Andreas H. Kottmann
Associate Medical Professor
Ph.D., 1991, Max Planck Institute for Immunobiology and Albert Ludwig University Freiburg, Germany
M.S., 1984, University of Cologne, Germany
Dr. Kottmann's research aims to understand the regulation of competitive processes that on one side lead to the structural and functional stability of the central nervous system throughout life while allowing at the same time structural and functional plasticity necessary for learning and memory. We focus our efforts on the reciprocal interactions of the ascending dopaminergic system of the mesencephalon and the cholinergic system of the basal forebrain, and the spinal motor neuron system. Our basic research is of relevance to two prominent, progressive neurodegenerative disorders, Parkinson's Disease and Amyotrophic Lateral Sclerosis (ALS).
- Neurogenesis in the adult CNS
- Basal Ganglia Function
- Muscle Plasticity and Repair
- Parkinson's Disease and Basal Ganglia Disorders
- Modeling Progressive Neurodegenerative Diseases by Recombinant DNA Technologies in Mice
- Visualization and Manipulation of Basal Ganglia and Spinal Motor Circuits by Genetic Gene Expression Tracing and Viral Transduction Techniques.
- Personalized Medicine Approaches in Psychiatry, Neurology and Oncology
Gonzalez-Reyes, Luis E., Miguel Verbitsky, Javier Blesa, Vernice Jackson-Lewis, Daniel Paredes; Karsten Tillack, Sudarshan Phani, Edgar R. Kramer, Serge Przedborski, and Andreas H. Kottmann (2012) "Sonic Hedgehog Maintains Cellular and Neurochemical Homeostasis in the Adult Nigrostriatal Circuit". Neuron 2012;75 (2): 306–319
Desouza, Lynette A., Malini Sathanoori, Richa Kapoor, Neha Rajadhyaksha, Luis Gonzalez-Reyes, Andreas H. Kottmann, Shubha Tole, Vidita A. Vaidya(2011)"Thyroid hormone regulates the expression of the sonic hedgehog signaling pathway in the embryonic and adult mammalian brain. Endocrinology".2011: 152(5):1989-2000
Kolterud A, Grosse AS, Zacharias WJ, Walton KD, Kretovich KE, Madison BB, Waghray M, Ferris JE, Hu C, Merchant JL, Dlugosz AA, Kottmann AH, Gumucio DL. (2009) "Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning". Gastroenterology. 2009 Aug;137(2):618-28.
Schwegmann A, Guler R, Cutler AJ, Arendse B, Horsnell WG, Flemming A, Kottmann AH, Ryan G, Hide W, Leitges M, Seoighe C, Brombacher F. (2007) "Protein kinase C delta is essential for optimal macrophage-mediated phagosomal containment of Listeria monocytogenes". Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16251-6. Epub 2007 Oct 3
Yun SW, Platholi J, Flaherty MS, Fu W, Kottmann AH, Toth M (2006) "Fmrp is required for the establishment of the startle response during the critical period of auditory development". Brain Research. Brain Research. 1110: 159-165.
Leonardo E.D.; J. W. Richardson-Jones; E. Sibille; A. H. Kottmann; R. Hen, (2005) "Molecular Heterogeneity along the Dorsal-Ventral Axis of the Murine Hippocampal CA1 field: A microarray analysis of gene expression". J. Neuroscience 137: 177-186
Jeong J., J. Mao, T. Tenzen, A.H. Kottmann and A.P. McMahon (2004) "Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordial" Genes and Development 18: 937 – 951.
Lewis PM., A. Litli-Grinde, R. Smeyne, A.H. Kottmann and A.P. McMahon (2004) "Sonic Hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum". Development, 270: 393-410.
Brown LE., A.H. Kottmann, and S.Brown (2003) "Immunolocalization of Zic2 expression in the developing mouse forebrain." Gene Expr. Patterns 3: 361-7.
Kalachikov S., O Evgrafov, B Ross, M Winawer, C Barker-Cummings, F P Boneschi, C.Choi, P Morozov, K Das, E Teplitskaya, A Yu, E Cayanis, G Penchaszadeh, A.H. Kottmann, T A. Pedley, W. A. Hauser, R Ottman and T. C. Gilliam (2002) "Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features". Nature Genetics 30: 335 – 341
Zou Y-R., A.H. Kottmann, M. Koruda, I. Taniuchi and D.R. Littman (1998) "Function of the Chemokine Receptor CXCR4 in Haematopoiesis and in Cerebellar Development" Nature 393: 595-598