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Faculty and Staff Profiles

Robert Alfano

Distinguished Professor
Fellow, American Physical Society; Fellow, Optical Society of America; Fellow, IEEE

School/Division

Division of Science

Department

Physics

Affiliated Departments

Electrical Engineering
Institute for Ultrafast Spectroscopy and Lasers

Office

Marshak 201

p: 212-650-5531

f: 212-650-6940

e: ralfano@sci.ccny.cuny.edu

w: View my website >>

  • Profile

    City College of NY, 4/1987-present, Distinguished Professor of Physics and Electrical Engineering, Science and Engineering    
    The Graduate School & Univ. Ctr    7/2001-present,    Distinguished Professor    Psychology
    City College of NY, 1983-87, Herbert Kayser Professor, Electrical Engineering
    City College of NY, 1978-87, Professor    Physics
    City College of NY, 1974-77, Assoc. Prof., Physics
    City College of NY, 1972-74, Asst. Prof., Physics
    Fairleigh Dickinson Univ., 1968-72, Adjunct Lect., Physics

    Robert Alfano is a Distinguished Professor of Science and Engineering at the City College of CUNY, where he has been a faculty member in the Department of Physics since 1972. Prior to joining the City College, Dr. Alfano was a Research Physicist at GTE Research Laboratories, 1964-1972. He received his Ph.D. in Physics from New York University in 1972, and his Bachelor's and Master's in Physics from Fairleigh Dickinson University in 1963 and 1964, respectively. He is a Fellow of American Physical Society, Optical Society of America, and IEEE. He is director of CCNY's Institute of Ultrafast Spectroscopy and Lasers.



    Robert Alfano has been involved in developing ultrafast laser spectroscopic techniques and applications of these techniques to study ultrafast dynamical processes in physical, chemical, and biological systems. His research encompasses the study and development of supercontinuum, tunable solid-state lasers, nonlinear optical processes, application of optical spectroscopic techniques for medical diagnosis (optical biopsy), study of photon migration in turbid media, and development of optical imaging techniques for biomedical imaging (optical mammography). He has published more than 700 papers and holds 102 patents. He has mentored 50 Ph.D. students.

  • Education


    B.S., M.S,  Fairleigh Dickinson Univ.; Ph.D., New York Univ.
  • Research Interests

    Ultrafast laser physics
    Biomedical optics
    Nonlinear optics
    Optical imaging

  • Publications

    Google Scholar

    Yimin Wang, S. K. Gayen, M. Alrubaiee, and R. R. Alfano Near-infrared center-of-intensity time gated imaging for detection of a target in a highly scattering turbid medium, Technology in Cancer Research and Treatment, Volume# 11, Pages; 309 - 315 (2012).



    R. R. Alfano, X. Chen, J. Koh, M.-J. Li, D. Aloysius, H. Sztul, Cylindrical Polarization Beams, US Patent Office, US Patent #8,111,957 B2 (2012).

    Y. Pu, W. B. Wang, S. Achilefu, and R. R. Alfano Study of rotational dynamics of receptor-targeted contrast agents in cancerous and normal prostate tissues using time-resolved picosecond emission spectroscopy, Applied Optics, 50(10), 1312-1322. (2011).

    Y. Pu, G. C. Tang, W. B. Wang, H. E. Savage, S. P. Shantz, and R. R. Alfano Native fluorescence spectroscopic evaluation of chemotherapeutic effects of malignant cells using nonnegative matrix factorization analysis, Technology in Cancer Research and Treatment, 10(2), 113-120 (2011).

    J. Ebenezar, Y. Pu, C. H. Liu, W. B. Wang, and R. R. Alfano Diagnostic potential of Stokes shift spectroscopy of breast and prostate tissues - a preliminary pilot study, Technology in Cancer Research and Treatment, 10(2), April 2011, 153-161. (2011).

    Pavel Shumyatsky and Robert R. Alfano Terahertz sources, Journal of Biomedical Optics, 16(3), March 2011, 0330011-0330019 (2011).

    Michelet Jeanty, V. Kartazaev, M. Sharonov, A. Bykov, and R. R. Alfano Ultrafast laser pulses generated from the chromium-doped cunyite crystal, Optics Communications, 284, 1339-1341 (2011).

    R. R. Alfano, A. Alimova, A. Katz Phosphorescence and Fluorescence Spectroscopy for Detection of Cancer and Pre-Cancer from Normal/Benign Regions, US Patent #7,986,989 B2, US Patent Office (2011).

    R. R. Alfano, A. Katz, S. Alfano Micro-Scale Compact Device for In Vivo Medical Diagnosis Combining Optical Imaging and Point Fluorescence Spectroscopy, US Patent Office, US Patent #8,082,024 B2 (2011).

    S. K. Zhang, Thander Myint, W. B. Wang, B. B. Das, Noemi Perez-Paz, H. Lu, M. C. Tamargo, A. Shen, R. R. Alfano Optical study of strongly coupled CdSe quantum dots, J. Vac. Sci. Technol., B 28, C3D17 (2010).

