Luis Cardoso

Professor

Main Affiliation

Biomedical Engineering

Building

Steinman Hall

Office

ST-565

Phone

212.650.7154

Fax

212.650.6727

Email

cardoso@ccny.cuny.edu

Luis Cardoso

Education

Postdoc, Department of Orthopaedics, Mount Sinai School of Medicine, New York, NY 2004-2005  

Ph.D., Biomechanics, Paris University, France, 2003

MSc., Biomechanics, Paris University, France, 1999  

B.S., Biomedical Engineering, National Polytechnic Institute, Mexico City, Mexico, 1996

 

Research Interests

Research in bone quality, integrating musculoskeletal biomechanics, signal/images processing, bioinstrumentation and mechanotransduction in bone. Research in bone biomechanics includes studies of bone mineral density, microarchitecture and bone tissue quality at the microscopic and macroscopic levels. Experimental, theoretical and numerical approaches are combined for this purpose. Bone mechanical properties are evaluated from analysis of 3D images of cancellous bone, ultrasound wave propagation, mechanical tests and Finite Element Modeling. In particular, we are interested in assessing changes in the mechanical properties of cancellous bone after disuse with and without anti-resorptive therapy using ultrasound and 3D images from microCT scanning. Design of an Ultrasound device for assessment of bone quality ex vivo and in vivo. Theoretical studies in poroelasticity and the interaction between wave propagation and porous media Mechanotransduction of osteocytes in bone using animal models. We perform research on cardiovascular biomechanics, integrating analytical, numerical and experimental approaches to investigate the role of calcified tissue on rupture of fibroatheromas.

