pd-Catalyzed Amidations of Aryl Chlorides Using Monodentate Biaryl Phosphine Ligands: A Kinetic, Computational, and Synthetic Investigation.” J. Am. Chem. Soc. 2007, 129, 13001-13007. 

    6. Barder, Timothy E.; Biscoe, Mark R.; Buchwald, Stephen L. “Structural Insights into Active Catalyst Structures and Oxidative Addition to (Biaryl)phosphine-Palladium Complexes via Density Functional Theory and Experimental Studies.” Organometallics 2007, 26, 2183-2192. 

    5. Uyeda, Christopher; Biscoe, Mark; Leplae, Paul; Breslow, Ronald. “Hydrophobically-Directed Selective Reduction of Ketones Using Amine Boranes.” Tetrahedron Lett. 2006, 47, 127-130. 

    4. Biscoe, Mark R.; Breslow, Ronald. “Oxaziridinium Salts as Hydrophobic Epoxidation Reagents: Remarkable Hydrophobically-Directed Selectivity in Olefin Epoxidation.” J. Am. Chem. Soc. 2005, 127, 10812-10813. 

    3. Biscoe, Mark R.; Uyeda, Christopher; Breslow, Ronald. “Requirements for Selective Hydrophobic Acceleration in the Reduction of Ketones.” Org. Lett. 2004, 6, 4331-4334.   

    2. Biscoe, Mark R.; Breslow, Ronald. “Hydrophobically-Directed Selective Reduction of Ketones.” J. Am. Chem. Soc. 2003, 125, 12718-12719.   

    1. Biscoe, M. R.; Fry, A. J. “Dual Reaction Pathways in the Magnesium-Mediated Synthesis of Aziridines from Benzal Halides and Imines.” Tetrahedron Lett. 2001, 42, 2759-2762.

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