    Y. Pu, G. Tang, W. B. Wang, R. R. Alfano Changes of collagen and nicotinamide adenine dinucleotide in human cancerous and normal prostate tissues studied using native fluorescence spectroscopy with selective excitation wavelength, Journal of Biomedical Optics, 18(4), 0470081-0470085 (2010).

    Shengkun Zhang, Wubao Wang, A. Teke, L. He, S. Dogan, D. J. Johnstone, H. Morkoc, and Robert R. Alfano Photoionization study of deep centers in GaN/AlGaN multiple quantum wells, J. Vac. Sci. Technol., B28, C3I10- C3I12 (2010).

    Yang Pu, W. Wang, and R. R. Alfano Time-Resolved Fluorescence Spectroscopy of Contrast Agent, ICG, Influenced by Rotational Motion, Proc. of OSA/FiO/LS, JTuA19 (2010).

    R. R. Alfano, Min Xu, Mohammed Alrubaiee, and S. K. Gayen Optical tomography using independent component analysis for detection and localization of targets in turbid media, U. S. Patent Office, U. S. Patent Number: 7,826,878 B2 (2010).

    G. Milione, H. Sztul, and R. R. Alfano Stokes Polarimetry of a Hybrid Vector Beam from a Spun Elliptical Core Optical Fiber, Complex Light and Optical Forces IV, Proc. of SPIE Vol. 7613, 761305-1-5 (2010).

    R. R. Alfano, V. Kartazaev, I. Zeylikovich, B. Das, and D. Nolan UV Extended Supercontinuum Source for Time Resolved and Steady State Spectroscopy for Biological and Chemical Molecules, Optical Biopsy VIII, Proc. of SPIE Vol. 7561, 756107-1-6 (2010).

    C. H. Liu, W. Wang, V. Kartazaev, H. Savage, and R. R. Alfano Changes of Collagen, Elastin, and Tryptophane Contents in Laser Welded Porcine Aorta Tissues Using Fluorescence Spectroscopy, Optical Biopsy VIII, Proc. of SPIE Vol. 7561, 756115-1-8 (2010).

    A. Alimova, V. Sriramoju, R. Chakraverty, R. Muthukattil, and R. R. Alfano Healing and Evaluating Guinea Pig Skin Incision After Surgical Suture and Laser Tissue Welding by Using Raman Spectroscopy, Optical Biopsy VIII, Proc. of SPIE Vol. 7561, 756114-1-5 (2010).

    Y. Pu, W. B. Wang, S. Achilefu, and R. R. Alfano Rotational dynamics and polarization anisotropy of bound and unbound receptor-targeted contrast agents in cancerous and normal prostate tissues studied by time-resolved fluorescence spectroscopy, Optical Biopsy VIII, Proc. of SPIE Vol. 7561, 75610A-1-8 (2010).

    G. C. Tang, W. B. Wang, Y. Pu, and R. R. Alfano Optical Birefringence of Aorta Tissues, Optical Biopsy VIII, Proc. of SPIE Vol. 7561, 756116-1-9 (2010).

    Yang Pu, WubaoWang, Guichen Tang, Robert R. Alfano Changes of NADH and Collagen Contents as Biomarkers in Cancerous Prostate Tissue Analyzed by Selective Excitation Fluorescence, Biomedical Optics (BIOMED)/ Digital Holography and Three-Dimensional Imaging (DH), BCW6-1-3 (2010).

    Robert Alfano, Ali Jamal, Wubao Wang, Manuel Zevallos Detecting human cancer through spectral optical imaging using key water absorption wavelengths, US Patent, #7,706,862 (2010).

    R. R. Alfano, M. Xu, M. Alrubaiee, S. Gayen Optical Tomography using Independent Component Analysis for Detection and Localization of Targets in Turbid Media, US Patent, #7,826,878 B2 (2010).

    R. R. Alfano, X. Ni Imaging Systems and Methods to Improve Backscattering Imaging Using Circular Polarization Memory, US Patent #7,515,265 B2, US Patent Office (2010).

    A. Alimova, R. Chakraverty, R. Muthukattil, S. Elder, A. Katz, V. Sriramoju, Stanley Lipper, R. R. Alfano In vivo Molecular Evaluation of Guinea Pig Skin Incisions Healing after Surgical Suture and Laser Tissue Welding Using Raman Spectroscopy, JOurnal of Photochemistry and Photobiology, 96(3), 178-183, DOI 10.1016/j.jphotobiol.2009.06.004 (2009).

    Zeylikovich, I., Shumyatsky, P., Gayen, T.K., Alfano, R.R. Ultraviolet-to-visible image conversion microscopy using photoluminescence from self-assembled CdSe/ZnCdMgSe quantum dots, Applied Optics, 48 (2009).