Publications

  • Paolis A De, Watanabe H, Nelson JT, Bikson  M, Packer  M, Cardoso L. “Human Cochlear Hydrodynamics: A High-Resolution μCT-Based Finite Element Study” Journal of Biomechanics. 2016 Nov; in press
  • Z He, DJ Leong, Z Zhuo, RJ Majeska, Cardoso L, Spray  DC, Goldring  MB, Cobelli NJ, Sun HB. “Strain-induced mechanotransduction through primary cilia, extracellular ATP, purinergic calcium signaling, and ERK1/2 transactivates CITED2 and downregulates MMP-1 and MMP-13 gene expression in chondrocytes” Osteoarthritis and Cartilage 24 (5), 892-901. 2016 May
  • Watanabe H, Cardoso L, Lalwani AK, Kysar JW. “A dual wedge microneedle for sampling of perilymph solution via round window membrane” Biomedical microdevices 18 (2), 1-8.  2016 April.
  • Crespo AM, Konda SR, Paolis A De, Cardoso L, KA Egol.” Posttraumatic Malalignment of the Humeral Shaft: Challenging the Existing Paradigm” Journal of orthopaedic trauma 30 (2), e48-e52.  2016 Feb.
  • Crespo AM, Konda SR, De Paolis A, Cardoso L, Egol KA. “Posttraumatic Malalignment of the Humeral Shaft: Challenging the Existing Paradigm” J Orthop Trauma. 30(2):e48-52. doi: 10.1097/BOT.0000000000000472. 2016 Feb
  • Maldonado N, Kelly-Arnold A, Laudier D, Weinbaum S, &  Cardoso L. "Imaging and analysis of microcalcifications and lipid/necrotic core calcification in fibrous cap atheroma" The international journal of cardiovascular imaging 31 (5), 1079-1087.
  • Haimovici M, Cardoso L. “Colapso do estoque de Umbrina canosai do Sul do Brasil devido à introdução do arrasto-de-meia-água” Boletim do Instituto de Pesca 42 (1), 258-267, 2016
  • Liu Z, Kennedy OD, Cardoso L, Basta-Pljakic J, Partridge NC, Schaffler MB, Rosen CJ, Yakar S” DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH” The FASEB Journal, 2016 Feb;30(2):635-52. doi: 10.1096/fj.15-275859. Epub 2015 Oct 19
  • Lobatto ME, Calcagno C, Millon A, Senders ML, Fay F, Robson PM, Ramachandran S, Binderup T, Paridaans MPM, Sensarn S, Rogalla S, Gordon RE, Cardoso L, Storm G, Metselaar JM, Contag CH, Stroes ESG, Fayad ZA, WJM Mulder "Atherosclerotic Plaque Targeting Mechanism of Long-Circulating Nanoparticles Established by Multimodal Imaging" ACS nano 9 (2), 1837-1847.
  • Cowin, SC & Cardoso L. "Blood and Interstitial flow in the hierarchical pore space architecture of bone tissue" J Biomech. 2015 Mar 18;48(5):842-54. doi: 10.1016/j.jbiomech.2014.12.013.
  • Cardoso L & Schaffler MB “Changes of elastic constants and anisotropy patterns in trabecular bone during disuse-induced bone loss assessed by poroelastic ultrasound”. J Biomech Eng. 2015 Jan;137(1). doi: 10.1115/1.4029179
  • Shi L, Palacio-Mancheno P, Badami J, Shin D, Zeng M, Cardoso L, Tu R, Fu BM. "Quantification of transient increase of the blood–brain barrier permeability to macromolecules by optimized focused ultrasound combined with microbubbles". Int J Nanomedicine. 2014 Sep 18;9:4437-48. doi: 10.2147/IJN.S68882. eCollection 2014.
  • Adise S, Saliu A, Maldonado N, Khatri V, Cardoso L, Rodríguez-Contreras A. "Effect of maternal care on hearing onset induced by developmental changes in the auditory periphery". J Neurosci. 2014 Mar 26;34(13):4528-33. doi: 10.1523/JNEUROSCI. 4188-13.2014.
  • Kennedy OD, Sun H, Wu Y, Courtland HW, Williams GA, Cardoso L, Basta-Pljakic J, Schaffler MB, Yakar S. Skeletal response of male mice to anabolic hormone therapy in the absence of the Igfals gene. Endocrinology. 2014 Mar;155(3):987-99. doi: 10.1210/en.2013-1819. Epub 2014 Jan 1.
