Share This

Antonio Mantovani

Faculty and Staff Profiles

Antonio Mantovani

Assistant Medical Professor

School/Division
Office
Harris Hall 201C
Phone Number: 
212-650-5417
Fax: 
212-650-7726
Email: 
Amantovani@med.cuny.edu
Antonio Mantovani
Heading: 
Profile
Description: 

Dr. Mantovani has been serving as Assistant Professor of Neuropsychiatry at CUNY School of Medicine since 2014. Dr. Mantovani is director of the Brain Stimulation Service, where he coordinates the application of non-invasive brain stimulation (Transcranial Magnetic Stimulation-TMS, transcranial Direct Current Stimulation-tDCS) in combination with MRI, EEG, and MEP recordings to study the pathophysiology of neuropsychiatric disorders and to test the therapeutic effect of focal brain stimulation in treatment-resistant conditions. Before moving to CUNY, Dr. Mantovani was a Research Scientist and an Assistant Professor of Clinical Psychiatry at the New York State Psychiatric Institute and Columbia University College of Physicians and Surgeons. 

Heading: 
Education
Description: 

M.D., 1997, Universita’ Cattolica del Sacro Cuore, Rome, Italy

Psychiatry residency, 2003, Universita’ degli Studi di Siena, Siena, Italy

Ph.D. Applied Neurological Sciences, 2008, Universita’ degli Studi di Siena, Siena, Italy

Post-Doctoral Research Fellowship in Psychiatry, 2008, Columbia University Department of Psychiatry, New York, USA

Alexander Bodini Fellowship in Developmental and Adolescent Psychiatry, 2009, Italian Academy for Advanced Studies in America, New York, USA

Post-Doctoral Research Fellowship in Psychiatry, 2011, Dipartimento di Neuroscienze, Universita’ degli Studi di Siena, Siena, Italy

Heading: 
Courses Taught
Description: 

Neuropsychiatry

Behavioral Medicine

CME course in TMS and tDCS

Heading: 
Research Interests
Description: 

Dr. Mantovani has training in psychiatry, neurophysiology, and in both invasive and non-invasive brain stimulation techniques (e.g. DBS, VNS, TMS and tDCS). He has extensive expertise in the design and conduct of TMS and tDCS clinical trials, having trained in the laboratory of Dr. Simone Rossi at Siena University where he obtained his Ph.D. in applied neurological sciences, and subsequently during a postdoctoral fellowship at Columbia University under the mentorship of Dr. Sarah H. Lisanby.

Dr. Mantovani research interest is in the examination of neuroimaging, neurophysiological, and neurocognitive measures before and after the application of non-invasive brain stimulation (i.e., TMS and tDCS) in conditions characterized by deficits in fear extinction, abnormal decision-making processes, impulsivity, and compulsive behaviors.

He received a Frontier Fund award, an International Obsessive-Compulsive Foundation Award, the Irving Institute for Clinical and Translational Research award at Columbia, and a NIH R21 to support his work with TMS to the pre-supplementary motor area (SMA) in the treatment of Obsessive-Compulsive Disorder (OCD). He published the original finding that 1 Hz rTMS to the pre-SMA was helpful in treating patients with OCD. He also published findings of clinical efficacy of rTMS in Tourette’s Syndrome, and findings of antidepressant and anti-panic activity of right prefrontal 1 Hz TMS. He received a Frontier Fund award and the NYSPI pilot award in the MRI research program at Columbia to support his work with TMS to the Temporo-Parietal Junction (TPJ) in the treatment of Depersonalization Derealization Disorder (DPRD).