    Pu Y., Wang W.B., Das B.B., Alfano R.R. Time-resolved polarization-dependent native near infrared spectral wing emission of human cancerous and normal prostate tissues, Optical Tomography and Spectroscopy of Tissue VIII, Proc. of SPIE, Vol. 7174, p. 71741W-1, 6 pp. (2009).

    Alfano R.R. Overview on the State of the Art Biomedical Optical Spectroscopy and Imaging for Future Healthcare, Keynote speech, Ocean Optics Global Distributor Retreat, April 26-30, 2009, Orlando, FL (2009).

    Editors: Tromberg B.J., Yodh A.G., Tamura M., Sevick-Muraca E.M., Alfano R.R. Optical Tomography and Spectroscopy of Tissue VIII, Proc. of SPIE, Vol. 7174 (2009).

    Alrubaiee M. , Xu M. , Gayen S. K., and Alfano, R. R. Multi-wavelength optical tomography using independent component analysis, Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Bedside, National Institutes of Health, Bethesda, Maryland, USA. (2009).

    H. Sztul, R. R. Alfano Optics in 2008: The Poynting Vector and Angular Momentum of Airy Beams, Optics & Photonics News, 19, p. 23 (2008).

    S-K. Zhang, W. Wang, R. R. Alfano, A. M. Dabiran, A. Osinsky, A. M. Wowchak, B. Hertog, P. P. Chow Injection and avalanche electroluminescence of Al0.1Ga0.9N/Al0.15Ga0.85N multiple quantum wells, IEEE J. Sel. Top. Quant. Electron., 14, pp. 1010-1013 (2008).

    Sztul, H.I., Alfano, R.R. The Poynting vector and angular momentum of Airy beams, Opt. Exp., Vol. 16, No. 13, pp. 9411-9416 (2008).

    Pu Y., Wang W.B., Das B.B., Achilefu S., Alfano R.R. Time-resolved fluorescence polarization dynamics and optical imaging of Cytate: a prostate cancer receptor-targeted contrast agent, Appl. Opt., Vol. 47, No. 13, pp. 2281-2289 (2008).

    Kartazaev V., Alfano R.R. Polarization properties of SC generated in CaF2, Opt. Commun., Vol. 281, No. 3, pp. 463-468 (2008).

    Ni X., Alfano R.R. Periodic filamentation and supercontinuum interference, Self-focusing: Past and Present, Vol. 114, Chap. 10, pp. 253-263 (2008).

    Sriramoju V., Savage H.E., Katz A., Chakraverty R., Budansky Y., Podder R., Davatgarzadeh N., Kartazayev U., Rosen R.B., Alfano R.R. NIR-laser tissue welding in an in vivo guinea pig animal model, Optical Interactions with Tissue and Cells XIX, Proc. of SPIE, Vol. 6854, 685405 (2008).

    Liu C.-H., Sriramoju V., Wang W.B., Frankfurt M., Zadeh N.D., Alfano R.R. Study of lipid rich compositions in the intimal wall of aorta by Raman spectroscopy, Biomedical Optical Spectroscopy, Proc. of SPIE, Vol. 6853, 68531E (2008).

    Alfano R.R., Petricevic V., Bykov A. Cr4+-Doped Mixed Alloy Laser Materials and Lasers and Methods Using the Materials, U.S. Patent Office, #7,359,415 B1 (2008).

    Alfano R.R., Petricevic V., Bykov A. Tetravalent Chromium Doped Laser Materials and NIR Tunable Lasers, U.S. Patent Office, #7,440,480 B2 (2008).

    Alfano R.R., Bykov A., Petricevic V., Sharonov M. Cr3+-Doped Laser Materials and Lasers and Methods of Making and Using, U.S. Patent Office, #7,460,574 B2 (2008).

    Alfano R.R., Demos S. Key Secrets of Biospectroscopy, Webcast, BioOptics World magazine, Oct. 29, 2008 (2008).

    Editors: Mahadevan-Jansen A., Petrich W., Alfano R.R., Katz A. Biomedical Optical Spectroscopy, Proc. of SPIE, Vol. 6853 (2008).

    Xu M., Alrubaiee M., Gayen S. K., Alfano R. R. Optical diffuse imaging of an ex vivo model cancerous human breast using independent component analysis, IEEE Journal of Selected Topics in Quantum Electronics, Volume 14, Number 1, Publisher: IEEE Lasers and Electro-Optics S (2008).

    X. Zhou, S. K. Zhang, W. B. Wang, R. R. Alfano, H. Lu, M. C. Tamargo, A. Shen, C. Y. Song, and H. C. Liu Interband and intersubband properties of doped n-ZnCdSe/ZnCdMgSe multiple quantum wells for intersubband device applications, IEEE Journal of Selected Topics in Quantum Electronics, 14, 1042 (2008).

    Sriramoju V., Alimova A, Chakraverty R., Katz A., Gayen, S. K., Larsson L., Savage H. E., Alfano, R. R. Raman spectroscopic study of oxidative stress induced changes in mice skeletal muscles, Conference Name: Biomedical Optical Spectroscopy/ Photonics West, SPIE, Published in Proceedings of SPIE, Volume 6853, Pages 685315-1 - 4; DOI#: 10.1117/12.761277; Locati (2008).