  • Cardoso L, Kelly-Arnold A, Maldonado N, Laudier D, Weinbaum S. "Effect of tissue properties, shape and orientation of microcalcifications on vulnerable cap stability using different hyperelastic constitutive models". J Biomech. 2014 Mar 3;47(4):870-7. doi: 10.1016/j.jbiomech.2014.01.010. Epub 2014 Jan 13.
  • Leong DJ, Dragomir C, Goldring MB, Majeska RJ, Schaffler MB, Cardoso L, Hirsh D, Hardin JA, Cobelli NJ, Sun HB. The chondroprotective role of CITED2 in post-traumatic osteoarthritis 2013 Osteoarthritis and Cartilage, 21:304-305.
  • Benalla M, Palacio-Mancheno PE, Fritton SP, Cardoso L, Cowin SC. "Dynamic permeability of the lacunar-canalicular system in human cortical bone", Biomech Model Mechanobiol. 2014 Aug;13(4):801-12. doi: 10.1007/s10237-013-0535-7. Epub 2013 Oct 22.
  • Gong Z, Kennedy O, Sun H, Wu Y, Williams GA, Klein L, Cardoso L, Matheny RW Jr, Hubbard GB, Ikeno Y, Farrar RP, Schaffler MB, Adamo ML, Muzumdar RH, Yakar S. "Reductions in serum IGF-1 during aging impair health span" Aging Cell. 2014 Jun;13(3):408-18. doi: 10.1111/acel.12188. Epub 2013 Dec 30.
  • Leong DJ, Zhang H, Xu L, Tang J, Hirsh DM, Hardin JA, Cardoso L, Guha Ch, Cobelli NJ, and Hui B. Sun. "Therapeutic Ultrasound: Osteoarthritis Symptom-Modification and Potential for Disease Modification". J Surgery. 2013;1(2): 5.
  • Cardoso L and Weinbaum S, "Changing Views of the Biomechanics of Vulnerable Plaque Rupture, a Review" Ann Biomed Eng. 2014 Feb;42(2):415-31. doi: 10.1007/s10439-013-0855-x. Epub 2013 Jul 11.
  • Cowin SC & Cardoso L. "Difficulties arising from different definitions of tortuosity for wave propagation in saturated poroelastic media models". Z. Angew. Math. Mech., 1 – 11 (2013) / DOI 10.1002/zamm.201200086.
  • Palacio-Mancheno PE, Larriera AI, Cardoso L, Fritton SP. "3D assessment of cortical bone porosity and tissue mineral density using high-resolution micro-CT: Effects of resolution and threshold method". J Bone Miner Res. 2014 Jan;29(1):142-50 doi: 10.1002/jbmr.2012.
  • Kelly-Arnold A, Maldonado N, Laudier D, Aikawa E, Cardoso L, & Weinbaum S. "Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries", Proc Nat Acad Sci USA, 110(26):10741-10746; published ahead of print June 3, 2013, doi: 10.1073/pnas.1308814110 2013.
  • Wu Y, Sun H, Basta-Pljakic J, Cardoso L, Kennedy OD, Jasper H, Domené H, Karabatas L, Guida C, Schaffler MB, Rosen CJ, Yakar S. "Serum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone receptor". J Bone Miner Res. 2013 Jul;28(7):1575-86. doi: 10.1002/jbmr.1920.
  • Cardoso L, Fritton S, Benalla M, Gailani G, Cowin SC. "Advances in assessment of bone porosity, permeability and interstitial fluid flow" J Biomech. 2013 Jan 18;46(2):253-65. doi: 10.1016/j.jbiomech.2012.10.025. Epub 2012 Nov 19.
  • Souzanchi MF, Cardoso L, Cowin SC. "Tortuosity and the averaging of micro-velocity fields in poroelasticity", J Appl Mech. 2013 Mar;80(2):0209061-209065. Epub 2013 Feb 4.
  • Maldonado N, Kelly-Arnold A, Cardoso L, Weinbaum S. "The explosive growth of small voids in vulnerable cap rupture; cavitation and interfacial debonding". J Biomech. 2013 Jan 18;46(2):396-401. doi: 10.1016/j.jbiomech.2012.10.040. Epub 2012 Dec 6.
