Medical Professor and Chair
Molecular, Cellular and Biomedical Sciences
Ph.D 1997 New York Medical College
B.A.,1966, Brooklyn College
Transmembrane signaling via G protein-coupled receptors and plasticity of these receptors in health and disease.
Role of MAP kinases in GPCR signaling.
Role of altered cellular signal transduction in the etiology of bipolar illness and in the mechanism of action of mood stabilizers.
Characterization of a novel brain dopamine receptor that couples to phospholipase C.
Molecular mechanisms involved in mediating the morphological and behavioral effects of in utero exposure to cocaine.
Guo L, Chen Y, Zhao R, Wang G, Friedman E, Zhang A, and Zhen X. Allosteric modulation of sigman-1 receptors elicits anti-seizure activities. Br J pharmacol. 2015 Aug;l 72(16):4052-65
Fontanesi C, Kvint S, Frazzitta G, Bera R, Ferrazzoli D, Di Rocco A, Rebholz H, Friedman E, Pezzoli G, Quartarone A, Wang HY, and Ghilardi MF. Intensive rehabilitation enhances lymphocyte BDNF-TrkB
signaling in patients with parkinson's disease. Neurorehabil Neural repair. 2015 Aug 7
Carmona, N.M, Frankfurt, M, and Friedman, E. Effects of Cocaine and Estrogen on BDNF-Trk B Signaling in hippocampi of ovariectomized rats. Applied Science, 2, 2016 Jan
Castello, J., Ragnauth, A., Friedman, E. and Rebholz, H. CK2-An Emerging Target for Neurological and Psychiatric Disorders. Pharmaceuticals 2017
Cortes M., Malave L., Castello J., Flajolet M., Cenci M. A., Friedman E. and Rebholz H. Ck2oppositely modulates L-DOPA induced dyskinesia via striatal projection neurons expressing Dl- or 02-receptors. Journal of Neuroscience 37 (49} 11930-11946, 2017
Castello J.,Le Francois B., Fajolet M., Greengard P., Friedman, E., and Rebholz H. CK2 regulates 5-HT4 receptor signaling and modulates depressive-like behavior. Molecular Psychiatry 10, 1038- 2017
Le Franois, B, Zhang, L, Mahajan, G.J., Stockmeier, C.A., Friedman, E and Albert. P.R. Alternative splicing of the human 5-HT1A mRNA 3'- UTR enhances its stability and is impaired in Major depression (submitted)
Chan, Y.C , , Singh I., Lee E.J., Olufawo M., ,Magnuson H., Zohaib M., Anazco-Ayala A., Pabla A., Friedman E.,. Banerjee S.P. Operational Characteristics of Inhibition of Electricall Evoked Potentials in Rat Medial Prefrontal Cortical Slices by Ro25-6981 and TCN-213 and Their Respective Modulation by Coapplied Taurine (Submitted)
Bakshi K., Parihar R., Goswami SK, Walsh M, Friedman E, Wang Hy. Prenatal cocaine exposure uncouplesmGluR1 from Homer1 and Gq Protenins. pLoS One. 2014
Chan, C.Y., Sun, H.s, Shah, S.M., Agovic, M.S., Friedma, E., Banerjee, S.P. Modes of direct modulation by taurine of the glutamate NMDA receptor in the rat cortex. Eur J Pharmacology. 2014 April 2015; 728:167-175
Mu Y, Ren Z., Jia J, Gao B., x. Inhibition of phosphodiesterase 10A attenuated morphine-induced conitioned place preference: Mol Brain, 2104 Sep 25; 7:70
Chan ,CY, Singh, I, Magnuso H, Zohaib M, Bakshi KP, Le Francios B, Anazco-Ayala A, Lee EJ, Tom A, YeeMon K, Ragnauth A, Friedman E, and Banerjee SP. Taurine targets the GluN2b-Containig NMDA receptor Subtype. Adv. Exp. Med Biol. 2015; 803:531-44