Mark R. Biscoe


Main Affiliation

Chemistry and Biochemistry

Areas of Expertise/Research

  • Chemistry


Center for Discovery and Innovation







Mark R. Biscoe


Massachusetts Institute of Technology (NIH post-doctoral fellow) 2005-2008

Columbia University, Ph.D., 2005

Wesleyan University, B.A., 1999

Research Interests


17. Li, Ling; Biscoe, Mark R. "Alkylzinc Cross-Coupling Reactions." In Cross-Coupling and Heck-Type Reactions, Vol. 1; Molander, G., Ed.; Georg Thieme Verlag HG: Stuttgart, 2012.

16. Joshi-Pangu, Amruta; Ma, Xinghua; Diane, Mohammed; Iqbal, Sidra; Kribs, Robert J.; Huang, Richard; Wang, Chao-Yuan; Biscoe, Mark R.J. Org. Chem. 201277, 6629-6633.

15. Joshi-Pangu, Amruta; Biscoe, Mark R.* "The Use of Tertiary Alkyl Nucleophiles in Metal-Catalyzed Cross-Coupling Reactions." Synlett2012, 23, 1103-1107. [Invited review highlighting work in publication 14]

14. Joshi-Pangu, Amruta; Wang, Chao-Yuan; Biscoe, Mark R.* “Nickel-Catalyzed Kumada Cross-Coupling Reactions of Tertiary Alkylmagnesium Halides and Aryl Bromides/Triflates.” J. Am. Chem. Soc. 2011133, 8478-8481. [Highlighted in: Synfacts 20118, 897]

13. Joshi-Pangu, Amruta; Ganesh, Madhu; Biscoe, Mark R.* “Nickel-Catalyzed Negishi Cross-Coupling Reactions of Secondary Alkylzinc Halides and Aryl Iodides.” Org. Lett. 201113, 1218-1221. [Highlighted in: Synfacts 20116, 662] 

12. Biscoe, Mark R.; Buchwald, Stephen L. “The Selective Monoarylation of Acetate Esters and Aryl Methyl Ketones Using Aryl Chlorides.”Org. Lett. 200911, 1773-1775. 

11. Lee, Brian K.; Biscoe, Mark R.; Buchwald, Stephen L. “Simple, Efficient Protocols for the Pd-Catalyzed Cross-Coupling Reaction of Aryl Chlorides and Dimethylamine.” Tetrahedron Lett. 200950, 3672-3674 [50th anniversary special issue]. 

10. Fors, Brett P.; Watson, Donald A.; Biscoe, Mark R.; Buchwald, Stephen L. “A Highly Active Catalyst for Pd-Catalyzed Amination Reactions: Cross-Coupling Reactions Using Aryl Mesylates and the Highly Selective Monoarylation of Primary Amines.” J. Am. Chem. Soc.2008130, 13552-13554. 

9. Biscoe, Mark R.; Fors, Brett P.; Buchwald, Stephen L. “A New Class of Easily Activated Palladium Precatalysts for Facile C–N Cross-Coupling Reactions and the Low Temperature Oxidative Addition of Aryl Chlorides.” J. Am. Chem. Soc. 2008130, 6686-6687. [Featured as Editor’s Choice in: Science 2008320, 850-851] 

8. Biscoe, Mark R.; Barder, Timothy E.; Buchwald, Stephen L. “Electronic Effects on the Selectivity of Pd-Catalyzed C–N Bond-Forming Reactions Using Biarylphosphine Ligands: The Competitve Roles of Amine Binding and Acidity.” Angew. Chem. Int. Ed. 200746, 7232-7235. 

7. Ikawa, Takashi; Barder, Timothy E.; Biscoe, Mark R.; Buchwald, Stephen L. “Pd-Catalyzed Amidations of Aryl Chlorides Using Monodentate Biaryl Phosphine Ligands: A Kinetic, Computational, and Synthetic Investigation.” J. Am. Chem. Soc. 2007129, 13001-13007. 

6. Barder, Timothy E.; Biscoe, Mark R.; Buchwald, Stephen L. “Structural Insights into Active Catalyst Structures and Oxidative Addition to (Biaryl)phosphine-Palladium Complexes via Density Functional Theory and Experimental Studies.” Organometallics 200726, 2183-2192. 

5. Uyeda, Christopher; Biscoe, Mark; Leplae, Paul; Breslow, Ronald. “Hydrophobically-Directed Selective Reduction of Ketones Using Amine Boranes.” Tetrahedron Lett. 200647, 127-130. 

4. Biscoe, Mark R.; Breslow, Ronald. “Oxaziridinium Salts as Hydrophobic Epoxidation Reagents: Remarkable Hydrophobically-Directed Selectivity in Olefin Epoxidation.” J. Am. Chem. Soc. 2005127, 10812-10813. 

3. Biscoe, Mark R.; Uyeda, Christopher; Breslow, Ronald. “Requirements for Selective Hydrophobic Acceleration in the Reduction of Ketones.” Org. Lett. 20046, 4331-4334.   

2. Biscoe, Mark R.; Breslow, Ronald. “Hydrophobically-Directed Selective Reduction of Ketones.” J. Am. Chem. Soc. 2003125, 12718-12719.   

1. Biscoe, M. R.; Fry, A. J. “Dual Reaction Pathways in the Magnesium-Mediated Synthesis of Aziridines from Benzal Halides and Imines.”Tetrahedron Lett. 200142, 2759-2762.