B.S.E., Biomedical Engineering, Tulane University, 1988

[University of Leeds, UK, Tulane Junior Year Abroad Honors Program 1986-87]

Ph.D., Biomedical Engineering, Tulane University, 1994

Postdoc, Musculo-Skeletal Research Laboratory, SUNY Stony Brook, 1994-96

Understanding the adaptive response of bone to altered mechanical loading, including bone's mechanosensory system;  investigating interstitial fluid flow in bone as a possible mechanism of mechanical signal transduction;  quantifying the effects of estrogen deficiency and disuse on the osteocyte microenvironment;  using mechanical loading to enhance drug transport to bone tumors.

Gatti, V., Gelbs, M.J., Guerra, R.B., Gerber, M.B. and Fritton, S.P., “Interstitial Fluid Velocity is Decreased around Cortical Bone Vascular Pores and Depends on Osteocyte Position in a Rat Model of Disuse Osteoporosis,” Biomechanics and Modeling in Mechanobiology, 20:1135-1146, 2021.

Gatti, V., Ghobryal, B., Gelbs, M.J., Gerber, M.B., Doty, S.B., Cardoso, L. and Fritton, S.P., “Botox-induced Muscle Paralysis Induces Alters Intracortical Porosity and Osteocyte Lacunar Density in Skeletally Mature Rats,” Journal of Orthopaedic Research, 37:1153-1163, 2019.

Sharma, D., Larriera, A.I., Palacio-Mancheno, P.E., Gatti, V., Fritton, J.C., Bromage, T.G., Cardoso, L., Doty, S.B. and Fritton, S.P., “The Effects of Estrogen Deficiency on Cortical Bone Microporosity and Mineralization,” Bone, 110:1-10, 2018.

Gatti, V., Azoulay, E.M. and Fritton, S.P., “Microstructural Changes Associated with Osteoporosis Negatively Affect Loading-induced Fluid Flow Around Osteocytes in Cortical Bone,” Journal of Biomechanics, 66:127-136, 2018.

Kaya, S., Basta-Pljakic, J., Seref-Ferlengez, Z., Majeska, R.J., Cardoso, L., Bromage, T., Zhang, Q., Flach, C.R., Mendelsohn, R., Yakar, S., Fritton, S.P., Schaffler, M.B., “Lactation-Induced Changes in the Volume of Osteocyte Lacunar-Canalicular Space Alter Mechanical Properties in Cortical Bone Tissue,” Journal of Bone and Mineral Research, 32:688-97, 2017.

Ciani, C., Sharma, D., Doty, S.B. and Fritton, S.P., “Ovariectomy Enhances Mechanical Load-Induced Solute Transport around Osteocytes in Rat Cancellous Bone,” Bone, 59:229-34, 2014.

Palacio-Mancheno, P.E., Larriera, A.I., Doty, S.B., Cardoso, L. and Fritton, S.P., “3D Assessment of Cortical Bone Porosity and Tissue Mineral Density Using High-Resolution Micro-CT: Effects of Resolution and Threshold Method,” Journal of Bone and Mineral Research, 29:142-50, 2014.

Benalla M., Palacio-Mancheno, P.E., Fritton S.P., Cardoso L., and Cowin S.C., “Dynamic Permeability of the Lacunar-Canalicular System in Human Cortical Bone,” Biomechanics and Modeling in Mechanobiology,13:801-12, 2014.

Cardoso L., Fritton S.P., Gailani G., Benalla M., and Cowin S.C., “Advances in Assessment of Bone Porosity, Permeability and Interstitial Fluid Flow,” Journal of Biomechanics, 46:253-65, 2013.

Sharma, D., Ciani, C., Ramirez Marin, P.A., Levy, J.D., Doty, S.B. and Fritton, S.P., “Alterations in the Osteocyte Lacunar-Canalicular Microenvironment due to Estrogen Deficiency,” Bone, 51:488-97, 2012.

