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Eitan Friedman

Faculty and Staff Profiles

Eitan Friedman

Medical Professor

Harris Hall 203
Phone Number: 

Ph.D  1997 New York Medical College

B.A.,1966, Brooklyn College

Research Interests

Transmembrane signaling via G protein-coupled receptors and plasticity of these receptors in health and disease.

Role of MAP kinases in GPCR signaling.

Role of altered cellular signal transduction in the etiology of bipolar illness and in the mechanism of action of mood stabilizers.

Characterization of a novel brain dopamine receptor that couples to phospholipase C.

Molecular mechanisms involved in mediating the morphological and behavioral effects of in utero exposure to cocaine. 


T. Inagaki, M. Frankfurt, E. Friedman, V. Luine: Bisphenol Alters estrogen-induced memory enhancement: alterations in spine density and monoamines in rat brain, (in press).       

Banerjee S.P, Ragnauth, A., Chan, C.Y, Agovic, M.S, Sostris, V., Jashanmal, I., Vidal, L. and Friedman, E. Neuropsychopharmacological Actions of Taurine in Taurine and its Actions on the Nervous System. Volume 1, Taurine 8: The Nervous System, Immune System, Diabetes and the Cardiovascular System. Springer, New York. Chapter 1. Pp.3-18., 2013.   

Chan, C.Y., Sun H.S., Shah, S.M., Agovic, M.S. , Ho, I, Banerjee S.P. and Friedman, E. Direct Interaction of Taurine with The NMDA Glutamate Receptor Sub-Type Via Multiple Mechanisms in Taurine and its Actions on the Nervous System. Volume 1, Taurine 8: The Nervous System, Immune System, Diabetes and the Cardiovascular System. Springer, New York. Chapter 4. pp. 45-52., 2013

M. Frankfurt, K. Y. Salas-Ramirez*, E. Friedman and V. N. Luine. Cocaine alters dendritic spine density in cortical and subcortical brain regions of the postpartum and virgin female rat. Synapse. 65(9): 955-61, 2011.

HY Wang, D. Crupi, J Liu, A Stucky, G Cruciata, A DiRocco, E Friedman, A Quartarone, MF Ghilardi. Repetitive trans-cranial magnetic stimulation enhances BDNF-TrkB signaling in both brain and lymphocyte. J Neuroscience. 31(30):11044 – 11054, 2011.

KY Salas-Ramirez, M Frankfurt, A Alexander, VN Luine, E Friedman. Prenatal cocaine exposure increases anxiety, impairs cognitive function and increases dendritic spine density in adult rats: Influence of sex. Neuroscience. 169: 1287-95, 2010

T. Inagaki, M. Frankfurt, E. Friedman, V. Luine: Bisphenol Alters estrogen-induced memory enhancement: alterations in spine density and monoamines in rat brain, (in press) 

R. Crupi, M. Cambiaghi, L. Spatz, R. Hen, M. Thorn, E. Friedman, G. Vita, F. Battaglia: Reduced adult neurogenesis and altered emotional behaviors in autoimmune-prone BAFF transgenic mice, Biol. Psych. 67:558-566, 2010. 

E. Yablonsky-Alter, M.S. Agovic, E. Gashi, T.I. Lidsky, S.P. Banerjee, E. Friedman: Cocaine challenge enhances release of neuroprotective amino acid taurine in the chronic cocaine treated rats. Brain Research Bull. 79(3-4):215-8, 2009.    

K. Bakshi, S. Gennaro, C.Y. Chan, M. Kosciuk, J. Liu, A. Stucky, E. Trenkner, E. Friedman, R.G. Nagele, H.Y. Wang: Prenatal cocaine reduces AMPA receptor synaptic expression through hyperphosphorylation of the synaptic anchoring protein GRIP. J. Neurosci. 29:6308-6317, 2009.  

X. Zhen, P. Sun, J. Wang, W. Gu, W. Cheng, G. Jin, E. Friedman and J.Zheng: PSD-95 Regulates D1 Dopamine Receptor Resensitization but not Receptor-mediated Gs-protein Activation. Cell Research 19:612-624, 2009.  

M. Frankfurt, H.Y. Wang, N. Marmolejo, K. Bakshi, E. Friedman: Prenatal cocaine increases dendritic spine density in the medical prefrontal cortex, hippocampus and striatum of the rat. Developmental Neurosci. 31:71-75,2009.

F. Battaglia, H.Y. Wang, M. Felice Ghilardi, E. Gashi, A. Quartarone, E. Friedman and R. A. Nixon: Cortical Plasticity in Alzheimer's Disease in Humans and Rodents. Biol. Psych. 62:1405-1412, 2007.

H.Y. Wang, E. Friedman, M.C. Olmstead, and L.H. Burns: Ultra-low-dose naloxone suppresses opioid tolerance, dependence and associated changes in MU opioid receptor-g protein coupling and Gβγ signaling. Neuroscience 135:247-261, 2005.

X. Zhen, S. Goswami, S. A. Amir, M. Gil, and E. Friedman:The role of the phosphatidylinositol linked D1 dopamine receptor in the pharmacology of SKF83959. Pharmacol. Biochem. Beh. 80:597-601, 2005. 

A. Schmidt, Azriel, Vogel, R., Rutledge, S.J., Opas, E.E., Rodan, G.A., and Friedman, E. Cross talk between an activator of nuclear receptors-mediated transcription and the D1 dopamine receptor signaling pathway. Pharmacol Biochem. Beh. 80:379-385, 2005.   