Dr. Mantovani served as Principal Investigator on a NARSAD Young Investigator Award (TMS in the treatment of Panic Disorder with comorbid Major Depression), and was co-principal investigator on R21 MH082323-01 (TMS for individuals with severe Tourette’s Syndrome). He recently completed as Principal Investigator an R21 MH091276-01 on TMS for treatment of Obsessive-Compulsive Disorder and as co-principal investigator an R21 CA178813 on Enhancing relapse prevention for smoking cessation with TMS. Dr. Mantovani was selected and received the CUNY Scholar Incentive Award in 2017 and is currently the principal investigator on two research studies: the first is a RCT of tDCS in OCD in collaboration with Dr. Bikson (director of the Neural Engineering Group at CCNY) and the second is an open-label study on the application of TMS in Cocaine Addiction in collaboration with Dr. Bonci (scientific director of the synaptic plasticity section at NIDA). 

Heading: 
Publications
Description: 

Original Articles:

  • Castrogiovanni P, Mantovani A, Soreca I, Cocchi M. Nutrition and brain: Strategic nourishment, oxidative stress and neuropsychiatric disorders. Italian Journal of Psychopathology, 2002; 8:335-348.

  • Mantovani A, Lombardelli A, Calossi S, Traverso S, Bossini L, Rossi S, Pieraccini F, Castrogiovanni P. Repetitive transcranial magnetic stimulation in post-traumatic stress disorder. Italian Journal of Psychopathology, 2003; 9:75-78.

  •  Rossi S, Ulivelli M, Bartalini S, Mantovani A, Castrogiovanni P, Passero S: Hypofunctioning of sensory gating mechanisms in patients with obsessive-compulsive disorder. Journal of Biological Psychiatry, 2005; 57:16-20.

  • Mantovani A, Lisanby SH, Pieraccini F, Castrogiovanni P, Ulivelli M, Rossi S: Repetitive Transcranial Magnetic Stimulation (rTMS) in the treatment of obsessive-compulsive disorder and tourette’s syndrome. International Journal of Neuropsychopharmacology, 2006; 9: 95-100.

  • Mantovani A, Lisanby SH, Pieraccini F, Castrogiovanni P, Ulivelli M, Rossi S: Repetitive Transcranial Magnetic Stimnulation (rTMS) in the treatment of panic disorder with comorbid major depression. Journal of Affective Disorders, 2007: 102:277-280.

  •  Mantovani A, Leckman JF, Grantz H, King RA, Sporn AL, Lisanby SH: Repetitive Transcranial Magnetic Stimulation of the Supplementary Motor Area in the treatment of Tourette Syndrome: Report of two cases. Clinical Neurophysiology, 2007; 118:2314-2315.

  • Fisher CE, Sporn AL, Mantovani A, Leckman JF, Lisanby SH: Electroconvulsive therapy as an alternative to Deep Brain Stimulation for medication-refractory Tourette Syndrome. Journal of ECT, 2008; 24:103-104.

  • Rossi S, De Capua A, Tavanti M, Calossi S, Polizzotto NR, Mantovani A, Falzarano V, Bossini L, Passero S, Bartalini S, Ulivelli M: Dysfunctions of cortical excitability in drug-naïve posttraumatic stress disorder patients. Biological Psychiatry, 2009; 66:54-61.

  • Mantovani A, Simpson HB, Fallon B, Rossi S, Lisanby S: Randomized sham-controlled trial of repetitive transcranial magnetic stimulation in treatment-resistant obsessive-compulsive disorder. International Journal of Neuropsychopharmacology, 2010; 13:217-27.

  • Mantovani A, Westin G, Hirsch J, Lisanby SH: Functional Magnetic Resonance Imaging guided Transcranial Magnetic Stimulation in Obsessive Compulsive Disorder. Biological Psychiatry, 2010; 67:e39-e40. 

  • Mantovani A, Simeon D, Urban N, Bulow P, Allart A, Lisanby SH: Temporo-Parietal Junction Stimulation in the treatment of Depersonalization Disorder. Psychiatry Research, 2011; 186:138-40.

