We perform cardiovascular biomechanics research, integrating analytical, numerical and experimental approaches to investigate the role of calcified tissue on rupture of fibroatheromas. In additon, the lab performs research in bone quality, integrating musculoskeletal biomechanics, signal/image processing, bioinstrumentation and mechanotransduction in bone. Research in bone biomechanics includes studies of bone mineral density, microarchitecture and bone tissue quality at the microscopic and macroscopic levels. Experimental, theoretical and numerical approaches are combined for this purpose. Bone mechanical properties are evaluated from analysis of 3D images of cancellous bone, ultrasound wave propagation, mechanical tests and Finite Element Modeling. In particular, we are interested in assessing changes in the mechanical properties of cancellous bone after disuse with and without anti-resorptive therapy using ultrasound and 3D images from microCT scanning. Other studies include design of an ultrasound device for assessment of bone quality ex vivo and in vivo, theoretical investigations in poroelasticity and the interaction between wave propagation and porous media, and mechanotransduction of osteocytes using computational and animal models.