C.G. Hahn, G. Gomez, N. Rawson, D. Restrepo, E. Friedman, R. Josiason, E.A. Pribitkin, L.D. Lowry, R.J. Gallop and N.E. Rawson: Aberrant intracellular calcium signaling in olfactory neurons from bipolar patients. Am. J. Psy. 162:616-618, 2005.     

C.G. Hahn, Umapathy, H.Y. Wang, R. Koneru, D.F. Levinson and E. Friedman: Lithium and valproic acid treatments reduce PKC activation and receptor-G protein coupling in platelets of bipolar manic patients. J. Psychiatric. Res. 39:355-363, 2005.    

X.Zhen, S.Goswami, S.A. Abdali, M. Gil, K. Bakshi and E. Friedman: Regulation of Cyclin-Dependent Kinase 5 and Calcium/Calmodulin-Dependent Protein Kinase II by Phosphatidylinositol-Linked Dopamine Receptor in Rat Brain. Mol. Pharm. 66:1500-1507, 2004.      

H.Y. Wang and E. Friedman: Aberrant serotonin receptor-mediated activation of G proteins in postmortem brains from Alzheimer's disease patients. Mid Taiwan J. Med. 9, 1-10, 2004.      

M. Gil, X. Zhen and E. Friedman. Prenatal cocaine exposure alters glycogen synthase kinase-3ß (GSK3ß) pathway in select rabbit brain areas. Neurosci. Letters. 349:143-146, 2003.   

L.Q. Zhen, S. Goswami, G. Cai, X. Zhen and E. Friedman: SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain. J. Neurochem. 85, 378-386, 2003.     

X. Zhen, C. Torres, and E. Friedman: Lithium regulates protein tyrosine phosphatase in vitro and in vivo. Psycopharmacol.2002.   

G. Cai, H. Y. Wang, and E. Friedman: Increased dopamine receptor signaling and dopamine receptor-G protein coupling in denervated striatum. J. Pharmacol. Exper. Ther.302:1105-1112, 2002.     

H.Y. Wang and E. Friedman: Increased association of brain protein kinase C with RACK1 in bipolar affective disorder: implication for enhanced protein kinase C activation. Biol. Psych. 50:364-370, 2001.       

X. Zhen, C. Torres, H.Y. Wang, E. Friedman. Prenatal exposure to cocaine disrupts D1A dopamine receptor function via selective inhibition of protein phosphatase 1 pathway in rabbit frontal cortex. J Neurosci. 21, 9160-9167, 2001.       

X. Zhen, J. Zhang, G.P. Johnson, E. Friedman: D4 dopamine receptor differentially regulates Akt/NF-κB and ERK pathway in D4MN9D cells. Mol. Pharmacol 60, 857-864,2001.  

H.Y. Wang, G. P. Johnson, E. Friedman: Chronic lithium treatment inhibits protein kinase C translocation in rat brain cortex. Psychoparmacol. 158, 80-86, 2001.       

L.Q. Jin, H.Y. Wang and E. Friedman : Stimulated D1 dopamine receptors couple to multiple Gα proteins in different brain regions. J. Neurochem. 78, 1-11, 2001.

T.M . Seasholtz, G. Cai, H.Y. Wang, and E. Friedman: Effects of ischemia-reperfusion on vascular contractility and α1 adrenergic receptor signaling in the rat tail. J. Appl. Physiol. 91:1004-1010, 2001.      

X. Zhen, W. Du, A. G. Romano, E. Friedman, and J.A. Harvey: The p38 Mitogen-activated protein kinase is involved in associative learning in rabbits J. Neurosci. 21:5513-5519, 2001.       

A. Harvey, A. G. Romano, M. Gabriel, K. J. Simansky, W. Du, V.J.Aloyo, and E. Friedman: Effects of prenatal exposure to cocaine on the developing brain: anatomical, chemical, physiological and behavioral consequences. Neurotoxicol. Res. 3:117-143, 2001.      

N.Tilakaratne, G. Cai, and E. Friedman: Attenuation of cocaine-induced genomic and functional responses in prenatal cocaine-exposed rabbits. Pharmcol. Biochem.& Behavior 69:225-232, 2001.  

L. B. Jones, D. Stanwood, B. S. Reinoso, R. A. Washington, H.Y. Wang, E. Friedman, and P. Levitt: In utero cocaine-induced dysfunction of dopamine D1 receptor signaling and abnormal differentiation of cerebral cortical neurons. J Neursci. 20:4606-4614, 2000.   

A. Can, K. Sayar, E. Friedman, C. Ambrosio, E. Erdemli, and H. Gurdal: The effect of agonist stimulation and b2-adrenergic receptor level on cellular distribution of Gsa protein. Cell. Signal. 12:303-309, 2000. 

F. Gao, T. A. Christopher, B.L. Lopez, X. L. Ma, G. Cai, and E. Friedman: Mechanism of decreased adenosine protection in reperfusion injury of aging rats. Am. J Physiol. 279:H329-H338.       

H.Y. Wang, T.R. Bashore, and E. Friedman: Age-related decreases in lymphocyte protein kinase C and translocation are reduced by aerobic fitness. J Gerontol. 55A, B545-B551, 2000.    

G. Cai, X. Zhen, K. Uryu, and E. Friedman: Activation of extracellular signal-regulated protein kinases is associated with a sensitized locomotor response to D2 dopamine receptor stimulation in unilateral 6-hydroxydopamine-lesioned rats. J Neurosci. 20:1849-1857, 2000.

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