  • Mantovani A, Kegeles LS, Simpson BH, Aly M, Allart A, Harrison A, Rossi S, Lisanby SH: Modulation of premotor GABAergic circuits in Obsessive-Compulsive Disorder (OCD) via Transcranial Magnetic Stimulation: evidence from magnetic resonance spectroscopy. Clinical Neurophysiology, 2011; 122, S181.

  • Mantovani A, Pavlikova M, Avery D, Nahas Z, McDonald WM, Wajdik CD, Holtzheimer PE, George MS, Sackeim HA, Lisanby SH: Long-term efficacy of Transcranial Magnetic Stimulation in Treatment Resistant Depression. Depression and Anxiety, 2012; 29:883-90.

  •  D’Urso G, Mantovani A, Barbarulo A, Labruna L, Muscettola G: Brain-Behavior relationship in a case of successful ECT for drug refractory catatonic OCD. Journal of ECT, 2012; 28:190-3.

  • Mantovani A, Aly M, Dagan Y, Allart A, Lisanby SH: Repetitive Transcranial Magnetic Stimulation in the treatment of Panic Disorder with comorbid Major Depression. Journal of Affective Disorders, 2013; 144:153-9.

  • D’Urso G, Mantovani A, Micillo M, Priori A, Muscettola G: Transcranial Direct Current Stimulation and Cognitive-Behavioral Therapy: Evidence of a Synergistic Effect in Treatment- Resistant Depression. Brain Stimulation, 2013; 6:465-7.

  • Mantovani A, Rossi S, Bassi DB, Simpson HB, Fallon BA, Lisanby SH: Modulation of motor cortex excitability in obsessive-compulsive disorder: an exploratory study on the relations of neurophysiology measures with clinical outcome. Psychiatry Research, 2013; 210:1026-32.

  • Mantovani A, Shubeck J, Gowatsky J, Simpson HB, Greenberg B: Incompleteness and harm avoidance in obsessive compulsive disorder: Different response to transcranial magnetic stimulation. Clinical Neurophysiology, 2013; 124:e182-e183.

  • Christopeit M, Simeon D, Urban N, Gowatsky J, Lisanby SH, Mantovani A: Effect of repetitive Transcranial Magnetic Stimulation (rTMS) on specific symptoms clusters in depersonalization disorder (DPD). Brain Stimulation, 2014; 7:141-3.

  • Landeros-Weisenberger A, Mantovani A, Motlagh M, de Alvarenga PG, Katsovich L, Leckman JF, Lisanby SH: Randomized sham controlled double-blind trial of repetitive Transcranial Magnetic Stimulation for adults with severe Tourette Syndrome. Brain Stimulation, 2015; 8:574-81. Co-First Author

  • Tortella G, Casati R, Aparicio LM, Mantovani A, Senco NM, D’Urso G, Brunelin J, Guarienti F, Selingardi P, Muskat D, Sampaio B, Valiengo L, Moffa A, Simis M, Borrione L, Brunoni AR: Transcranial Direct Current Stimulation in Psychiatric Disorders. World Journal of Psychiatry, 2015; 5:88-102.

  •  D’Urso G, Brunoni AR, Anastasia A, Micillo M, De Bartolomeis A, Mantovani A: Polarity- dependent effects of Transcranial Direct Current Stimulation in Obsessive Compulsive Disorder. Neurocase, 2015; 14:1-5.

  •  Senco NM, Huang Y, D’Urso G, Parra LC, Bikson M, Mantovani A, Shavitt RG, Hoexter MQ, Miguel EC, Brunoni AR: Transcranial Direct Current Stimulation (tDCS) in Obsessive Compulsive Disorder: a review of emerging clinical evidence and consideration for optimal montage of electrodes. Expert Review of Medical Devices, 2015; 12:381-91.

  • Pedapati EV, Di Francesco M, Wu S, Giovanetti C, Nash T, Mantovani A, Ammerman R, Harris E: Neural Correlates Associated with Symptoms Provocation in Pediatric Obsessive Compulsive Disorder after a Single Session of Sham-Controlled Repetitive Transcranial Magnetic Stimulation. Psychiatry Research, 2015; 233:466-73.

