Biomedical Engineering Graduate Course Descriptions

BME I0000 Biomedical Engineering Seminar
Recent developments in biomedical engineering given by invited academic and industrial speakers.
Prerequisites: none. 1 hour/week; 0 credits.

BME I2000 Cell and Tissue Engineering
The course covers the underlying mechanisms of cell/tissue fate processes and their interaction with biomaterials as well as how to study them quantitatively using engineering methods. Students will gain knowledge of current products of bioartificial organs in research, clinical trials and industry, their limitations and prospects. The course will prepare students the ability to identify challenges in the field of tissue engineering and provide feasible solutions through the writing of term papers in the format of a research proposal. Prerequisites: Undergraduate cell and molecular biology and biochemistry. 3 hours/week; 3 credits.

BME I2200 Cell and Tissue Transport
The course will start with an analysis of water, solute, gas, and heat exchange in the microcirculation and the relationship between structure and function. Active transport across membranes will be considered and applied to the kidney and secretory organs. Transport in biological porous media will be examined and applied to bone, cartilage, and arterial wall. An introduction to receptors and their role in transport, cell adhesion, and intracellular signaling will be presented. The course will conclude with student presentations on topics of current interest.
Prerequisite: Undergraduate fluid mechanics or transport course. 3 hours/week; 3 credits.

BME I3000 Neural Engineering and Applied Bioelectricity
An overview of the field of neural engineering including neuronal biophysics, synaptic and non-synaptic communication, electrophysiological techniques, field potential and current source density analysis. The course introduces fundamentals of applied bioelectricity/electrical prosthetic (FES) including electric field-neuronal interactions and electrocution hazards. Prerequisite: An undergraduate circuits course. 3 hours/week; 3 credits.

BME G3200 Neural Systems and Behavior
This course focuses on the neural mechanisms underlying behavior. It covers the fundamentals of psychophysics and behavioral modeling; introduces perceptual and cognitive neural systems and some of the ways we measure signals transmitted within those systems; and it entails presentation and discussion of a range of systems neuroscience research, emphasizing studies that A) invoke uncomplicated but effective mathematical models to understand perceptual and cognitive processes, and/or B) establish concrete relationships between brain signals and behavior. Some studies will be presented by the authors themselves in guest lectures. The course will involve MATLAB programming assignments for behavioral task design, modeling and data analysis.

BME I4200 Organ Transport and Pharmacokinetics
Application of basic transport principles (conservation of mass and momentum equations) to major animal and human organ systems. Topics include mechanisms of regulation and homeostasis, anatomical, physiological, and pathological features of the cerebral, respiratory, renal, cutaneous and gastrointestinal systems. Basic
concepts in pharmacokinetic analysis for drug administration are also discussed. Related and recent research articles will be discussed. Students will be guided to write up a proposal for a topic of interest.
Prerequisite: Undergraduate fluid mechanics or transport course. 3 hours/week; 3 credits.

BME I4300 Physiology for Biomedical Engineers
This course is designed to provide biomedical engineering students with a comprehensive understanding of the principles of human physiology. It covers a broad range of topics, from cellular physiology to the physiology of organs and organ systems. The course includes units devoted to the study of membrane solute transport, nerve
and muscle functions, functions of the autonomic nervous system, cardiovascular system as well as renal, respiratory, gastrointestinal and endocrine systems. Instructional activities include lectures, case presentations, laboratories, and special conferences.
Prerequisite: Students with no biology background should complete an undergraduate biology course before taking this course. 7 hours/week; 6 credits.

BME I5000 Medical Imaging and Image Processing
This course introduces basic medical imaging methods such as computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET). Students will gain understanding in the basic physics of image acquisition and the algorithms required for image generation. Basic image enhancement, and image analysis will be presented in the context of X-ray imaging and microscopy. The course will include linear systems, random variables, and estimation theory. Students will gain hands-on experience in image processing through MATLAB programming in class and in assignments.
Prerequisites: An undergraduate linear systems course and an undergraduate linear algebra course. 3 hours/week; 3 credits.

