Marom Bikson

Post-Doc, Neurophysiology Unit, University of Birmingham Medical School, U.K., 2003 Ph.D., Biomedical Engineering, Case Western Reserve University Cleveland, OH, 2000 B.S., Biomedical Engineering (EE Concentration), Johns Hopkins University, Baltimore, MD, 1995 

Undergraduate Biomedical Engineering Senior Design 1 (BME 405) 

Experimental Methods in Biomedical Engineering (BME 310) 

Biomedical Transducers and Instrumentaiton (BME 405) 

Introduction to Biomedical Enginering (BME 101)

Graduate Neural Engineering

Prof. Marom Bikson’s research group studies the effects of electricity on the human body and applies this knowledge toward the development of medical devices and electrical safety guidelines.

1) Medical devices including biosensors, drug delivery technology, and electrotherapy devices for neurological disorders.

2) Medical device safety including electrical hazards, electroporation, heating damage, and safe stimulation protocols.

3) Electrical safety, electric shock hazards, and accidental electrocution.

4) Understanding the neuronal networks underlying normal brain function, including the role of endogenous electric fields.

5) Developing new treatments for neurological diseases including epilepsy and depression, through translational research. 

Prof. Bikson’s group uses a range of research and engineering design tools including cellular and animal studies, computer simulations, imaging, and clinical evaluation. Prof. Bikson’s research has recieved support from funding agencies including NIH (NINDS,NCI,NIGMS), The Andy Grove Foundation, The Wallace H. Coulter Foundation, and the Howard Hughes Medical Institute. Prof. Bikson is the founder and CEO of Soterix . Prof. Bikson is actively involved in biomedical education including outreach to underserved groups.

Prof. Bikson has provided technical support and consulting for biomedical companies (Medtronic, Boston Scientific, Nevrocorp, Ion Channel Innovations, Wyle), utility companies (Con Edison, First Energy), regulatory agencies (NASA, NY State Public Service Commission, Potomac Institute for Policy Studies), and litigation support.

View Prof. Bikson's CV PDF

Datta A, Rahman A, Scaturro J, Bikson M. Electrode montages for tDCS and weak transcranial electrical stimulation Role of "return" electrode's position and size. Clinical Neurophysiology. 2010; in press

Minhas P, Patel J, Bansal V, , Ho J, Datta A, Bikson M. Electrodes for high-definition transcutaneous DC stimulation for applications in drug-delivery and electrotherapy, including tDCS. Journal of Neuroscience Methods . 2010; in press

Datta A, Bikson M, Fregni F. Transcranial direct current stimulation in patients with skull defects and skull plates: High-resolution computational FEM study of factors altering cortical current flow. Neuroimage. 2010; in press

Sunderam S, Gluckman B, Reato D, Bikson M. Toward rational design of electrical stimulation strategies for epilepsy control. Epilepsy & Behavior. 2010; 17:6-22 PDF

Lopez-Quitero SV, Datta A, Amaya R, Elwassif M, Bikson M, Tarbell JM. DBS-relevant electric fields increase hydraulic conductivity of in vitro endothelial monolayers. Journal of Neural Engineering. 2010; 7(1) PDF

Radman T, Ramos RL, Brumberg JC, Bikson M. Role of cortical cell type and morphology in sub- and suprathreshold uniform electric field stimulation. Brain Stimulation. 2009; 2(4):215-228. PDF

Datta A, Bansal V, Diaz J, Patel J, Reato D, Bikson M. Gyri –precise head model of transcranial DC stimulation: Improved spatial focality using a ring electrode versus conventional rectangular pad. Brain Stimulation. 2009; 2(4):201-207. PDF

Bikson M, Datta A, Elwassif M. Establishing safety limits for transcranial direct current stimulation. Clinical Neurophysiology. 2009; 120:1033-1034. PDF

Bikson M, Bulow P, Stiller JW, Datta A, Battaglia F, Karnup SV, Postolache TT. Transcranial direct current stimulation for major depression: a general system for quantifying transcranial electrotherapy dosage. Current Treatment Options in Neurology. 2008; 10:377-85. PDF

Datta A, Elwassif M, Battaglia F, Bikson M. Transcranial current stimulation focality using disc and ring electrode configurations: FEM analysis. Journal of Neural Engineering. 2008; 5:163-174. PDF 

