Susannah P. Fritton

Herbert G. Kayser Professor

Deputy Chair

Main Affiliation

Biomedical Engineering

Building

Steinman Hall

Office

ST-403E

Phone

212-650-5213

Fax

212-650-6727

Email

fritton@ccny.cuny.edu

Website

http://sfritton-lab.ccny.cuny.edu/

S Fritton

Susannah P. Fritton

Education

B.S.E., Biomedical Engineering, Tulane University, 1988

[University of Leeds, UK, Tulane Junior Year Abroad Honors Program 1986-87]

Ph.D., Biomedical Engineering, Tulane University, 1994

Postdoc, Musculo-Skeletal Research Laboratory, SUNY Stony Brook, 1994-96

Research Interests

Understanding the adaptive response of bone to altered mechanical loading, including bone's mechanosensory system;  investigating interstitial fluid flow in bone as a possible mechanism of mechanical signal transduction;  quantifying the effects of estrogen deficiency and disuse on the osteocyte microenvironment;  using mechanical loading to enhance drug transport to bone tumors.

Recent & Frequently Cited Publications

Gatti, V., Ghobryal, B., Gelbs, M.J., Gerber, M.B., Doty, S.B., Cardoso, L. and Fritton, S.P., “Botox-induced Muscle Paralysis Induces Alters Intracortical Porosity and Osteocyte Lacunar Density in Skeletally Mature Rats,” Journal of Orthopaedic Research, 37:1153-1163, 2019.
 
Sharma, D., Larriera, A.I., Palacio-Mancheno, P.E., Gatti, V., Fritton, J.C., Bromage, T.G., Cardoso, L., Doty, S.B. and Fritton, S.P., “The Effects of Estrogen Deficiency on Cortical Bone Microporosity and Mineralization,” Bone, 110:1-10, 2018.
 
Gatti, V., Azoulay, E.M. and Fritton, S.P., “Microstructural Changes Associated with Osteoporosis Negatively Affect Loading-induced Fluid Flow Around Osteocytes in Cortical Bone,” Journal of Biomechanics, 66:127-136, 2018.
 
Kaya, S., Basta-Pljakic, J., Seref-Ferlengez, Z., Majeska, R.J., Cardoso, L., Bromage, T., Zhang, Q., Flach, C.R., Mendelsohn, R., Yakar, S., Fritton, S.P., Schaffler, M.B., “Lactation-Induced Changes in the Volume of Osteocyte Lacunar-Canalicular Space Alter Mechanical Properties in Cortical Bone Tissue,” Journal of Bone and Mineral Research, 32:688-97, 2017.
 
Ciani, C., Sharma, D., Doty, S.B. and Fritton, S.P., “Ovariectomy Enhances Mechanical Load-Induced Solute Transport around Osteocytes in Rat Cancellous Bone,” Bone, 59:229-34, 2014.
 
Palacio-Mancheno, P.E., Larriera, A.I., Doty, S.B., Cardoso, L. and Fritton, S.P., “3D Assessment of Cortical Bone Porosity and Tissue Mineral Density Using High-Resolution Micro-CT: Effects of Resolution and Threshold Method,” Journal of Bone and Mineral Research, 29:142-50, 2014.
 
Benalla M., Palacio-Mancheno, P.E., Fritton S.P., Cardoso L., and Cowin S.C., “Dynamic Permeability of the Lacunar-Canalicular System in Human Cortical Bone,” Biomechanics and Modeling in Mechanobiology,13:801-12, 2014.
 
Cardoso L., Fritton S.P., Gailani G., Benalla M., and Cowin S.C., “Advances in Assessment of Bone Porosity, Permeability and Interstitial Fluid Flow,” Journal of Biomechanics, 46:253-65, 2013.
 
Sharma, D., Ciani, C., Ramirez Marin, P.A., Levy, J.D., Doty, S.B. and Fritton, S.P., “Alterations in the Osteocyte Lacunar-Canalicular Microenvironment due to Estrogen Deficiency,” Bone, 51:488-97, 2012.
 