    Balogh-Nair V., Byro A., Wang F., Muthukattil R., Tse Y. F., Nguyen H., Das B. B., Alfano R. R. , and Gayen S. K. Synthesis and optical spectroscopic properties of multivalent and biocompatible hybrid cadmium sulfide-dendrimer nanocomposites, Conference Name: Era of Hope, Department of Defense Breast Cancer Research Program Meeting, Abstract in p.310 of the Conference Proceedings; Conference Loca (2008).

    Xu M., Alrubaiee M, Gayen S. K., and Alfano R. R. Optical tomography using Independent Component Analysis, Conference Name: Era of Hope, Department of Defense Breast Cancer Research Program Meeting, Abstract in in p.292 of the Conference Proceedings; Location of (2008).

    Alrubaiee M., Gayen S. K., and Alfano R. R. Near-infrared time-resolved and spectroscopic imaging for breast cancer detection, Conference Name: Era of Hope, Department of Defense Breast Cancer Research Program Meeting, Abstract in p.293 of the Conference Proceedings, Conference Loca (2008).

    Gayen, S. K., Xu M., Alrubaiee M., Alfano, R. R. Optical imaging of an ex vivo model cancerous human breast using Independent Component Analysis, Conference Name: Era of Hope, Department of Defense Breast Cancer Research Program Meeting, Abstract in p.281 of the Conference Proceedings; Conference Loca (2008).

    Gayen, S K; Brito, M; Das, B B; Comanescu, G; Liang, X C; Alrubaiee, M; Alfano, R R; Gonzalez, C; Byro, A H; Bauer, D L V; Balogh-Nair, V. Synthesis and optical spectroscopy of a hybrid cadmium sulfide-dendrimer nanocomposite,, /vjbo.osa.org/virtual_issue.cfm <http://vjbo.osa.org/virtual_issue.cfm>, Vol. 3, issue 1, January 29, 2008 (2008).

    Shen A., Lu H., Charles W., Yokomizo I., Tamargo M. C., Franz K. J., Gmachl C., Zhang S. K., Zhou X., Alfano R. R., Liu H. C. Intersubband absorption in CdSe/ZnxCdyMg1?x?ySe self-assembled quantum dot multilayers, Applied Physics Letters, 9071910 (2007).

    Zhang S. K., Lu H., Wang W. B., Das B. B., Okoye N., Tamargo M. C., Alfano R. R. Radiative and nonradiative recombination processes in ZnCdSe/ZnCdMgSe multi-quantum wells, Journal of Applied Physics, 10123111 (2007).

    Ni X., Alfano R.R. Supercontinuum generation and applications, Nonlinear Optics and Applications, (2007).

    Alimova A., Roberts M., Gottlieb P. Effects of smectite clay on biofilm formation by microorganism, Biofilms, 3, 47-54 (2007).

    Gayen S.K., Brito M., Das B.B., Comanescu G., Liang X.C., AL-Rubaiee M., Alfano R.R., Gonzalez C., Byro AH., Bauer D.L.V., Balogh-Nair V. Synthesis and optical spectroscopy of a hybrid cadmium sulfide-dendrimer nanocomposite, Journal of Opt. Soc. Am., B24, 3064-3071 (2007).

    Sharonov M. V. A., Alfano R.R. Continuous tunable laser operation in both the 1.31 and 1.55 �m telecommunication windows in Liln(Si/Ge)O4 olivines doped with trivalent chromium, Opt. Lett, 32, 3489-3491 (2007).

    Sharonov M., Myint T. A.B.V., Alfano R.R. Optical properties of neodymium activated crystalline nanostructures grown in transparent porous glass, Journal of Opt. Soc. Am., B24, 2868-2876 (2007).

    Kartazaev V., Alfano R.R. Supercontinuum generated in calcite with chirped femtosecond pulses, Opt. Lett., 32, 3293-3295 (2007).

    Valappil N., Luberto M., Menon V.M., Zeylikovich I., Gayen T.K., Franco J., Das B.B., Alfano R.R. Solution processed microcavity structures with embedded quantum dots, Photonics and Nanostructures: Fudamentals and Applications, 5, 184-188 (2007).

    Zeylikovich I. M.C., Alfano R.R. High resolution ultraviolet-to-visible image conversion using self-assembled CdSe/ZnCdMgSe quantum dot photoluminescence, Journal of Phys. B: At. Mol. Opt. Phys., 40, S373-S378 (2007).

    Zeylikovich I., Sztul H.I., Kartazaev V., Le T., Alfano R.R. Ultrashort Laguerre-Gaussian pulses ith Angular and Group Velocity Dispersion Compenstion, Opt. Lett., 32, 2025-2027 (2007).