BME I5100 Biomedical Signal Processing
This course introduces two fundamental concepts of signal processing: linear systems and stochastic processes. Various estimation, detection and filtering methods are developed and demonstrated on biomedical signals. The methods include harmonic analysis, auto-regressive model, Wiener and Matched filters, linear
discriminates, and independent components. All methods will be developed to answer concrete questions on specific data sets such as electro-cardiograms, electro-encephalography, acoustic signals, or neural spike trains. The lectures will be accompanied by data analysis assignments using MATLAB.
Prerequisites: An undergraduate linear systems course and an undergraduate linear algebra course. 3 hours/week; 3 credits.

BME I7000 Laboratory in Cellular and Molecular Engineering
The course covers current biotechnologies used in molecular, cell and tissue engineering research labs as well as biotech industries through lectures and hands-on labs. There are four modules: (1) cell processing, basic microscopy & tissue engineering, (2) gene manipulation and genetic engineering, (3) advanced microscopy and
fluorescent probes and (4) probing biocomplexity and protein analysis. The students are required to design their own experimental methods to solve the given biomedical problems according to the basic protocols in manuals/books/papers provided by the instructor.
Prerequisites: Bio 22900 and BME 31000, or equivalent. 4 hours/week; 3 credits.

BME I7100 Cell and Tissue Mechanics
Mechanical properties of hard and soft tissue are presented with emphasis on the stress adaptive processes that enable cells to adapt the mechanical/structural properties of tissue in which they live to the environment they experience. Topics to be covered include whole body biomechanics, occupational and sports injury, impact
biomechanics, and tissue level biomechanics. The biomechanics of implants and cell biomechanics will be described briefly and their interrelationship explored. The mechanical properties of tissues will be reviewed, with an emphasis on the structure-function relationship. The stress adaptive mechanisms of tissues will be
noted, with special emphasis on the stress adaptation observed in bone (Wolff's law) and in the arterial wall (Murray's law). The structural properties of cells, including their strength, deformability , and adhesive properties, will be covered, as well as the adaptation of cell structural properties. Cell receptors and cell
signaling mechanisms will be described.
Prerequisites: Undergraduate strength of materials course and ENGR I4200 Continuum Mechanics. 3 hours/week; 3 credits.

BME I7300 Cell and Tissue - Biomaterial Interactions
This course is concerned with the reaction and interaction of both inert and bioactive foreign materials placed in the living human body. Topics to be discussed include atomic structure and bulk properties of the major classes of implantable materials; biocompatibility; characterization of non-living biomaterials; reaction of biological
molecules with biomaterial surfaces; host response to implants; hemocompatibility; effects of degradation on implant materials; bioactive surfaces; resorbable implant materials; standardization, sterilization and regulation of implant materials; in vitro and in vivo biomaterial testing methods; and introduction to tissue engineering.
Case studies and presentations of current literature focusing on novel materials and new clinical applications will also be included to identify future directions in biomaterials research. Prerequisite: Undergraduate materials or transport course. 3 hours/week; 3 credits.

BME I7700 Microfluidic Devices in Biotechnology
Fundamentals of modern microfluidic devices with applications to biomedical measurements, e.g., electrophoretic systems, flow cytometers, and immunoassays. Review of fundamental properties of microfluidic systems including the effects of fluid mechanics, heat transfer, and electromagnetic phenomena on biological systems. Theory of Navier-Stokes, Nerst-Planck and convection transfer equations will be discussed. Critical overview of design, manufacture, and operation of micrometer scale
systems that use photolithographic and surface treatment techniques for device development. Special projects will also be used to analyze biomedical inventions on the horizon.
Prerequisites: Undergraduate courses in fluid mechanics and differential equations. 3 hours/week; 3 credits.

BME I8000 Bone Physiology and Biomechanics

This course is concerned with the normal mechanical and biological functions of bone, as well as the clinical problems in metabolic bone disease and orthopaedic treatment. Specific topics will examine how bone cells produce matrix material and structure, restructure it during life to optimize bone mechanical function, and then
maintain the material vs. structural properties throughout life. Bone organ, tissue and cellular-molecular level processes will be examined as integrated hierarchical systems contributing to mechanical function, presented from lectures, case studies and presentations of critical literature identifying central principles in bone
biomechanics. Discussions will seek to identify fundamental questions and directions for future research.
Prerequisites: Undergraduate courses in physiology, cell biology, and mechanics, or permission of the instructor. 3 hours/week; 3 credits

