Marilyn Gunner


Main Affiliation



Center for Discovery and Innovation







Marilyn Gunner


B.A., State Univ. of New York (Binghamton); Ph.D., Univ. of Pennsylvania 

Courses Taught

Physics 422 and Physics 732 Biophysics
Physics 203 Freshman Physics 

Research Interests

Molecular Biophysics & Structural Biology:
    PHYSICS: Electron transfer & proton transfer reactions 

Electron transfer & proton transfer reactions. Evaluating when and where electrostatic interactions are important in proteins.

″ Using time-resolved optical spectroscopy to study photosynthetic reaction centers. The aim is to characterize the energy landscape (reaction barriers and thermodynamics) of electron transfer reactions that are coupled to protein and proton motions.

″ Calculating pKs and electrochemical midpoints in proteins to see how a protein's form yields its function.

″ Developing MCCE which combines continuum electrostatics & molecular mechanics to study coupled conformation & ionization state changes in proteins.


Nielsen JE, Gunner MR, Garcia-Moreno BE The pKa Cooperative: a collaborative effort to advance structure-based calculations of pKa values and electrostatic effects in proteins., Proteins, doi: 10.1002/prot.23194 (2011).
CCNY Authors assigned: Gunner MR

Gunner MR, Zhu X, Klein MC MCCE analysis of the pK(a) s of introduced buried acids and bases in staphylococcal nuclease., Proteins, doi: 10.1002/prot.23124 (2011).
CCNY Authors assigned: Gunner MR, Zhu X, Klein MC

Madeo J, Mihajlovic M, Lazaridis T, Gunner MR. Slow Dissociation of a Charged Ligand: Analysis of the Primary Quinone Q(A) Site of Photosynthetic Bacterial Reaction Centers., J Am Chem Soc, DOI: 10.1021/ja205811f (2011).
CCNY Authors assigned: Madeo J, Mihajlovic M, Lazaridis T, Gunner MR.

Mielke SP, Kiang NY, Blankenship RE, Gunner MR, Mauzerall D. Efficiency of photosynthesis in a Chl d-utilizing cyanobacterium is comparable to or higher than that in Chl a-utilizing oxygenic species., Biochim Biophys Acta, 1807, 1231, doi:10.1016/j.bbabio.2011.06.007 (2011).
CCNY Authors assigned: Gunner MR

Rivalta I, Amin M, Luber S, Vassiliev S, Pokhrel R, Umena Y, Kawakami K, Shen JR, Kamiya N, Bruce D, Brudvig GW, Gunner MR, Batista VS. Structural-functional role of chloride in photosystem II., Biochemistry, 50, 6312 DOI: 10.1021/bi200685w (2011).
CCNY Authors assigned: Amin M, Gunner MR

Blankenship RE, Tiede DM, Barber J, Brudvig GW, Fleming G, Ghirardi M, Gunner MR, Junge W, Kramer DM, Melis A, Moore TA, Moser CC, Nocera DG, Nozik AJ, Ort DR, Parson WW, Prince RC, Sayre RT. Comparing photosynthetic and photovoltaic efficiencies and recognizing the potential for improvement., Science, 332, 805-809 DOI: 10.1126/science.1200165 (2011).
CCNY Authors assigned: Gunner MR

Gunner MR How proteins control tunneling pathways by tuning cofactor electrochemistry, ACS Session 20 years of Tunneling Pathways, Anaheim CA (2011).
CCNY Authors assigned: Gunner MR

Gunner MR Kinetic vs. Thermodynamic Control of Bacteriorhodopsin, APS March Meeting 2011, Dallas (2011).
CCNY Authors assigned: Gunner MR

Gunner MR Evolution's design for solar energy capture: What we can learn from natural photosynthesis, 7th International Conference on Biological Physics, San Diego (2011).
CCNY Authors assigned: Gunner MR

Zheng, Z., Dutton, P.L. and Gunner, M.R The measured and calculated affinity of methyl- and methoxy-substituted benzoquinones for the Q(A) site of bacterial reaction centers, Proteins, 78(12), 2638-54 (2010).
CCNY Authors assigned: Zheng Z, Gunner MR

Zhang J, Gunner MR Multiconformation continuum electrostatics analysis of the effects of a buried Asp introduced near heme a in Rhodobacter sphaeroides cytochrome c oxidase., Biochemistry, 49(37), 8043-52 (2010).
CCNY Authors assigned: Zhang J, Gunner MR