    Shen A., Lu H., Tamargo M.C., Charles W., Yokomizo I., Song C.Y., Liu H.C. S.K. X., Alfano R.R., Franz K.J., Gmachl C. Intersubband Transitions in molecular-Beam-Epitaxy-grown Wide Bandgap II-VI Semiconductors, Journal of Vac. Sci. technol., B25, 995-998 (2007).

    Gayen S. K., Gonzalez C., Balogh-Nair V., Brito M., Das B. B., Comanescu G., Liang X. C., Byro A. H., Bauer D. L. V. , Alrubaiee M., and Alfano, R. R. Optical Spectroscopy of a Hybrid CdS-Dendrimer Nanocomposite, J. Opt. Soc. Am., B 24, 3064 (2007).

    Sharanov M. A.B., Myint T. V., Alfano R.R. Spectroscopic Study of Chromium-Doped Transparent Calcium Germanate Glass-Ceramics, Opt. Commun., 275, 123-128 (2007).

    Pu Y., Wang W.B., Achilefu S., Das B.B., Tang C.G., Sriramoju V., Alfano R.R. Time Resolved Fluorescense Polarization Anisotropy and Optical Imaging of Cybesin in Cancerous and normal Prostate Tissues, Opt. Commun., 274, 260-267 (2007).

    Zhang S. K., Lu H., Wang W. B., Das B. B., Okoye N. M. C., Alfano R. R. Radiative and nonradiative recombination processes in ZnCdSe/ZnCdMgSe multi-quantum wells, Journal of Applied Physics, 101, 023111 (2007).

    Shen A., Lu H. M.C., Charles W., Yokomizo I., Franz K.J., Gmachl C., Zhang S.K., Zhou X., Alfano R.R. Intersubband Absorption inCdSe/ZnxCdyMg1-x-ySe Self-Assembled Quantum Dots Multilayers, Appl. Physics. Lett., 90, 071910, 3 pp. (2007).

    Alimova A. A., Katz A.,Sriramoju V., Budansky Y., Bykov A.A., Zeylikovich R., Alfno R.R. Hybrid Phosphorescence and Fluorescence Native Spectroscopy for Breast Cancer Detection, Journal of Biomed., Opt. 12, 014004, 6 pp. (2007).

    Ni X., Kartazayeva S. A., Wang W. B. S. K., Alfano R. R. Polarization memory effect and visibility improvement of targets in turbid media, Proc. SPIE 6434, (2007).

    Xu M., Alrubaiee M. S.K., Savage H., Alfano R.R. Optical High Resolution Cross Section Imaging of a Human Breast Model using independent component analysis, Proc. SPIE 434,, (2007).

    Xu M., Alrubaiee M. S.K., Alfano R.R. Determination of Light Absorption, Scattering and Anisotropy Factor of a Highly Scattering Medium Using Back Scattered Circularly Polarized light, Proc. SPIE 6435, (2007).

    Sztul H.I., Kartazayev V., Alfano R.R. Langerre-Gaussian Supercontinuum, Proc. SPIE 6483, (2007).

    Xu M., Alrubaiee M. S. K., Alfano R. R. Determination of light absorption, scattering and anisotropy factor of a highly scattering medium using backscattered circular polarized light, Proceedings of SPIE, vol. 6435, 64350J, (2007).

    Ni X., Kartazayeva S. A., Wang W. B., Cai W. S. K., Alfano R. R. Polarization memory effect and visibility improvement in turbid media, Proceedings of SPIE,, vol. 6434, 64340N (2007).

    Xu M., Alrubaiee M.S. K., Alfano R. R. Optical high resolution cross section imaging of a human breast model using independent component analysis in CW and time domain, Proceedings of SPIE,, vol.6434, 643416 (2007).

    Sharonov M. Yu., Myint T., A.B., V., Alfano R.R. Optical properties of neodymium activated crystalline nanostructures grown in transparent porous glass, Journal of Opt. Soc. Am. B, 24, 2868-2876 (2007).

    Sharanov M.A.B. V., Alfano R. Continuous tunable laser operation in both the 1.31 and 1.55 mm telecommunication windows in LiLnSi/GeO4 olivines doped with trivalent chromium, OpticsLetters, 32, 3489-3491 (2007).

    Sharanov M.Yu. A.B., Myint T. V., Alfano R.R. Spectroscopic study of chromium-doped transparent calcium germanate glass-ceramics, Optics Communications, 275, 123-128 (2007).

    I. Zeylikovich, G. C. Tang, A. Katz, Y. Budansky, and R. R. Alfano Fluorescence-based micro-endoscopes for breast cancer ductoscopy, Optical Biopsy VI, 6091, 1-4, SPIE Proceedings (2006).

    Vidyasagar Sriramoju, Howard E. Savage, Rabindra Halder, Richard B. Rosen, A. Katz, and R. R. Alfano Heat management prevents tissue buckling and collateral damage in NIR-laser welding, Photonic Therapeutics and Diagnostics II, V0698, 168-171, SPIE Proceedings (2006).

