Dr. Karen Hubbard joined our Area Group II in Fall 1995. Dr. Hubbard was a Research Assistant Professor at UMDNJ-New Jersey Medical School. She studies senescence using SV-40 transformed human epithelial cells as a model system.
RESEARCH
Regulation of Gene Expression in Cellular Senescence
Normal human fibroblasts have a finite life span when cultured in vitro. This terminal growth phase has been termed cellular aging or senescence. Recent studies have shown that there are many striking correlations between aging at the organismal and cellular levels. The focus of the laboratory is to investigate regulation of gene expression during cellular senescence. We have identified alterations in the levels and activities of proteins which are involved in the processing of procurer RNA into mature messenger RNA. Thus far, the role of post-transcriptional processing of RNA has not been studied in cellular aging. We will examine the developmental contributions of post-transcriptional processing with respect to cellular aging in human fibroblasts.
Selected Publications:
Ji, F., Pierre, Z., Liu, S., Hwang, B.-J., Hill, H., Hubbard, H., and Steinberg, M. (2006) Novel UVB-induced mitochondrial deletions in human epithelial cells irradiated in vitro. J. Photochem. Photobiol. (In Press). *
Zhou, D., Xu, G., Ghandhi, S. and Hubbard, K. (2002) Modulation of the expression of p16INK4a and p14ARF by hnRNP A1 and A2 RNA binding proteins: Implications for cellular senescence. J. Cell Phys. 193:19-25.
Seifer, D.B., DeJesus, V., and Hubbard, K. (2002) Mitochondrial deletions in lutenized granulosa cells as a function of age in women undergoing in vitro fertilization. Fertilization & Sterility. 78:1046-1048.
DeJesus, V., Rios, I., Davis, C. , Chen, Y., Calhoun, D., Zakeri, Z. and Hubbard, K. (2002) Induction of apoptosis in human senescent human fibroblasts. Exp. Cell Res. 274:92-99.
Location and Contact Information:
Dr. Karen Hubbard
Department of Biology, Room J526
City College of New York
138th Street & Convent Avenue
New York, NY 10031
t. 212.650.8566
t. 212.650.8561 Lab
khubbard@scisun.sci.ccny.cuny.edu
Other Locations: J631 and J627