Padmanava Pradhan

Director, Nuclear Magnetic Resonance Facility

Scientific Research utilizing Nuclear Magnetic Resonance Spectroscopy

Main Affiliation

Chemistry and Biochemistry

Building

Marshak Science Building

Office

1236

Phone

212-650 8266

Fax

212-650-6107

Email

ppradhan@ccny.cuny.edu

Padmanava Pradhan

Publications in peer-reviewed Science Journals.

  1. W. Wei, R.  Khangarot, L. Stahl, Lothar, C. Veresmortean, P.  Pradhan, L. Yang, and B. Zajc. (2018). Generating Stereodiversity: Diastereoselective Fluorination and Highly Diastereoselective Epimerization of α-Amino Acid Building Blocks. Organic Letters. 20. 10.1021. 
  2. O.  Zacarias, W. Aguilar, M. M.  Paz S. Tsukanov. M. Zheng, S-Y. Cheng, P. Pradhan and E. Champeil. (2018) Isolation and Rationale for the Formation of Isomeric Decarbamoylmitomycin C-N6-deoxyadenosine Adducts in DNA. Chem. Res. Toxicol. 31(8), 762-771.
  3. S. Christian, P. Pradhan and U.  Jans. (2018) Investigation of the Nucleophilic Attack of Dichlorvos by Reduced Sulfur Species Using 1H NMR. J. Agric. Food Chem. 66, 424-431. 
  4. M.  R. Andrzejewska, P. K. Vuram, N. Pottabathini, V. Gurram, S. V. Relangi, K. A. Korvinson, R. Doddipalla, L. Stahl,M. C. Neary, P. Pradhan, S. Sharma and M. K. Lakshman. (2018) The Disappearing Director: The Case of Directed N‐Arylation via a Removable Hydroxyl Group.  Adv. Synth.  Cat, 160 (13), 1-9.
  5. S. Satishkumar, S. Poudapally, P. K. Vuram, V. Gurram, N. Pottabathini, D. Sebastian, L. Yang, P. Pradhan, M. K. Lakshman , Pd-Catalyzed versus Uncatalyzed, PhI(OAc)2-Mediated Cyclization Reactions of N6-([1,1′-Biaryl]-2-yl)Adenine Nucleosides, ChemCatChem 2017, 9(21), 4058-4069.
  6. S. Banerjee, S. Sihna, P. Pradhan, A. Caruso, D. Liebowitz, D. Parrisj, M. Rossi, and B. Zajc. Regiospecifically Fluorinated Polycyclic Aromatic Hydrocarbons via Julia–Kocienski Olefination and Oxidative Photocyclization. Effect of Fluorine Atom Substitution on Molecular Shape. J. Org. Chem., 2016, 81 (10), pp 3983– 399.
  7. Basava, V.; Yang, L.; Pradhan, P.; Lakshman, M. K.: A novel bis(pinacolato)diboron-mediated N–O bond deoxygenative route to C6 benzotriazolyl purine nucleoside derivatives, Organic and Bimolecular Chemistry 2016, 14, 7069–7083. 
  8. P. F. Thomson, D. Parrish, P. Pradhan, and M. K. Lakshman: Modular, Metal-Catalyzed Cycloisomerization Approach to Angularly Fused Polycyclic Aromatic Hydrocarbons and Their Oxidized Derivatives. J. Org. Chem., 2015, 80 (15), 7435–7446.
  9. Yedulla, V. R.; Pradhan, P.; Yang, L.; Lakshman, M. K.: Cycloaddition of arynes and cyclic enol ethers as a platform for access to stereochemically defined, 1,2-disubstituted benzocyclobutenes, European J. Org. Chem., 2015, 750–764. 
  10. R.R. Chamala, D. Parrish ,P. Pradhan, and M. K. Lakshman Purinyl N1-Directed Aromatic C–H Oxidation in 6-Arylpurines and 6-Arylpurine Nucleosides (2013) J. Org. Chem., 2013, 78 (15), pp 7423–7435.
  11. AK. Parhi, Y. Zhang, K.W. Saionz, P.Pradhan, M. Kaul, K.Trivedi, D.S. Pilch, E. J. LaVoie. Antibacterial activity of quinoxalines, quinazolines, and 1,5- naphthyridines. (2013) Bioorg. & Med. Chem.Letts, 23(17): 4968-4974.
  12. T. Butkhuzi; M. Kurtanidze; R. Chaladze; M. Gvaramia; M. Rukhadze; G. Bezarashvili; K. Sigua; P. Pradhan. Investigation of influence of nonionic additives on structural changes of water droplets encapsulated in AOT reverse micelles by instrumental methods in: Colloids and Surface A: Physiochemical and Engineering Aspects. (2014), 460, pp-123-129