    Vidyasagar Sriramoju, R. Podder, N. Davatgarzadeh, Howard E. Savage, Richard B. Rosen, A. Katz, and R. R. Alfano Heat management using thermal conductive optical windows for the prevention of tissue buckling and collateral damage in NIRlaser tissue welding, Optical Imaging Workshop, NIH Workshop (2006).

    Alexandra Alimova, A. Katz, Vidyasagar Sriramoju, Yuri Budansky, Alexei A. Bykov, Roman Zeylikovich, and Alfano Hybrid native phosphorescence and fluorescence spectroscopy for cancer detection, Optical Biopsy VI, V. 6091 22-25 SPIE Proceedings (2006).

    A. Alimova, A. Katz, P. Gottlieb, and R. R. Alfano Proteins and dipicolinic acid released during heat shock activation of Bacillus subtilis spores probed by optical spectroscopy, Applied Optics, V45(3) 445-450 (2006).

    Alexandra Alimova, Karin Block, Elizabeth Rudolph, A. Katz, J. C. Steiner, P. Gottlieb, and R. R. Alfano Bacteria-clay interactions investigated by light scattering and phase contrast microscopy, Optical Diagnostics and Sensing VI, V6094 76-79 SPIE Proceedings (2006).

    Alimova A., Roberts M., Katz A., Rudolph E., Steiner J.C., Alfano R.R., Gottlieb P. Effects of smectite clay on biofilm formation by microorganism, Biofilms, 3(1), 47-54 (2006).

    Cai W., Ni X., Gayen S. K., Alfano, R. R. Analytical cumulant solution of the vector radiative transfer equation investigates backscattering of circularly polarized light from turbid media, Physical Review E, Volume 74, Article #: 056605, American Institue of Physics, NY (2006).

    Alrubaiee M., Xu M, Gayen S. K., Alfano R. R. Three-dimensional localization and cross section reconstruction of fluorescent targets in ex vivo breast tissue using independent component analysis, Applied Physics Letters, American Institute of Physics, Vol. 87, Article # 191112, Page: 191112-1 - 191112-3 (2006).

    Alfano R. R., Ying J., Cai W., and Gayen S. K. Methods of improving line-of-sight wireless optical communication through adverse environmental conditions, U. S. Patent Office, U. S. Patent Number: 7,106,972 (2006).

    Sztul, H. I., and Alfano, R. R. Double-Slit Interference with Laguerre-Gaussian Beams, Optics Letters, 31: 999-1001 (2006).

    Ni, X. and Alfano, R. R. Brillouin Precursor Propagation in the THz Region, Optics Express, 14: 4188-4194 (2006).

    Wang, C., Shumyatsky, P., Zeng, F., Zevallos, M., and Alfano, R. R. Computer-Controlled Optical Scanning Tile Microscope, Applied Optics, 45: 1148-1152 (2006).

    Alimova, A., Katz, A., Gottlieb, P., and Alfano, R. R. Proteins and Dipicolonic Acid Released During Heat Shock Activation of Bacillus Subtilis Spores Probed by Optical Spectroscopy, Applied Optics, 45: 445-450 (2006).

    Yu, B. L., Yang, Y., Zeng, F., Xin, X., and Alfano, R. R. Terahertz Absorption Spectrum of D2O Vapor, Optics Communications, 258: 256-263 (2006).

    Alimova, A., Block, K., Rudolph, E., Katz, A., Steiner, J. C., Gottlieb, P., and Alfano, R. R. Bacteria-Clay Interactions Investigated by Light Scattering and Phase Contrast Microscopy, Proc. of SPIE, 6094: 60940E-1 (2006).

    Zeylikovich, R., Tang, G. C., Katz, A., Budansky, Y., Alfano, R. R. Fluorescence-based Microendoscopes for Breast Cancer Ductoscopy, Proc. of SPIE, 6091:01:00 (2006).

    Alimova, A., Katz, A., Sriramoju, V., Budansky, Y., Bykov, A. A., Zeylikovich, R., and Alfano, R. R. Hybrid Native Phosphorescence and Fluorescence Spectroscopy for Cancer Detection, Proc. of SPIE, 6091:22:00 (2006).

    Phillips, K. G., Xu, M., Gayen, S. K., and Alfano, R. R. Time-Resolved Ring Structure of Backscattered Circularly Polarized Beams from Forward Scattering Layered Structures, Proc. of SPIE, 6091:42:00 (2006).

    Sriramoju, V., Savage, H. E., Halder, R., Rosen, R. B., Katz, A., and Alfano, R. R. Heat Management Prevents Tissue Buckling and Collateral Damage in NIR-Laser Welding, Proc. of SPIE, 6078: 60780Y-1 (2006).

    L. Wang, G. Zhang, J. C. Luo, F. Zeng, Q. Z. Wang, S. A. Alfano, A. Katz, M. Zevallos, and R. R. Alfano Wireless spectroscopic compact photonic explorer for diagnostic optical imaging, Boimedical Microdevices, V.7(2) 111-115 (2005).

