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Faculty and Staff Profiles

Eitan Friedman

Medical Professor
Chair

School/Division

Sophie Davis School of Biomedical Education

Department

Office

Harris Hall 203

p: 212-650-6994

f: 212-650-6696

e: friedman@med.cuny.edu

  • Education

    B.A.,1966, Brooklyn College

    Ph.D., 1971, New York Medical College

  • Research Interests

    • Transmembrane signaling via G protein-coupled receptors and plasticity of these receptors in health and disease.

    • Role of MAP kinases in GPCR signaling.

    • Role of altered cellular signal transduction in the etiology of bipolar illness and in the mechanism of action of mood stabilizers.

    • Characterization of a novel brain dopamine receptor that couples to phospholipase C.

    • Molecular mechanisms involved in mediating the morphological and behavioral effects of in utero exposure to cocaine.






  • Publications

    ARTICLES

    • L.-C. Shi, H.-Y. Wang, and E. Friedman: Involvement of platelet-activating factor in cell death induced under ischemia/postischemia-like conditions in an immortalized hippocampal cell line, J. Neurochem, 70:1035-1044, 1998.

    • H. Gurdal, M.D. Johnson, E. Friedman and H.O. Onaran: Decrease in apparent a1-adrenoceptor-G protein coupling during maturation in rat aorta. J. Gerontol., 1998.

    • D.L. Snyder, W. Wang, A. Pelleg, E. Friedman, J. Horwitz and J. Roberts: The effect of aging on A1-adenosine receptor mediated inhibition of norepinephrine release in the rat heart. Cardiovas. Pharm., 31:352-358, 1998.

    • E. Gao, D.L. Snyder, E. Friedman, G. Cai, J. Roberts, and J. Horwitz: Age-related decline in adenosine A1 receptor function in hearts of ad libitum and dietary restricted rats. J. Pharmacol. Exp. Therap. 285:186-192, 1998.

    • X. Zhen, K. Uryu, H.-Y. Wang and E. Friedman: D1-dopamine receptor agonists mediate activation of p38 MAPK and JNK by a PKA-dependent mechanism in SK-N-MC human neuroblastoma cells. Mol. Pharmacol. 54:453-458, 1998.

    • S. Bhamre, H.Y. Wang and E. Friedman: Receptor mediated palmitoylation and depalmitoylation of G protein a subunits in rat cortical membranes. J. Pharmacol. Exp. Therap. 286:1482-1489, 1998.

    • L.-Q. Jin, G. Cai, H.-Y. Wang, C. Smith and E. Friedman: Characterization of the phosphoinositide-linked dopamine receptor in a mouse hippocampal-neuroblastoma hybrid cell line. J. Neurochem. 71:1935-1943, 1998.

    • H.Y. Wang and E. Friedman: Effects of lithium on receptor-mediated activation of G proteins in rat brain cortical membranes. Neuropharmacol.38:403-414, 1999.

    • H.Y. Wang, P. Markowitz, D. Levinson, A.S. Undie and E. Friedman: Increased membrane-associated protein kinase C activity and translocation in blood platelets from bipolar affective disorder patients. J. Psych. Res.33: 171-179,1999.

    • A. Schmidt, M.K. Holloway, R. Vogel, S.J. Rutledge, O. Friedman, Z. Yang, L.C.Shi, G.A. Rodan and E. Friedman: Transcription control and neuronal differentiation by agents that activate LXR nuclear receptor family. Mol. Cell. Endocrinol. 155:51-60, 1999.

    • G. Cai, H. Gurdal, C. Smith, H-Y. Wang, and E. Friedman: Inverse agonist properties of dopaminergic antagonists at the D1A dopamine receptor: uncoupling of the D1A dopamine receptor from Gs protein. Mol. Pharmacol. 56:989-996, 1999.

    • C.G. Hahn and E. Friedman: Abnormalities in protein kinase C signaling and the pathophysiology of bipolar disorder. Bipolar Disorders 1:81-86,1999.

    • X. Zhen, K. Uryu, G. Cai and E. Friedman: Age-associated impairment in brain ERK signal pathway in Fisher 344 rats. J. Gerontol.54A: B539-B548, 1999.

    • J. Xu, E. Gao, X Ma, F. Gao, E. Friedman, D.L. Snyder, J. Horwitz and A. Pelleg: Effects of aging on the negative chronotropic and anti- adrenergic actions of adenosine in the rat heart. Cardiovas. Pharmacol. 34:904-912, 1999.

    • G. Cai, X. Zhen, K. Uryu, and E. Friedman: Activation of extracellular signal-regulated protein kinases is associated with a sensitized locomotor response to D2 dopamine receptor stimulation in unilateral 6-hydroxydopamine-lesioned rats. J Neurosci. 20:1849-1857, 2000.

