Cardiovascular Dynamics and Biomolecular Transport Laboratory

B.S., Chemical Engineering, 1969, Rutgers University 

M.S., Chemical Engineering, 1972, University of Delaware

Ph.D., Chemical Engineering, 1974, University of Delaware

Dr. Tarbell's current research interests fall into four basic areas: (1) effects of fluid mechanical forces on endothelial cells and smooth muscle cells, (2) in vitro studies of endothelial permeability, (3) mass transfer in the artery wall, and (4) cardiovascular fluid mechanics.

Google Scholar: https://scholar.google.com/citations?hl=en&user=B9dqT48AAAAJ

Selected Publications

Lopez-Quintero SV, Datta A, Amaya R, Elwassif M, Bikson M, Tarbell JM. DBS-relevant electric fields increase hydraulic conductivity of in vitro endothelial monolayers. J Neural Eng. 2010 Feb;7(1):16005. Epub 2010 Jan 14.

Cancel LM, Tarbell JM. The role of apoptosis in LDL transport through cultured endothelial cell monolayers. Atherosclerosis. 2010 Feb;208(2):335-341.Epub 2009 Aug 7.

Shi ZD, Ji XY,BerardiDE, Qazi H, Tarbell JM. Interstitial flow induces MMP-1 expression and vascular SMC migration in collagen I gels via an ERK1/2-dependent and c-Jun-mediated mechanism. Am J Physiol Heart Circ Physiol. 2010 Jan;298(1):H127-35. Epub 2009 Oct 30.

Shi ZD, Ji XY, Qazi H, Tarbell JM. Interstitial flow promotes vascular fibroblast, myofibroblast, and smooth muscle cell motility in 3-D collagen I viaupregulation of MMP-1. Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1225-34. Epub 2009 May 22.

Berardi, DE; Tarbell, JM. Stretch and shear interactions affect intercellular junction protein expression and turnover in endothelial cells. Cellular and Molecular Bioengineering. 2(3): 320-331, 2009.

Dabagh M, Jalali P, Tarbell JM. The transport of LDL across the deformable arterial wall: the effect of endothelial cell turnover and intimal deformation under hypertension. Am J Physiol Heart Circ Physiol. 2009 Sep;297(3):H983-96. Epub 2009 Jul 10.

Lopez-Quintero SV, Amaya R, Pahakis M, Tarbell JM. The endothelial glycocalyx mediates shear-induced changes in hydraulic conductivity. Am JPhysiol Heart Circ Physiol. 2009 May;296(5):H1451-6. Epub 2009 Mar 13.

Tarbell JM, Ebong EE. The endothelial glycocalyx: a mechano-sensor and -transducer. Sci Signal. 2008 Oct 7;1(40):pt8. Review.

Ebong, EE; Spray, DC; Tarbell, JM. The role of the endothelial glycocalyx layer in transducing fluid shear stress into intracellular signaling events. Biorheology, 45(1-2): 66-67, Published: 2008.

Phillips BE, Cancel L, Tarbell JM, Antonetti DA. Occludin independently regulates permeability under hydrostatic pressure and cell division in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2568-76. Epub 2008 Feb 8.

Tada S, Dong C, Tarbell JM. Effect of the stress phase angle on the strain energy density of the endothelial plasma membrane. Biophys J. 2007 Nov 1;93(9):3026-33.

Dancu MB, Berardi DE, Vanden Heuvel JP, Tarbell JM. Atherogenic Endothelial Cell eNOS and ET-1 Responses to Asynchronous Hemodynamics areMitigated by Conjugated Linoleic Acid. Ann Biomed Eng. 2007 Jul;35(7):1111-9.

Cancel LM, Fitting A, Tarbell JM. In Vitro Study of LDL Transport Under Pressurized (Convective) Conditions. Am J Physiol Heart Circ Physiol. 2007 Feb 23.

Garanich JS, Mathura RA, Shi ZD, Tarbell JM. Effects of fluid shear stress on adventitial fibroblast migration: implications for flow-mediated mechanisms of arterialization and intimal hyperplasia. Am J Physiol Heart Circ Physiol. 2007 Feb 16.

Weinbaum S, Tarbell JM, Damiano ER. The Structure and Function of the Endothelial Glycocalyx Layer. Annu Rev Biomed Eng. 2007 Mar 20.

Pahakis MY, Kosky JR, Dull RO, Tarbell JM.The role of endothelial glycocalyx components in mechanotransduction of fluid shear stress.BiochemBiophysResCommun. 2007 Mar 30;355(1):228-33.  

Tada S, Tarbell JM. Oxygen mass transport in a compliant carotid bifurcation model. Ann Biomed Eng. 2006 Sep;34(9):1389-99.