    A. Katz, A. Alimova, M. Xu, P. Gottlieb, E. Rudolph, J. C. Steiner, and R. R. Alfano In situ determination of refractive index and size of Bacillus spores by light transmission, Optics Letters, V30(6) 589-591 (2005).

    A. Alimova, A. Katz, M. Siddique, G. Minko, H.E. Savage, M.K. Shah, R.B. Rosen, and R.R. Alfano Native fluorescence changes induced by bactericidal agents, IEEE Sensors Journal, V5(4), 704-711 (2005).

    A. Alimova, A. Katz, R. Podder, G. Minko, H. Wei, J. Berriman, R. R. Alfano, and P. Gottlieb Virus particles and receptor interaction monitored by fluorescence spectroscopy, Photochemistry Photobiology, V81(4), 879-883 (2005).

    Xu M., Alrubaiee M., Gayen, S. K., Alfano R. R. Three-dimensional localization and optical imaging of objects in turbid media using independent component analysis, Applied Optics, Optical Society of America, Vol. 44, Pages 1889-1897 (2005).

    Zevallos M. E., Gayen S. K., Alrubaiee M., Alfano R. R. Time-gated backscattered ballistic light imaging of objects in turbid water, Applied Physics Letters, American Institute of Physics, Vol. 86, Article #: 011115, Pages:011115-1 - 011115-3; DOI#:10.1063/1.1846145 (2005).

    Alfano R. R. The Supercontinuum Laser Source, 2nd ed. Editor, Springer, New York, (2005).

    Zeylikovich, I., Kartazaev, V., and Alfano, R. R. Spectral, Temporal, and Coherence Properties of Supercontinuum Generation in Microstructure Fiber, J. Opt. Soc. Am., B 22: 1453-1460 (2005).

    Phillips, K. G., Xu, M., Gayen, S. K., and Alfano, R. R. Time-Resolved Ring Structure of Circularly Polarized Beams Backscattered from Forward Scattering Media, Opt. Exp., 13: 7954-7969 (2005).

    Xu, M., and Alfano, R. R. Circular Polarization Memory of Light, Phys. Rev. E, 72: 065601-1(R) (2005).

    Xu, M., and Alfano, R. R. Random Walk of Polarized Light in Turbid Media, Phys. Rev. Lett., 95: 213901-213900 (2005).

    Zhang, S. K., Wang, W. B., Dabiran, A. M., Osinsky, A., Wowchak, A. M., Hertog, B., Plaut, C., Chow, P. P., Gundry, S., Troudt, E. O., and Alfano, R. R. Avalanche Breakdown and Breakdown Luminescence of AlGaN Multiquantum Wells, Appl. Phys. Lett., 87: 262113-1 (2005).

    Xu, M. and Alfano, R. R. Fractal Mechanisms of Light Scattering in Biological Tissue and Cells, Opt. Lett. 30, 30: 3051-3053 (2005).

    Xu, M., Alrubaiee, M., Gayen, S. K., and Alfano, R. R. Optical Imaging of Turbid Media Using Independent Component Analysis: Theory and Simulation, J. Biomed. Opt., 10: 051705-1 (2005).

    Alrubaiee, M., Xu, M., Gayen, S. K., Brito, M., and Alfano, R. R. Three-Dimensional Optical Tomographic Imaging of Scattering Objects in Tissue-Simulating Turbid Media Using Independent Component Analysis, Appl. Phys. Lett., 87: 191112-1 (2005).

    Zeng, B. L., Yu, F., Kartazayev, V., Alfano, R. R., and Mandal, K.C. Terahertz Studies of the Dielectric Response and Second-Order Phonons in a GaSe Crystal, Appl. Phys. Lett. 87, 87: 182104-1 (2005).

    Alimova, A., Katz, A., Podder, R., Minko, G., Wei, H., Berriman, J., Alfano, R. R., and Gottlieb, P. Virus Particles and Receptor Interaction Monitored by Fluorescence Spectroscopy, Photochem. Photobiol., 81: 879-883 (2005).

    Yu, M., Sharonov, A. Bykov, B., Rojas, P., Petricevic, V., and Alfano, R. R. Spectroscopy of Chromium Centers in LiScGeO4 and LiInGeO4 Single Crystals, Phys. Rev. B, 72:115111-1 (2005).

    Alfano, R. R., Wang, W. B., and Gayen, S. K. Lasers in Cancer Detection and Diagnosis Research: Enabling Characteristics with Illustrative Examples, Tech. Cancer Res. Treat., 4: 663-674 (2005).

    Alrubaiee, M., Gayen, S. K., Alfano, R. R., and Koutcher, J. A. Spectral and Temporal Near-Infrared Imaging of Ex Vivo Cancerous and Normal Human Breast Tissues, Tech. Cancer Res. Treat., 4: 457-470 (2005).

