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Faculty and Staff Profiles

Patricia Ann Broderick

Medical Professor

School/Division

Sophie Davis School of Biomedical Education

Department

Office

Harris Hall 310

p: 212-650-5479

f: 212-650-7726

e: Broderick@med.cuny.edu

  • Education

    Ph.D., 1979, St. John's University

    M.S., 1970, Fordham University

    B.S., 1963, St. Thomas Aquinas College

    Postdoctoral Positions
    Dept. of Psychiatry & Neuroscience, Albert Einstein College of Medicine, NY
    Dept. of Neurology, Cornell University School of Medicine, NY

  • Research Interests

    Development of miniature biosensors for the detection of neurotransmitters and other biologically active compounds such as ascorbic acid, peptides, precursors and metabolites. These BRODERICK PROBE® biosensors allow the study of dynamic changes in neurotransmitters in vivo and in real time, on line with behavioral models as well as on line Neuromolecular Imaging (NMI) with biosensors with cerebral blood flow studies of stroke in animal models.

    Studies of cocaine, caffeine, hypoxia, calcium channel blockers, hypotension and nitroglycerin are underway. Ongoing significant advances have been made with these biosensors in human studies in epilepsy patients beginning in 2008 during intraoperative diagnosis of temporal lobe epilepsy with Internal Review Board Approval, NYU, Tisch Hospital , NY.

    Pharmacotherapeutic approaches to the treatment of cocaine abuse, caffeine mechanisms, pain, affective disorders, epilepsy, tumors, schizophrenia, Parkinson's disease, post-operative cognitive diseases, drug addiction, oxidative stress, inflammation, cytokines,  hypertension, hypoxia, calcium channel blockers, nitroglycerin, ascorbic acid, peptides, stress, enkephalins, dynorphin, morphine, diabetes, Fawn-Hooded animal models, Chediak-Higashi Syndrome.

  • Publications

    Peer-Reviewed Articles

    Broderick, P.A., Doyle, W.K., Pacia, S.V., Kuzniecky, R.I., Devinsky, O, and Kolodny, E.H., A clinical trial of an advanced diagnostic biomedical device for epilepsy patients. Journal of Long-Term Effects of Medical Implants, In Press, (2009).

    Broderick, P.A., Ho, H., Wat, K. and Murthy, V., Laurate biosensors image brain neurotransmitters in vivo: Can an antihypertensive medication alter psychostimulant behavior? Sensors 8: 4033-4061 (2008).

    Broderick, P.A., Studies of oxidative stress mechanisms using a morphine/ascorbate animal model and novel N-stearoyl cerebroside and laurate sensors. J. Neural Transm. 115: 7-17 (2008).

    Nunes, J.V. and Broderick, P.A., Novel research translates to clinical cases of schizophrenic and cocaine psychosis. Neuropsychiatric Disease and Treatment 3(4): 475-485 (2007).   

    Broderick, P.A.; Pacia, S.V. Identification, diagnosis, and treatment of neuropathologies, neurotoxicities, tumors and brain and spinal cord injuries using microelectrodes with microvoltammetry. 2006, U.S. Patent # 7,112,319. Issued, Sept. 26th (2006).

    Broderick, P.A.  and Hope, O., Monoamines and motor responses are co-deficient in the Fawn-Hooded depressed animal model.  Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 30: 887-898 (2006).

    Simmons, D.A. and Broderick, P.A.. Cytokines, stressors and clinical depression: augmented adaptation responses underlie depression pathogenesis. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 29: 793-807 (2005).

    Broderick, P.A., Olabisi, O.A., Rahni, D.N. and Zhou, Y., Cocaine acts on accumbens monoamines and locomotor behavior via a 5-HT2A/2C receptor mechanism as shown by ketanserin: 24 hr follow-up studies. Prog. Neuro-Psychopharmacol. & Biol. Psychiat.  28: 547-557 (2004).

    Broderick, P.A., Hope, O., Okonji, C., Rahni, D.N. and Zhou, Y., Clozapine and cocaine effects on dopamine and serotonin release in nucleus accumbens during psychostimulant behavior and withdrawal. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 28: 157-171 (2004).

    Broderick, P.A., Rahni, D.N. and Zhou, Y., Acute and subacute effects of risperidone and cocaine on accumbens dopamine and serotonin release using in vivo microvoltammetry on line with open-field behavior. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 27: 1037-1054 (2003).