Dancu MB, Tarbell JM. Coronary endothelium expresses a pathologic gene pattern compared to aortic endothelium: Correlation of asynchronoushemodynamics and pathology in vivo. Atherosclerosis. 2006 Jun 23

Dancu MB, Tarbell JM. Large Negative Stress Phase Angle (SPA) attenuates nitric oxide production in bovine aortic endothelial cells. J Biomech Eng.2006 Jun;128(3):329-34.

Tarbell JM, Pahakis MY. Mechanotransduction and the glycocalyx. J Intern Med. 2006 Apr;259(4):339-50. Review. 

Garanich JS, Pahakis M, Tarbell JM. Shear stress inhibits smooth muscle cell migration via the nitric oxide-mediated downregulation of matrix metalloproteinase-2 activity. Am J Physiol Heart Circ Physiol. 2005 May;288(5):H2244-52.

Tarbell JM, Weinbaum S, Kamm RD. Cellular fluid mechanics and mechanotransduction. Ann Biomed Eng. 2005 Dec;33(12):1719-23. Review.

Tada S, Tarbell JM. A computational study of flow in a compliant carotid bifurcation-stress phase angle correlation with shear stress. Ann Biomed Eng. 2005 Sep;33(9):1202-12. 

Pang Z, Antonetti DA, Tarbell JM. Shear stress regulates HUVEC hydraulic conductivity by occludin phosphorylation. Ann Biomed Eng. 2005 Nov;33(11):1536-45.

Kim MH, Harris NR, Tarbell JM. Regulation of hydraulic conductivity in response to sustained changes in pressure. Am J Physiol Heart CircPhysiol. 2005 Aug 19.

Kim MH, Harris NR, Tarbell JM. Regulation of capillary hydraulic conductivity in response to an acute change in shear. Am J Physiol Heart Circ Physiol. 2005 Jul 1.

Ainslie KM, Garanich JS, Dull RO, Tarbell JM. Vascular smooth muscle cell glycocalyx influences shear stress-mediated contractile response. J ApplPhysiol. 2005 Jan;98(1):242-9.

Ainslie KM, Shi ZD, Garanich JS, Tarbell JM. Rat aortic smooth muscle cells contract in response to serum and its components in a calcium independent manner. Ann Biomed Eng. 2004 Dec;32(12):1667-75.

Tada S, Tarbell JM. Internal elastic lamina affects the distribution of macromolecules in the arterial wall: a computational study. Am J Physiol Heart CircPhysiol. 2004 Aug;287(2):H905-13.

Kim MH, Harris NR, Korzick DH, Tarbell JM. Control of the arteriolar myogenic response by transvascular fluid filtration.MicrovascRes.68(1):30-7. (2004)

Thi MM, Tarbell JM, Weinbaum S, SprayDC. The role of the glycocalyx in reorganization of the actin cytoskeleton under fluid shear stress: a "bumper-car" model. Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16483-8.

Dancu MB, Berardi DE, Vanden Heuvel JP, Tarbell JM. Asynchronous Shear Stress and Circumferential Strain Reduces Endothelial NO Synthase and Cyclooxygenase-2 but Induces Endothelin-1 Gene Expression in Endothelial Cells. Arterioscler Thromb Vasc Biol. 2004 Sep 2

DeMaio L, Antonetti DA, Scaduto RC Jr, Gardner TW, Tarbell JM. VEGF increases paracellular transport without altering the solvent-drag reflection coefficient. Microvasc Res. 2004 Nov;68(3):295-302. 

DeMaio L, Tarbell JM, Schwartz CJ, Gardner TW, Antonetti DA. A Transmural Pressure Gradient Induces Mechanical and Biological Adaptive Responses in Endothelial Cells. American Journal of Physiology: Heart and Circulatory Physiology. 2004;286:H731-H741.

Awards & Honors

Tau Beta Pi (1969), Phi Lambda Upsilon (1969), Sigma Xi (1979), National Research Service Award PHS (1983), Outstanding Teacher Award (College of Engineering 1987), Outstanding Research Award (College of Engineering 1988), Teacher of the Year (Department of Chemical Engineering, 1992), Editorial Boards: Journal of Biomechanical Engineering (1989-1995), Annals of Biomedical Engineering (1999-), Chairman of Biofluid Mechanics National Program Committee (ASME), 1989-1992, NIH Surgery and Bioengineering Study Section Member 1995-1999, Fellow of the American Institute of Medical and Biological Engineering (1996), Premier Research Award (College of Engineering, 1996), Distinguished Professor of Chemical Engineering and Bioengineering (PSU, 1998), AIMBE Board of Directors (1999), Fellow of the American Society of Mechanical Engineers (2001), President of the Biomedical Engineering Society (2002-2003), CUNY and Wallace Coulter Distinguished Professor of Biomedical Engineering (CCNY, 2003),  Lissner Award from the Bioengineering Division of ASME (2004), Fellow of the Biomedical Engineering Society (2005).