    Pu, Y., Wang, W. B., Tang, G. C., Zeng, F., Achilefu, S,. Vitenson, J., Peters, H., Sawczuk I. S., Lombardo J. M., and Alfano, R. R. Spectral Polarization Imaging of Human Prostate Cancer Tissue Using a Near-infrared Receptor-targeted Contrast Agent, Tech. Cancer Res. Treat., 4: 429-436 (2005).

    Comanescu, G., Wang, W. B., Gundry, S., Das, B., Alfano, R. R., Perez-Pas, M. N., Tamargo, M. C., Munoz, M., Popov, I., and Isaacs, L. L. Spectroscopy and Carrier Dynamics in CdSe Self-assembled Quantum Dots Embedded in ZnxCdyMg1-x-ySe, Appl. Phys. Lett. 86, 86: 253113-1 (2005).

    Alimova, A., Katz, A, Siddique, M., Minko, G., Savage, H. E., Shah, M. K., Rosen, R. B., and Alfano, R. R. Native Fluorescence Changes Induced by Bactericidal Agents, Fellow, IEEE, IEEE Sens. J., 5: 704-711 (2005).

    Wang, L., Zhang, G. J., Luo, C., Zeng, F., Wang, Q. Z., Alfano, S. A., Katz, A., Zevallos, M., and Alfano, R. R. Wireless Spectroscopic Compact Photonic Explorer for Diagnostic Optical Imaging, Biomed. Microdevices, 7: 111-115 (2005).

    Birman, J., L., Ni, X., Alrubaiee, M., Das, B. B., and Alfano, R. R. Comment on Observation of Optical Precursors in Water', Phys. Rev. Lett. 94, 94: 239401-1 (2005).

    Alrubaiee, M., Xu, M., Gayen, S. K., and Alfano, R. R. Independent Component Analysis for Three-Dimensional Optical Imaging and Localization of a Fluorescent Contrast Agent Target Embedded in a Slab of ex vivo Human Breast Tissue, Proc. of SPIE, 5862:23:00 (2005).

    Yu, B., Alimova, A., Katz, A., and Alfano, R. R. THz Absorption Spectrum of Bacillus Subtilis Spores, Proc. of SPIE, 5727:20:00 (2005).

    Alimova, A., Katz, A., Paul, M., Rudolph, E., Gottlieb, P., Steiner, J. C., and Alfano, R. R. Fluorescence Detection of Proteins released by Bacillus Subtilis Spores during Heat Shock Germination, Proc. of SPIE, 5697:37:00 (2005).

    H. E. Savage, R. K. Halder, U. Kartazayeu, R. B. Rosen, T. Gayen, S. A. McCormick, N. S. Patel, A. Katz, H. D. Perry, M. Paul, and R. R. Alfano NIR laser tissue welding of in vitro porcine cornea and sclera tissue, Lasers in Surgery and Medicine, V35(4), 293-303 (2004).

    A. Alimova, A. Katz, R. Podder, G. Minko, H. Wei, R. R. Alfano, and P. Gottlieb Virus particles monitored by fluorescence spectroscopy: a potential detection assay for macromolecular assembly, Photochemistry Photobioilogy, V80, 41-46 (2004).

    A. Katz, Erik F. Kruger, Glenn Minko, C. H. Liu, Richard B. Rosen, and R. R. Alfano Detection of Glutamate in the Eye by Raman Spectroscopy, Journal of Biomedical Optics, V 8(2), 167-172 (2003).

    A. Katz, Alexandra Alimova, M. Xu, Elizabeth Rudolph, M. Shah, Howard Savage, Richard Rosen, Steven A.. McCormick, and R. R. Alfano Bacteria Size Determination by Elastic Light Scattering, IEEE Journal of Selected Topics in Quantum Electronics, V. 9(2) 277-287 (2003).

    Tapan K. Gayen, A. Katz, Howard E. Savage, Steven A. McCormick, M. Al-Rubaiee, Y. Budansky, John Lee, and R. R. Alfano Alfano, Aorta and Skin Tissues Welded By Near-Infrared Cr4+:YAG Laser, Journal of Clinical Laser Medicine & Surgery, V. 21(5) 259-269 (2003).

    Alexandra Alimova, A. Katz, Howard E. Savage, M. Shah, Glenn Minko, Daniel V. Will, Richard B. Rosen, Steven A. McCormick, and R. R. Alfano Native Fluorescence and Excitation Spectroscopic Changes in Bacillus subtilis and Staphylococcus aureus Bacteria Subjected to Conditions of Starvation, Applied Optics, V. 42(19) 4080-4087 (2003).

    A. Katz, Howard E. Savage, Stimson P. Schantz, Steven A. McCormick, and R. R. Alfano Noninvasive Native Fluorescence Imaging of Head and Neck Tumors, Technology in Cancer Research and Treatment, V. 1(1) 9-16 (2002).
  • Additional Information

    Coherent Award for Lifetime Achievement in Biophotonics (2002)
    Optical Society of America Charles Hard Townes Award (2008)
    SPIE Britton Chance Biomedical Optics Award (2012)
    APS  Arthur L Schawlow Prize in Laser Science (2013)
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