    • H.Y. Wang, T.R. Bashore, and E. Friedman: Age-related decreases in lymphocyte protein kinase C and translocation are reduced by aerobic fitness. J Gerontol. 55A, B545-B551, 2000.

    • F. Gao, T. A. Christopher, B.L. Lopez, X. L. Ma, G. Cai, and E. Friedman: Mechanism of decreased adenosine protection in reperfusion injury of aging rats. Am. J Physiol. 279:H329-H338.

    • A. Can, K. Sayar, E. Friedman, C. Ambrosio, E. Erdemli, and H. Gurdal: The effect of agonist stimulation and b2-adrenergic receptor level on cellular distribution of Gsa protein. Cell. Signal. 12:303-309, 2000.

    • L. B. Jones, D. Stanwood, B. S. Reinoso, R. A. Washington, H.Y. Wang, E. Friedman, and P. Levitt: In utero cocaine-induced dysfunction of dopamine D1 receptor signaling and abnormal differentiation of cerebral cortical neurons. J Neursci. 20:4606-4614, 2000.

    • N.Tilakaratne, G. Cai, and E. Friedman: Attenuation of cocaine-induced genomic and functional responses in prenatal cocaine-exposed rabbits. Pharmcol. Biochem.& Behavior 69:225-232, 2001.

    • A. Harvey, A. G. Romano, M. Gabriel, K. J. Simansky, W. Du, V.J.Aloyo, and E. Friedman: Effects of prenatal exposure to cocaine on the developing brain: anatomical, chemical, physiological and behavioral consequences. Neurotoxicol. Res. 3:117-143, 2001.

    • X. Zhen, W. Du, A. G. Romano, E. Friedman, and J.A. Harvey: The p38 Mitogen-activated protein kinase is involved in associative learning in rabbits J. Neurosci. 21:5513-5519, 2001.

    • T.M . Seasholtz, G. Cai, H.Y. Wang, and E. Friedman: Effects of ischemia-reperfusion on vascular contractility and α1 adrenergic receptor signaling in the rat tail. J. Appl. Physiol. 91:1004-1010, 2001.

    • L.Q. Jin, H.Y. Wang and E. Friedman : Stimulated D1 dopamine receptors couple to multiple Gα proteins in different brain regions. J. Neurochem. 78, 1-11, 2001.

    • H.Y. Wang, G. P. Johnson, E. Friedman: Chronic lithium treatment inhibits protein kinase C translocation in rat brain cortex. Psychoparmacol. 158, 80-86, 2001.

    • X. Zhen, J. Zhang, G.P. Johnson, E. Friedman: D4 dopamine receptor differentially regulates Akt/NF-κB and ERK pathway in D4MN9D cells. Mol. Pharmacol 60, 857-864,2001.

    • X. Zhen, C. Torres, H.Y. Wang, E. Friedman. Prenatal exposure to cocaine disrupts D1A dopamine receptor function via selective inhibition of protein phosphatase 1 pathway in rabbit frontal cortex. J Neurosci. 21, 9160-9167, 2001.

    • H.Y. Wang and E. Friedman: Increased association of brain protein kinase C with RACK1 in bipolar affective disorder: implication for enhanced protein kinase C activation. Biol. Psych. 50:364-370, 2001.

    • G. Cai, H. Y. Wang, and E. Friedman: Increased dopamine receptor signaling and dopamine receptor-G protein coupling in denervated striatum. J. Pharmacol. Exper. Ther.302:1105-1112, 2002.

    • X. Zhen, C. Torres, and E. Friedman: Lithium regulates protein tyrosine phosphatase in vitro and in vivo. Psycopharmacol.2002.

    • L.Q. Zhen, S. Goswami, G. Cai, X. Zhen and E. Friedman: SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain. J. Neurochem. 85, 378-386, 2003.

    • M. Gil, X. Zhen and E. Friedman. Prenatal cocaine exposure alters glycogen synthase kinase-3ß (GSK3ß) pathway in select rabbit brain areas. Neurosci. Letters. 349:143-146, 2003.

    • H.Y. Wang and E. Friedman: Aberrant serotonin receptor-mediated activation of G proteins in postmortem brains from Alzheimer's disease patients. Mid Taiwan J. Med. 9, 1-10, 2004.

    • X.Zhen, S.Goswami, S.A. Abdali, M. Gil, K. Bakshi and E. Friedman: Regulation of Cyclin-Dependent Kinase 5 and Calcium/Calmodulin-Dependent Protein Kinase II by Phosphatidylinositol-Linked Dopamine Receptor in Rat Brain. Mol. Pharm. 66:1500-1507, 2004.

    • C.G. Hahn, Umapathy, H.Y. Wang, R. Koneru, D.F. Levinson and E. Friedman: Lithium and valproic acid treatments reduce PKC activation and receptor-G protein coupling in platelets of bipolar manic patients. J. Psychiatric. Res. 39:355-363, 2005.