  • Souzanchi MF, Palacio Mancheno PE, Borisov YA, Cardoso L, Cowin SC. "Microarchitecture and bone quality in the human calcaneus: local variations of fabric anisotropy", J Bone Miner Res. 2012 Dec;27(12):2562-72. doi: 10.1002/jbmr.1710.
  • Moesen, M, Cardoso L, Stephen C. Cowin. "A symmetry invariant formulation of the relationship between the elasticity tensor and the fabric tensor." Mech Mater. 2012 Nov;54:70-83. Epub 2012 Jul 15.
  • Maldonado N, Kelly-Arnold A, Vengrenyuk Y, Laudier D, Fallon JT, Virmani R, Cardoso L, Weinbaum S. "A mechanistic analysis of the role of microcalcifications in atherosclerotic plaque stability: potential implications for plaque rupture". Am J Physiol Heart Circ Physiol. 2012 Sep 1;303(5):H619-28. doi: 10.1152/ajpheart.00036.2012. Epub 2012 Jul 9.
  • Gu XI, Palacio-Mancheno PE, Leong DJ, Williams E, Maldonado N, Li YH,  Laudier D, Majeska RJ,  Schaffler MB, Sun HB, Cardoso L. "High resolution micro arthrography of hard and soft tissues in a murine model". Osteoarthritis Cartilage. 2012 Sep;20(9):1011-9. doi: 10.1016/j.joca.2012.05.004. Epub 2012 May 18.
  • Rambhia SH, Liang X, Xenos M, Alemu Y, Maldonado N, Kelly A, Chakraborti S, Weinbaum S, Cardoso L, Einav S, Bluestein D. "Microcalcifications Increase Coronary Vulnerable Plaque Rupture Potential: A Patient-Based Micro-CT Fluid-Structure Interaction Study". Ann Biomed Eng. 2012 Jul;40(7):1443-54. doi: 10.1007/s10439-012-0511-x. Epub 2012 Jan 11.
  • Benalla M, Cardoso L, Cowin SC. "Analytical Basis for the Determination of the Lacunar-Canalicular Permeability of Bone Using Cyclic Loading", Biomech Model Mechanobiol. 2012 Jul;11(6):767-80. doi: 10.1007/s10237-011-0350-y. Epub 2011 Sep 30.
  • Cowin SC, Cardoso L. “Mixture theory-based poroelasticity as a model of interstitial tissue growth”, Mech Mater. 2012 Jan;44:47-57.doi:  10.1016/j.mechmat.2011.07.005.
  • Cardoso L, Cowin SC. "Role of the structural anisotropy of biological tissues on poroelastic wave propagation". Mech Mater. 2012 Jan;44:174-188.
  • Sun HB, Cardoso L, Yokota H. "Mechanical intervention for maintenance of cartilage and bone". Clin Med Insights Arthritis Musculoskelet Disord. 2011;4:65-70. doi: 10.4137/CMAMD.S6982. Epub 2011 Jun 29.
  • Elis S, Wu Y, Courtland HW, Cannata D, Sun HB, Beth-On M, Cardoso L, Rosen CJ and Yakar S. "Unbound (bioavailable) IGF-1 enhances somatic growth", Dis Model Mech. 2011 Sep;4(5):649-58. doi: 10.1242/dmm.006775. Epub 2011 May 31.
  • Cardoso L, Cowin SC. “Fabric dependence of quasi waves in anisotropic porous media”. J Acoust Soc Am. 2011 May;129(5):3302-16. doi: 10.1121/1.3557032.
  • Cowin SC, Cardoso L. “Fabric Dependence of bone ultrasound” Acta Bioeng Biomech. 2010;12(2):3-23.
  • Leong DJ, Li YH, Gu XI, Sun Li, Zhou Z, Nasser Ph, Laudier DM, Iqbal J, Majeska RJ, Schaffler MB, Goldring MB, Cardoso L, Zaidi M, Sun HB. “Physiologic loading of joints prevents cartilage degradation through CITED2”, FASEB J. 2011 Jan;25(1):182-91. doi: 10.1096/fj.10-164277. Epub 2010 Sep 8.
  • Rosenberger AL, Cooke SB, Rimoli R, Ni X, Cardoso L.  “First skull of Antillothrix bernensis, an extinct relict monkey from the Dominican Republic”. Proc Biol Sci. 2011 Jan 7;278(1702):67-74. doi: 10.1098/rspb.2010.1249. Epub 2010 Jul 21.
  • Herman BC, Cardoso L, Majeska RJ, Jepsen KJ, Schaffler MB. “Activation of bone remodeling after fatigue: Differential response to linear microcracks and diffuse damage”. Bone. 2010 Oct;47(4):766-72. doi: 10.1016/j.bone.2010.07.006. Epub 2010 Jul 12.
