Professor
Deputy Chair
Education
B.S.E., Biomedical Engineering, Tulane University, 1988
[University of Leeds, UK, Tulane Junior Year Abroad Honors Program 1986-87]
Ph.D., Biomedical Engineering, Tulane University, 1994
Postdoc, Musculo-Skeletal Research Laboratory, SUNY Stony Brook, 1994-96
Research Interests
Understanding the adaptive response of bone to altered mechanical loading, including bone's mechanosensory system; investigating interstitial fluid flow in bone as a possible mechanism of mechanical signal transduction; quantifying the effects of estrogen deficiency and immobilization on the osteocyte microenvironment; using mechanical loading to enhance drug transport to bone tumors.
Recent & Frequently Cited Publications
Ciani, C., Sharma, D., Doty, S.B. and Fritton, S.P., “Ovariectomy Enhances Mechanical Load-Induced Solute Transport around Osteocytes in Rat Cancellous Bone,” Bone 59:229-34, 2014.
Palacio-Mancheno, P.E., Larriera, A.I., Doty, S.B., Cardoso, L. and Fritton, S.P., “3D Assessment of Cortical Bone Porosity and Tissue Mineral Density Using High-Resolution Micro-CT: Effects of Resolution and Threshold Method,” Journal of Bone and Mineral Research, 29(1):142-50, 2014.
Benalla M., Palacio-Mancheno, P.E., Fritton S.P., Cardoso L., and Cowin S.C., “Dynamic Permeability of the Lacunar-Canalicular System in Human Cortical Bone,” Biomechanics and Modeling in Mechanobiology,13(4):801-12, 2014.
Cardoso L., Fritton S.P., Gailani G., Benalla M., and Cowin S.C., “Advances in Assessment of Bone Porosity, Permeability and Interstitial Fluid Flow,” Journal of Biomechanics, 46(2):253-65, 2013.
Sharma, D., Ciani, C., Ramirez Marin, P.A., Levy, J.D., Doty, S.B. and Fritton, S.P., “Alterations in the Osteocyte Lacunar-Canalicular Microenvironment due to Estrogen Deficiency,” 51(3):488-97, 2012.
Fritton, S.P. and Weinbaum, S., “Fluid and Solute Transport in Bone: Flow-Induced Mechanotransduction,” Annual Review of Fluid Mechanics, 41:347-374, 2009.
Ciani, C., Doty, S.B. and Fritton, S.P., “An Effective Histological Staining Process to Visualize Bone Interstitial Fluid Space Using Confocal Microscopy,” Bone, 44:1015-1017, 2009.
Beno, T., Yoon, Y.-J., Cowin, S.C. and Fritton, S.P., “Estimation of Bone Permeability Using Accurate Microstructural Measurements,” Journal of Biomechanics, 39(13):2378-87, 2006.
Ciani, C., Doty, S.B., and Fritton, S.P., “Mapping Bone Interstitial Fluid Movement: Displacement of Ferritin Tracer During Histological Processing,” Bone, 37(3):379-87, 2005.
Mi, L.Y., Fritton, S.P., Basu, M., and Cowin, S.C., “Analysis of Avian Bone Response to Mechanical Loading, Part One: Distribution of Bone Fluid Shear Stress Induced by Bending and Axial Loading,” Biomechanics and Modeling in Mechanobiology, 4(2-3):118-131, 2005.
Mi, L.Y., Basu, M., Fritton, S.P. and Cowin, S.C., “Analysis of Avian Bone Response to Mechanical Loading, Part Two: Development of a Computational Connected Cellular Network to Study Bone Intercellular Communication,” Biomechanics and Modeling in Mechanobiology, 4(2-3):132-146, 2005.
Wang, L., Ciani, C., Doty, S.B., and Fritton, S.P., “Delineating Bone’s Interstitial Fluid Pathway In Vivo,” Bone, 34(3):499-509, 2004.
Wang, L., Fritton, S.P., Weinbaum, S. and Cowin, S.C., “On Bone Adaptation due to Venous Stasis,” Journal of Biomechanics, 36(10):1439-1451, 2003.
Fritton, S.P. and Rubin, C.T., "In Vivo Measurement of Bone Deformations Using Strain Gages,” Chapter 8 in Bone Mechanics Handbook , Cowin, S.C. (Ed.), CRC Press, p. 8.1-8.41, 2001.
Wang, L., Cowin, S.C., Weinbaum, S. and Fritton, S.P., "Modeling Tracer Transport in an Osteon Under Cyclic Loading," Annals of Biomedical Engineering , 28(10):1200-1209, 2000.
Fritton, S.P., McLeod, K.J. and Rubin, C.T., "Quantifying the Strain History of Bone: Spatial Uniformity and Self-similarity of Low Magnitude Strains," Journal of Biomechanics , 33(3):317-325, 2000.
Recent Funding
Harvey L. Karp Discovery Award in the Sciences 2015-16
NSF: Effects of Reduced Mechanical Loading on Bone Microarchitecture and Cell Function 2014-17
PSC-CUNY: Assessment of Bone Microstructural Changes in an Osteoporosis Model 2011-14
NIH (NIAMS): Role of Fluid Flow in Bone's Response to Mechanical Loading 2006-11
CCNY-MSKCC Biomedical Engineering Partnership: Enhancement of Cancer Drug Delivery to Bone Tumors using Non-invasive Mechanical Loading 2007-09
Courses Taught
BME 101 Introduction to Biomedical Engineering (1 credit)
BME 220 Biostatistics and Research Methods (3 credits)
ME 246 Engineering Mechanics I (3 credits)
ME 330 Mechanics of Materials (3 credits)
BME 501 Cell and Tissue Mechanics (3 credits)
BME 503 Cell and Tissue - Biomaterial Interactions (3 credits)
BME I0000 Biomedical Engineering Seminar (0 credits, graduate-level)
BME I7300 Cell and Tissue - Biomaterial Interactions (3 credits, graduate-level)
BME I9300 Scientific Ethics (1 credit, graduate-level)
Last Updated: 09/19/2016 16:34