An JH, Radman T, Su Y, Bikson M. Effects of glucose and glutamine concentration in the formulation of the artificial cerebrospinal fluid (ACSF). Brain Research. 2008; 1218:1586-93 PDF 

Su Y, Radman T, Vaynshteyn J, Parra LC, Bikson M. Effects of high-frequency stimulation on epileptiform activity in vitro: ON/OFF control paradigm. Epilepsia. 2008; 49:1586-93 PDF 

Radman T, Su Y, An JH, Parra L, Bikson M. Spike timing amplifies the effect of electric fields on neurons: Implications for endogenous field effects Journal of Neuroscience. 2007; 27:3030-3036. PDF

Fox JE, Bikson M, Jefferys JG. The effect of neuronal population size on the development of epileptiform discharges in the low calcium model of epilepsy. Neuroscience Letters. 2007; 411:158-61. 

Elwassif MM, Kong Q, Vazquez M, Bikson M. Bio-heat transfer model of deep brain stimulation-induced temperature changes. Journal of Neural Engineering. 2006; 3:306-15. PDF

Merrill D, Bikson M, Jefferys JGR. Electrical stimulation of excitable tissue: design of efficacious and safe protocols. Journal of Neuroscience Methods. 2005; 141: 171-198 PDF

Fox JE, Bikson M, Jefferys JGR. Tissue resistance changes and the profile of synchronized neuronal activity during ictal events in the low calcium model of epilepsy. Journal of Neurophysiology. 2004; 92: 181-188 PDF

Bikson M, Inoue M, Akiyama H, Deans JK, Fox JE, Miyakawa H, Jefferys JGR. Effects of uniform extracellular DC electric fields on excitability in rat hippocampal slices in vitro.  Journal of Physiology. 2004; 557: 175-190 PDF

Bikson M, Hahn PJ, Fox JE, Jefferys JGR. Depolarization block of neurons during maintenance of electrographic seizures. Journal of Neurophysiology. 2003; 90: 2402-2408 PDF

Jefferys JGR, Deans J, Bikson M, Fox J. Effects of weak electric fields on the activity of neurons and neuronal network. Radiation Protection Dosimetry. 2003; 106:321-323

Shuai J, Bikson M, Lian J, Hahn PJ, Durand DM. Ionic mechanisms underlying spontaneous CA1 neuronal firing in Ca2+-Free Solution. Biophysical Journal 2003; 84: 2099-111

Lian J, Bikson M, Sciortino C, Stacey WC, Durand DM. Local suppression of epileptiform activity by AC Fields. Journal of Physiology. 2003; 547: 427-434

Bikson M, Fox JE, Jefferys JGR. Neuronal aggregate formation underlies spatio-temporal dynamics of non-synaptic seizure initiation. Journal of Neurophysiology. 2003; 89: 2330-2331 PDF

Bikson M, Id Bihi R, Vreugdenhil M, Kohling R, Fox JE, Jefferys JGR. Quinine suppresses extracellular potassium transients and ictal epileptiform activity without decreasing neuronal excitability in vitro. Neuroscience 2002; 115: 253-263

Lian J, Bikson M, Shuai J, Durand DM. Propagation of non-synaptic epileptiform activity across lesion in rat hippocampal slices. Journal of Physiology 2001; 537; 191-199

Bikson M, Baraban SC, Durand DM. Conditions sufficient for non-synaptic epileptogenesis in the CA1 region of rat hippocampal slices. Journal of Neurophysiology 2001; 87:62-71 PDF

Bikson M, Lian J, Hahn PJ, Stacey WC, Sciortino C, Durand DM. Suppression of epileptiform activity by high frequency sinusoidal fields in rat hippocampal slices. Journal of Physiology 2001; 531:181-191 PDF

Durand DM, Bikson M. Suppression and control of epileptiform activity by electrical stimulation: a review. Proceedings of the IEEE 2001; 89:1065-1082 PDF

Ghai R, Bikson M, Durand DM. Effects of applied electric fields on low calcium epileptiform activity in the CA1 region of rat hippocampal slices. Journal of Neurophysiology 2000; 84:274-280 PDF

Bikson M, Ghai R, Baraban SC, Durand DM. Modulation of burst frequency, duration, and amplitude in the zero-Ca+2 model of epileptiform activity. Journal of Neurophysiology 1999; 82:2262-70 PDF