  • Cowin SC, Cardoso L. “Fabric dependence of wave propagation in anisotropic porous media”. Biomech Model Mechanobiol. 2011 Feb;10(1):39-65. doi: 10.1007/s10237-010-0217-7. Epub 2010 May 12.
  • Vengrenyuk Y, Kaplan TJ, Cardoso L, Randolph GJ, Weinbaum S. “Computational stress analysis of atherosclerotic plaques in ApoE knockout mice”. Ann Biomed Eng. 2010 Mar;38(3):738-47.
  • Leong DJ, Gu XI, Li Y, Lee JY, Laudier DM, Majeska RJ, Schaffler MB, Cardoso L, Sun HB.“Matrix Metalloproteinase-3 In Articular Cartilage Is Upregulated By Joint Immobilization And Suppressed By Passive Joint Motion" Matrix Biol. 2010 Jun;29(5):420-6. doi: 10.1016/j.matbio.2010.02.004. Epub 2010 Feb 12.
  • Gu XI, Leong DJ, Guzman F, Mahamud R, Li YH, Majeska RJ, Schaffler MB, Sun HB, Cardoso L. “Development and Validation of a Motion Loading System for a rat knee joint in vivo”. Ann Biomed Eng. 2010 Mar;38(3):621-31. doi: 10.1007/s10439-009-9865-0. Epub 2009 Dec 16.
  • Gailani G, Benalla M, Mahamud R, Cowin SC, Cardoso L. “Experimental Determination of the Permeability in the Lacunar-Canalicular Porosity of Bone”. J Biomech Eng. 2009 Oct;131(10):101007. doi: 10.1115/1.3200908.
  • Cardoso L, Herman BC, Verborgt O, Laudier D, Majeska RJ, Schaffler MB. “Osteocyte Apoptosis Controls Activation of Intracortical Resorption in Response to Bone Fatigue”. J Bone Miner Res. 2009 Apr;24(4):597-605. doi: 10.1359/jbmr.081210.
  • Cardoso L, Meunier A, Oddou C. “In vitro acoustic wave propagation in human and bovine cancellous bone as predicted by the Biot’s theory”. Journal of Mechanics in Medicine and Biology. 2008 8(2):1-19.
  • Vengrenyuk Y, Cardoso L, Weinbaum S. “Micro-CT Based Analysis of a New Paradigm for Vulnerable Plaque Rupture: Cellular Microcalcifications in Fibrous Caps” Mol Cell Biomech. 2008 Mar;5(1):37-47.
  • Choi BG, Vilahur G, Cardoso L, Fritton JC, Ibanez B, Zafar MU, Yadegar D, Speidl WS, Schaffler MB, Fuster V, Badimon JJ. “Ovariectomy increases vascular calcification via the OPG/RANKL cytokine signalling pathway”. Eur J Clin Invest. 2008 Apr;38(4):211-7. doi: 10.1111/j.1365-2362.2008.01930.x. Epub 2008 Feb 12.
  • Choi BG, Vilahur G, Zafar MU, Cardoso L, Yadegar D, Ibanez B, Tunstead J, Viles-Gonzalez JF, Schaffler MB, Fuster V, Badimon JJ. “Selective estrogen receptor modulation influences atherosclerotic plaque composition in a rabbit menopause model” Atherosclerosis. 2008 Nov;201(1):76-84. doi: 10.1016/j.atherosclerosis. 2008.01.017. Epub 2008 Feb 21.
  • Vengrenyuk Y, Carlier S, Xanthos S, Cardoso L, Ganatos P, Virmani R, Einav S, Gilchrist L, Weinbaum S. “A hypothesis for vulnerable plaque rupture due to stress-induced debonding around cellular microcalcifications in thin fibrous caps”. Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14678-83. Epub 2006 Sep 26.
  • Sun L, Peng Y, Sharrow AC, Iqbal J, Zhang Z, Papachristou DJ, Zaidi S, Zhu LL, Yaroslavskiy BB, Zhou H, Zallone A, Sairam MR, Kumar TR, Bo W, Braun J, Cardoso-Landa L, Schaffler MB, Moonga BS, Blair HC, Zaidi M. “FSH Directly Regulates Bone Mass”. Cell. 2006 Apr 21;125(2):247-60.
  • Cardoso L, Teboul F, Sedel L, Meunier A, Oddou C. “In Vitro Acoustic Waves Propagation in Human and Bovine Cancellous Bone.” J Bone Miner Res. 2003 Oct;18(10):1803-12.