    Broderick, P. A. Interieukin 1a alters hippocampal serotonin (5-HT) and norepinephrine (NE) release during open-field behavior in Sprague Dawley animals: Differences from the Fawn-Hooded animal model of depression. Prog. Neuro-Psychopharmacol. & Biol. Psychiat.  26: 1355-1372 (2002).

    Pacia, S. V., Doyle, W. K. and Broderick, P. A., Biogenic amines in resected human neocortex in patients with neocortical and mesial temporal lobe epilepsy; Identification with in situ microvoltammetry. Brain Research 899:106-111 (2001)

    Broderick, P. A., Pacia, S. V., Doyle, W. K. and Devinsky, O., Monoamine neurotransmitters in resected hippocampal subparcellations from neocortical and mesial temporal lobe epilepsy patients: In situ microvoltammetric studies. Brain Research 878:48-63 (2000)

    Broderick,P.A., Microelectrodes and their use in a cathodic electrochemical current arrangement with telemetric application. Canadian Patent and PCT # 2,063,607. Issued Nov. 24th(2000).

    Broderick, P.A., Microelectrodes and their use in a cathodic electrochemical current arrangement with telemetric application. U.S. Patent # 5,938,903. Issued, Aug. 17th (1999). Broderick, P.A., Microelectrodes and their use in a cathodic electrochemical current arrangement with telemetric application. Hong Kong, The People's Republic of China, Patent # HK 1007350. Issued, Aug. 9th (1999).

    Broderick, P. A. and Piercey, M. F., Neurochemical and behavioral evidence supporting (+)-AJ 76 as a potential pharmacotherapy for cocaine abuse. J. Neural Transm. 105: 1307-1324 (1998).

    Broderick, P. A. and Piercey, M. F., Clozapine, haloperidol and the D4 antagonist PNU-101387G: In vivo effects on mesocortical, mesolimbic and nigrostriatal dopamine and serotonin release. J. Neural Transm. 105:749-767 (1998).

    Broderick, P. A., Hope, O. and Jeannot, P. Mechanism of triazolo-benzodiazepine and benzodiazepine action in anxiety and depression: behavioral studies with concomitant in viro CA1 hippocampal norepinephrine and serotonin release detection in the behaving animal. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 22:353-386 (1998).

    Book Chapters

    Simmons, D.A. and Broderick, P.A.. Cytokines, stressors and clinical depression: augmented adaptation responses underlie depression pathogenesis. In: Selective Affective Disorders and Schizophrenia.Prog. Neuro-Psychopharmacol. & Biol. Psychiat.(Eds. Broderick, P.A. and Glazer, W.M.) 29: 793-807 (2005).

    Pacia, S.V. and Broderick, P.A., Bioimaging L-Tryptophan   in human hippocampus and neocortex subtyping temporal lobe epilepsy with microvoltammetry.In: Bioimaging in Neurodegeneration(Eds. Broderick, P.A., Rahni, D.N. and Kolodny, E.H.) Humana Press Inc., Totowa, NJ, pp. 141-147 (2005).

    Broderick, P.A., Rahni, D.N. and Pacia, S.V., Nano-and microimaging surgical anesthesia in epilepsy patients. In: Bioimaging in Neurodegeneration (Eds. Broderick, P.A., Rahni, D.N. and Kolodny, E.H.) Humana Press Inc.., pp. xiii-Totowa, NJ, pp. xiii-xvi (2005).

    Broderick, P.A.  and   Pacia, S. V., Imaging white matter signals in epilepsy patients: A unique sensor technology. In: Bioimaging in Neurodegeneration  (Eds. Broderick, P.A., Rahni, D.N. and Kolodny, E.H.) Humana Press Inc., Totowa, NJ, pp.199-206 (2005).

    Broderick, P.A., Microsensors detect cocaine neuroadaptation: Serotonin release within basal ganglia is not rhythmic with movement. In: Handbook of Neurotoxicology (Eds. Massaro, E.J., Schardein, J.L., Broderick, P.A., Schlaepfer, T.E. and Mattsson, J.L.)  Humana Press Inc., Totowa, NJ, 2: pp.323-367 (2002).

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