    • C.G. Hahn, G. Gomez, N. Rawson, D. Restrepo, E. Friedman, R. Josiason, E.A. Pribitkin, L.D. Lowry, R.J. Gallop and N.E. Rawson: Aberrant intracellular calcium signaling in olfactory neurons from bipolar patients. Am. J. Psy. 162:616-618, 2005.

    • A. Schmidt, Azriel, Vogel, R., Rutledge, S.J., Opas, E.E., Rodan, G.A., and Friedman, E. Cross talk between an activator of nuclear receptors-mediated transcription and the D1 dopamine receptor signaling pathway. Pharmacol Biochem. Beh. 80:379-385, 2005.

    • X. Zhen, S. Goswami, S. A. Amir, M. Gil, and E. Friedman:The role of the phosphatidylinositol linked D1 dopamine receptor in the pharmacology of SKF83959. Pharmacol. Biochem. Beh. 80:597-601, 2005.

    • H.Y. Wang, E. Friedman, M.C. Olmstead, and L.H. Burns: Ultra-low-dose naloxone suppresses opioid tolerance, dependence and associated changes in MU opioid receptor-g protein coupling and Gβγ signaling. Neuroscience 135:247-261, 2005.

    • F. Battaglia, H.Y. Wang, M. Felice Ghilardi, E. Gashi, A. Quartarone, E. Friedman and R. A. Nixon: Cortical Plasticity in Alzheimer's Disease in Humans and Rodents. Biol. Psych. 62:1405-1412, 2007.

    • M. Frankfurt, H.Y. Wang, N. Marmolejo, K. Bakshi, E. Friedman: Prenatal cocaine increases dendritic spine density in the medical prefrontal cortex, hippocampus and striatum of the rat. Developmental Neurosci, 2008 (in press)

    • T. Inagaki, M. Frankfurt, E. Friedman, V. Luine: Bisphenol Alters estrogen-induced memory enhancement: alterations in spine density and monoamines in rat brain, (in press)

    • X. Zhen, P. Sun, J. Wang, W. Gu, W. Cheng, G. Jin, E. Friedman and J.Zheng: PSD-95 Regulates D1 Dopamine Receptor Resensitization but not Receptor-mediated Gs-protein Activation. Cell Research (in press)

    • K. Bakshi, S. Gennaro, C.Y. Chan, M. Kosciuk, J. Liu, A. Stucky, E. Trenkner, E. Friedman, R.G. Nagele, H.Y. Wang: Prenatal cocaine reduces AMPA receptor synaptic expression through hyperphosphorylation of the synaptic anchoring protein GRIP. J. Neurosci. (in press)

    • R. Crupi, M. Cambiaghi, L. Spatz, R. Hen, M. Thorn, E. Friedman, G. Vita, F. Battaglia: Reduced adult neurogenesis and altered emotional behaviors in autoimmune-prone BAFF transgenic mice, Biol. Psych (in press)

    BOOKS AND BOOK CHAPTERS

    • G. Cai, H.Y. Wang and E. Friedman: The role of adenosine in the regulation of cardiac function: The effect of aging. In: Effects of Extracellular Adenosine and ATP on Cardiomyocytes. Ed: A. Pelleg and L. Belardinelli, R.G. Landes Co., Austin, TX, 1998.

    • E. Friedman and H.Y. Wang: Prenatal cocaine exposure alters signal transduction in the brain D1 dopamine receptor system. In: Cocaine: Effects on the Developing Brain. Ann. N.Y. Acad. Science, Vol, 846. Ed: J.A. Harvey and B.E. Kosofsky, pp 238-247, 1998.

    • N. Tilakaratne, G. Cai and E. Friedman: Cocaine-induced activation of c-fos gene expression is attentuated in prenatal cocaine-exposed rabbits. In: Cocaine: Effects on the Developing Brain. Ann. N.Y. Acad. Science, Vol, 846. Ed: J.A. Harvey and B.E. Kosofsky, pp 368-370, 1998.

    • H.Y. Wang, D.L. Snyder and E. Friedman: Changes in neurotransmitter exocytosis: a target for regulation during aging. In: Methods in Aging Research. Ed: B.P.Yu, CRC Press, Boca Raton, FL, 1998.

    • A. Harvey, A. G. Romano, M. Gabriel, K. J. Simansky, W. Du, V.J. Aloyo, E. Friedman: Effects of prenatal exposure to cocaine on the developing brain: anatomical, chemical, physiological and behavioral consequences. In: Strategies for Studying Brain Disorders 5: Neurodegenerative Brain Disorders. Ed: Tomas Palomo, Richard J Beninger and Trevor Archer, Fundacion Cerebro y Mente, Madrid, Spain. Chapter 4,  pp.61-96, 2000

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