Fritton, S.P. and Weinbaum, S., “Fluid and Solute Transport in Bone:  Flow-Induced Mechanotransduction,” Annual Review of Fluid Mechanics, 41:347-374, 2009.

Ciani, C., Doty, S.B. and Fritton, S.P., “An Effective Histological Staining Process to Visualize Bone Interstitial Fluid Space Using Confocal Microscopy,” Bone, 44:1015-1017, 2009.

Beno, T., Yoon, Y.-J., Cowin, S.C. and Fritton, S.P., “Estimation of Bone Permeability Using Accurate Microstructural Measurements,” Journal of Biomechanics, 39:2378-87, 2006.

Ciani, C., Doty, S.B., and Fritton, S.P., “Mapping Bone Interstitial Fluid Movement: Displacement of Ferritin Tracer During Histological Processing,” Bone, 37:379-87, 2005.

Mi, L.Y., Fritton, S.P., Basu, M., and Cowin, S.C., “Analysis of Avian Bone Response to Mechanical Loading, Part One: Distribution of Bone Fluid Shear Stress Induced by Bending and Axial Loading,” Biomechanics and Modeling in Mechanobiology, 4:118-131, 2005.

Mi, L.Y., Basu, M., Fritton, S.P. and Cowin, S.C., “Analysis of Avian Bone Response to Mechanical Loading, Part Two: Development of a Computational Connected Cellular Network to Study Bone Intercellular Communication,” Biomechanics and Modeling in Mechanobiology, 4:132-146, 2005.

Wang, L., Ciani, C., Doty, S.B., and Fritton, S.P., “Delineating Bone’s Interstitial Fluid Pathway In Vivo,” Bone, 34:499-509, 2004.

Wang, L., Fritton, S.P., Weinbaum, S. and Cowin, S.C., “On Bone Adaptation due to Venous Stasis,” Journal of Biomechanics, 36:1439-1451, 2003.

Fritton, S.P. and Rubin, C.T., "In Vivo Measurement of Bone Deformations Using Strain Gages,” Chapter 8 in Bone Mechanics Handbook , Cowin, S.C. (Ed.), CRC Press, p. 8.1-8.41, 2001.

Wang, L., Cowin, S.C., Weinbaum, S. and Fritton, S.P., "Modeling Tracer Transport in an Osteon Under Cyclic Loading," Annals of Biomedical Engineering, 28:1200-1209, 2000.  

Fritton, S.P., McLeod, K.J. and Rubin, C.T., "Quantifying the Strain History of Bone: Spatial Uniformity and Self-similarity of Low Magnitude Strains," Journal of Biomechanics, 33:317-325, 2000.

NIH:  Development of Mechanical Interventions to Enhance Drug Delivery to Bone Tumors 2019-23  

PSC-CUNY:  Assessment of Muscle Changes after Botox Injection 2019-22

New York NASA Space Grant Consortium College and Fellowship Program, Cornell University (CCNY Affiliate Director) 2015-24

PSC-CUNY:  Evaluation of Bone Cell Attachment and Interconnectivity 2018-19

NSF:  Effects of Reduced Mechanical Loading on Bone Microarchitecture and Cell Function 2014-18

Harvey L. Karp Discovery Award in the Sciences 2015-16

BME 220 Biostatistics and Research Methods (3 credits)

BME 501 Cell and Tissue Mechanics (3 credits) 

BME I9300 Scientific Ethics:  Responsible Conduct of Research (1 credit, graduate-level)

ENGR 300 Social, Economic and Cultural Impact of Biomedical Technology (3 credits)

BME 101 Introduction to Biomedical Engineering (1 credit)  

BME 503 Cell and Tissue - Biomaterial Interactions (3 credits)  

BME I7300 Cell and Tissue - Biomaterial Interactions (3 credits, graduate-level)

BME I0000 Biomedical Engineering Seminar (1 credit, graduate-level)  

ME 246 Engineering Mechanics I (3 credits)  

ME 330 Mechanics of Materials (3 credits)  

http://sfritton-lab.ccny.cuny.edu/