BME I9000 Skeletal Soft Tissue Physiology and Biomechanics
This course is concerned with the physiology and biomechanics of the skeletal soft tissues (cartilage, tendon, ligament, intervertebral disc). The course will examine how specialized connective tissue cells produce their matrices and organize them hierarchically into tissues with unique mechanical properties. How tissue and biomechanical properties of the various skeletal soft tissues are maintained in life or fail in skeletal disease will also be examined. Case studies and presentations of critical literature will be used to identify fundamental questions and directions for future research.
Prerequisites: Undergraduate courses in physiology, cell biology, and mechanics, or permission of the instructor. 3 hours/week; 3 credits

BME I9300 Scientific Ethics
This ethics course will introduce integrity in scientific research. The topics include scientific misconducts (fabrication, falsification, plagiarism), authorship, being a graduate student, writing lab notes, writing research articles, obtaining funding, developing intellectual property, job hunting, being professional. It will also discuss
the societal impact of biotechnology, nanotechnology and information technology.
Prerequisites: none. 1 hour/week; 1 credit.

BME I9500 Entrepreneurship and Financial Economics
Technological innovation has led to the development of an extraordinary number of new and emerging growth companies. The purpose of this course is to provide a practical exposure to the methods used, for students of all backgrounds. Strengths upon leaving this course arise from the diverse student interaction and content
presented by an instructor with real-world, decision-making experience in all topics covered. Creative problem solvers for economic development and recovery are in high demand, and success will require innovation, not only in new products and services, but in the development of new business models themselves. Class participation and projects using real funds are implemented.
Prerequisites: none. 2 hours/week; 2 credits.

BME G6000 Advanced Biomaterials
This course is concerned with the design and fabrication of advanced biomaterials for clinical applications. The major classes of materials and characterization methods are presented to provide a foundation for more specialized topics focusing on novel materials with tailored structural and biological properties to facilitate interactions with living tissue. Topics to be discussed include surface modification to engineer cell-instructive materials, self-assembled and nanostructured materials, hybrid composite materials, environmentally responsive “smart” biomaterials, and decellularized natural matrices.
Prerequisites: Undergraduate or graduate course in biomaterials. 3 hours/week; 3 credits

ENGR I4200 Continuum Mechanics
Continuum kinematics, formulation of physical principles in the continuum context, the formulation of constitutive equations, the theories of elastic solids, viscous fluids and viscoelastic solids. At the end of the course there will be an emphasis on either deformable porous media or finite deformation elasticity, depending on student
Prerequisites: Basic undergraduate courses in Mechanics of Materials, Fluid Mechanics and Linear Algebra (including vector field theory). 3 hours/week; 3 credits

ENGR I7500 Poroelasticity
Incorporating elastic solid properties and Darcy’s law, Biot poroelasticity is a model for interaction of stress and fluid flow in a porous medium. The Biot model is used to solve quasistatic problems containing creep, stress relaxation and consolidation as well as wave propagation problems, including the “second sound” prediction and verification. The Biot model is then extended as a continuum mixture model suitable for a description of the mechano-electro-chemical behaviors associated with deformation and fluid flow in charged-hydrated porous materials. This mixture model provides a flexible and general basis that permits the development of a unified
viewpoint for many diverse and perhaps simultaneously occurring phenomena.
Prerequisites: Courses in partial differential equations (ENGR I1400) and continuum mechanics (ENGR I4200)
(or a course in elasticity and fluid mechanics that included viscous fluid theory). 3 hours/week; 3 credits.

BME I9800 Project
A research project performed under the supervision of a faculty mentor. A final written report is required.
Prerequisite: Approval of the departmental master’s advisor. 3 credits.

BME I9700 Report
In-depth analysis of a specific biomedical engineering topic by means of a written report that utilizes a number of technical sources. Topic to be chosen by the student in consultation with a supervising faculty member.
Prerequisite: Completion of 12 credits toward the master’s degree in Biomedical Engineering. 0 credits.

BME I9906 Research for the Master’s Thesis
Prerequisite: Approval of the departmental master’s advisor. 3-6 credits.
BME J9900 Research for the Doctoral Dissertation
Variable credits, up to 12 credits.