  •  D’Urso G, Brunoni AR, Bruzzese D, De Bartolomeis A, Mantovani A: Cathodal vs Anodal Transcranial Direct Current Stimulation to the pre-Supplementary Motor Area for the treatment of Obsessive-Compulsive Disorder. Depression and Anxiety, 2016; 33:1132-40.

  • Sheffer CE, Bickel WK, Brandon TH, Franck CT, Deen D, Panissidi L, Abdali SA, Pittman JC, Lunden SE, Prashad N, Malhotra R, Mantovani A: Preventing relapse to smoking with transcranial magnetic stimulation: Feasibility and potential efficacy. Drug and Alcohol Dependence, 2018; 182:8-18.

  • Bikson M, Brunoni AR, Charvet LE, Clark V, Cohen L, Deng ZD, Dmochowski J, Edwards D, Frohlich F, Kappenman E, McMullen D, Lim KO, Loo C, Mantovani A, Parra LC, Pearson M, Richardson JD, Sehatpour P, Sommers D, Unal G, Wassermann EM, Woods AJ. Rigor and Reproducibility in Research with Transcranial Electrical Stimulation:  An NIMH-Sponsored Workshop. Brain Stimulation, in press.

  • Sauvaget A, Poulet E, Mantovani A, Bulteau S, Moutaud B, Patemoster M, De Bartolomeis A, D’urso G: Designing a Neuromodulation Unit in Psychiatry: Do it Yourself. Journal of ECT, in press.

 

Chapters and books:

  • Mantovani A, Goldman M. (2006) Depression and somatic treatments, in Schwartz TL, Peterson TJ (eds): Depression: Treatment Strategies and Management. Taylor & Francis Books.

  • Mantovani A, Lisanby SH. (2007) TMS in major depression, in George MS, Belmaker RH (eds):Transcranial Magnetic Stimulation in Clinical Psychiatry. Washington, D.C.: American Psychiatric Publishing Inc.

  • Mantovani A, Bulow PM, Stanford A, Lisanby SH. (2008) Focal brain stimulation approaches to psychiatric treatment: Transcranial Magnetic Stimulation (TMS), Magnetic Seizure Therapy (MST), Vagus Nerve Stimulation (VNS), Deep Brain Stimulation (DBS), and Transcranial Direct Current Stimulation (tDCS), in Tyrer P, Silk K (eds): Cambridge textbook of effective treatments in psychiatry. Cambridge: Cambridge Press.

  • Mantovani A, Lisanby SH. (2010) Brain Stimulation in the Treatment of Anxiety Disorders, in Simpson HB, Neria Y, Lewis-Fernadez R, Schneier F (eds): Understanding Anxiety: Clinical and research perspectives from the Columbia University Department of Psychiatry. Cambridge: Cambridge Press.

  •  D’Urso G, Sassi T, De Bartolomeis A, Mantovani A. (2016) OCD, Anxiety Disorders and PTSD, in Brunoni AR, Nitsche M, Loo C (eds): Transcranial Direct Current Stimulation in Neuropsychiatric Disorders: Clinical Principles and Management. Springer International Publishers.

Heading: 
Reviews
Description: 
  • Mantovani A, Lisanby SH: Applications of TMS to therapy in psychiatry. Psychiatric Times, 2004; Vol. XXI (9):56-72.

  • Mantovani A: TMS and Anxiety Disorders. MAGNET, Fall Issue 2013; http://www.clinicaltmssociety.org/newsletter/fall2013/

  • D’Urso G, Lattanzio S, Sassi T, Mantovani A. La neuromodulazione nel trattamento delle forme farmacoresistenti di depressione, disturbo bipolare e schizofrenia. NOOS, 2016; Vol. 22 (1):35-52.

 

 

<< Back To Directory