Fritton, S.P. and Weinbaum, S., “Fluid and Solute Transport in Bone:  Flow-Induced Mechanotransduction,” Annual Review of Fluid Mechanics, 41:347-374, 2009.
 
Ciani, C., Doty, S.B. and Fritton, S.P., “An Effective Histological Staining Process to Visualize Bone Interstitial Fluid Space Using Confocal Microscopy,” Bone, 44:1015-1017, 2009.
 
Beno, T., Yoon, Y.-J., Cowin, S.C. and Fritton, S.P., “Estimation of Bone Permeability Using Accurate Microstructural Measurements,” Journal of Biomechanics, 39:2378-87, 2006.
 
Ciani, C., Doty, S.B., and Fritton, S.P., “Mapping Bone Interstitial Fluid Movement: Displacement of Ferritin Tracer During Histological Processing,” Bone, 37:379-87, 2005.
 
Mi, L.Y., Fritton, S.P., Basu, M., and Cowin, S.C., “Analysis of Avian Bone Response to Mechanical Loading, Part One: Distribution of Bone Fluid Shear Stress Induced by Bending and Axial Loading,” Biomechanics and Modeling in Mechanobiology, 4:118-131, 2005.
 
Mi, L.Y., Basu, M., Fritton, S.P. and Cowin, S.C., “Analysis of Avian Bone Response to Mechanical Loading, Part Two: Development of a Computational Connected Cellular Network to Study Bone Intercellular Communication,” Biomechanics and Modeling in Mechanobiology, 4:132-146, 2005.
 
Wang, L., Ciani, C., Doty, S.B., and Fritton, S.P., “Delineating Bone’s Interstitial Fluid Pathway In Vivo,” Bone, 34:499-509, 2004.
 
Wang, L., Fritton, S.P., Weinbaum, S. and Cowin, S.C., “On Bone Adaptation due to Venous Stasis,” Journal of Biomechanics, 36:1439-1451, 2003.
 
Fritton, S.P. and Rubin, C.T., "In Vivo Measurement of Bone Deformations Using Strain Gages,” Chapter 8 in Bone Mechanics Handbook , Cowin, S.C. (Ed.), CRC Press, p. 8.1-8.41, 2001.
 
Wang, L., Cowin, S.C., Weinbaum, S. and Fritton, S.P., "Modeling Tracer Transport in an Osteon Under Cyclic Loading," Annals of Biomedical Engineering, 28:1200-1209, 2000.  
 
Fritton, S.P., McLeod, K.J. and Rubin, C.T., "Quantifying the Strain History of Bone: Spatial Uniformity and Self-similarity of Low Magnitude Strains," Journal of Biomechanics, 33:317-325, 2000.

 

Recent Funding

NIH:  Development of Mechanical Interventions to Enhance Drug Delivery to Bone Tumors 2019-22  
 
PSC-CUNY:  Assessment of Muscle Changes after Botox Injection 2019-20
 
New York NASA Space Grant Consortium College and Fellowship Program, Cornell University (CCNY Affiliate Director) 2015-20
 
PSC-CUNY:  Evaluation of Bone Cell Attachment and Interconnectivity 2018-19
 
NSF:  Effects of Reduced Mechanical Loading on Bone Microarchitecture and Cell Function 2014-18
 
Harvey L. Karp Discovery Award in the Sciences 2015-16

Courses Taught

BME 101 Introduction to Biomedical Engineering (1 credit)  

BME 220 Biostatistics and Research Methods (3 credits)

ME 246 Engineering Mechanics I (3 credits)  

ME 330 Mechanics of Materials (3 credits)  

BME 501 Cell and Tissue Mechanics (3 credits) 

BME 503 Cell and Tissue - Biomaterial Interactions (3 credits)  

BME I0000 Biomedical Engineering Seminar (1 credit, graduate-level)  

BME I7300 Cell and Tissue - Biomaterial Interactions (3 credits, graduate-level)

BME I9300 Scientific Ethics:  Responsible Conduct of Research (1 credit, graduate-level)

Lab website

http://sfritton-lab.ccny.cuny.edu/