Serafin Piñol-Roma

Associate Medical Professor & Assistant Dean for Basic Science Curriculum


Harris Hall







Serafin Piñol-Roma


PhD 1990 Northwestern University

B.A., 1984, Hamilton College

Courses Taught

MED 20400 and MED 30500 - Molecules to Cells I and II - Course Director

Research Interests

Role of nuclear RNA-binding proteins and of RNA-protein complexes in metabolism and nucleocytoplasmic transport of RNA.

RNA-binding proteins in mitochondrial gene expression.

Myopathies and encephalomyopathies resulting from defects in mitochondrial gene expression.


Hoffmann, M.H., J. Tuncel, K. Skriner, M. Tohidast-Akrad, B. Türk, S. Piñol-Roma, G. Serre, G. Schett, R. Holmdahl, and G. Steiner. 2007. The rheumatoid arthritis-associated autoantigen hnRNP-A2 (RA33) is a major stimulator of autoimmunity in rats with pristane-induced arthritis. J. Immunol. 179:7568-7576.                       

Lykke-Andersen, S., S. Piñol-Roma, and J. Kjems. 2007. Alternative splicing of the ADAR1 transcript in a region that functions either as 5'-UTR or an ORF. RNA 13:1732-1744.                        

Hayer, S., M. Tohidast-Akrad, S. Haralambous, B. Jahn-Schmid, K. Skriner, S. Trembleau, H. Dumortier, S. Piñol-Roma, K. Redlich, G. Schett, S. Muller, G. Kollias, J. Smolen, and G Steiner. 2005. Aberrant expression of the autoantigen heterogeneous nuclear ribonucleoprotein-A2 (RA33) and spontaneous formation of rheumatoid arthritis-associated anti-RA33 autoantibodies in TNF-alpha transgenic mice. J Immunol. 15:8327-8336.                        

Mili, S., and S. Piñol-Roma. 2003. LRP130, a PPR motif protein with a non-canonical RNA-binding domain, binds in vivo to mitochondrial and nuclear RNA. Mol. Cell. Biol. 23:4972-4982.                        

Fritsch, R., D. Eselböck, K. Skriner, B. Jahn-Schmid, C. Scheinecker, B. Bohle, M. Tohidast-Akrad, S. Hayer, J. Neumüller, S. Piñol-Roma, J. S. Smolen, and G. Steiner. 2002. Characterization of autoreactive T cells to the autoantigens heterogeneous nuclear ribonucleoprotein A2 (RA33) and filaggrin in patients with rheumatoid arthritis. J. Immunol. 169:1068-1076.                        

Marcu, A., B. Bassit, R. Perez, and S. Piñol-Roma. 2001. Heterogeneous nuclear ribonucleoprotein complexes from Xenopus laevis oocytes and somatic cells. Int. J. Devel. Biol. 45:743-752.                        

Mili, S., H.J. Shu, Y. Zhao, and S. Piñol-Roma. 2001. Distinct RNP complexes of shuttling hnRNP proteins with pre-mRNA and mRNA: candidate intermediates in formation and export of mRNA. Mol. Cell. Biol. 21, 7307-7319.                        

Penkov, D., R. Ni, C. Else, S. Piñol-Roma, F. Ramirez, and S. Tanaka. 2000. Cloning of a human gene closely related to the genes coding for the c-myc single-stranded binding proteins. Gene 243:27-36.                        

Piñol-Roma, S. 1999. Association of non-ribosomal nucleolar proteins in ribonucleoprotein complexes during interphase and mitosis. Mol. Biol. Cell 10:77-90.