  13. A. L. M. Reddy, P. Chumyim,, S. R. Gowda, N. Subbiah, P. Pradhan, S. R. Jadhav,  M. Dubey, G. John and P. M. Ajayan. Lithium storage mechanisms in purpurin based organic lithium ion battery electrode (2012) Nature Science Reports 2: 960 doi:10.1038/srep00960. [View Entrez Listing]
  14. M. K. Lakshman, A. Deb, R. R. Chamala, P. Pradhan, R. Pratap. Direct arylation of 6-phenylpurine and 6-arylpurine nucleosides by ruthenium-catalyzed C-H bond activation. Angewandte Chemie, International Edition 2011, 50, 11400-11404. DOI: 10.1002/anie.201104035. [View Entrez Listing]
  15. R. Kumar, P. Pradhan and B. Zajc. Facile synthesis of 4-vinyl- and 4-fluorovinyl-1, 2, 3-triazoles via bifunctional “click-olefination” reagents. (2011)  Chem. Commun. 47, 3891-3893. doi: 10.1039/c0cc05083k. Epub 2011 Feb 18. [View Entrez Listing]
  16. V.S. Balachandran, S. R. Jadhav, P. Pradhan, S. De Carlo and G. John. Adhesive Vesicles through Adaptive Response of a Biobased Surfactant. (2010). Angew. Chem. Int. Ed. 4, 9509. [View Entrez Listing]
  17. Synthesis of N6,N6-Dialkyladenine Nucleosides Using Hexaalkylphosphorus Triamides Produced in Situ. M. K. Lakshman  A. Choudhury, S. Bae, E. Rochttis, P. Pradhan, A. Kumar (2009) Eur. J. Org. Chem. 152-159. 
  18. Palladium-Catalyzed Synthesis of Nucleoside Adducts from Bay and Fjord Region Diol Epoxides. E. Champeil, P. Pradhan and M. K. Lakshman (2007) J. Org. Chem. 72(14) pp 5035 – 5045. [View Entrez Listing]
  19. Highly diastereoselective synthesis of nucleoside adducts from the carcinogenic benzo[a]pyrene diol epoxide and a computational analysis. M. K. Lakshman, J. C. Keeler, F. N. Ngassa, J. H. Hilmer, P. Pradhan, B. Zajc and K. A. Thomasson (2007) J. Am. Chem. Soc., 129, 68-76. [View Entrez Listing]
  20.  Voltage gating and anions, especially phosphate: A model peptide. P. Pradhan, R. Ghose and M. E. Green (2005) Biochim. Biophys Acta. 1717, 97-103. [View Entrez Listing]
  21. Mild and room temperature C-C bond forming reactions of nucleoside C-6 arylsulfonates. M. K. Lakshman,  P. Gunda and P. Pradhan (2005)  J. Org. Chem.70(25):10329-35.[View Entrez Listing]
  22. Synthesis and Reactions of 2-Chloro- and 2-Tosyloxy-2'-deoxyinosine Derivatives. N. Pottabathini,  S. Bae, P. Pradhan,  H. Hanh, H.  Mah and M. Lakshman (2005). J. Org. Chem. 70(18); 7188-7195. [View Entrez Listing]
  23. NMR Solution Structure of an 1,2-d(GG) Intrastrand  Cross-lonk in a DNA Dodecamer Complex. Y. Yu, P. Pradhan, J. Havener, G. Boysen, J. A. Swenberg, S. L. Campbell, S. G. Chaney (2004) J. Mol. Biol. 341(5), 1251-69.[View Entrez Listing]
  24. Mutagenesis of the Runt Domain Defines Two Energetic Hot Spots for Heterodimerization with the Core Binding Factor Subunit.  Lina Zhang , Zhe Li , Jiangli Yan , Padmanava Pradhan , Takeshi Corpora, Matthew D. Cheney , Jerónimo Bravo, Alan J. Warren, John H. Bushweller and Nancy A. Speck (2003) J. Biol. Chem., 278, Issue 35, 33097-33104. [View Entrez Listing]
  25. A novel intramolecular arene–alkene photocycloaddition in 2-alkenyl naphtha-4-chromanones––a short route to functionalised multicyclic systems.  Govind P. Kalenaa, Padmanava Pradhana, Vedavati S. Puranikb and Asoke Banerji (2003) Tetrahedron Letters, 44, 2011-2013. [View Science Direct Listing]
  26. MQ-HCN-based Pulse Sequences for the Measurement of C1'-H1', C1'-N, H1'-N,C1'-C2', H1'-C2', C6/8-H6/8, C6/8-N, H6/8-N, C6-C5, H6-C5 Dipolar Couplings in 13C,15N-labeled DNA (and RNA).  Jiangli Yan, Takeshi Corpora, Padmanava Pradhan, and John H. Bushweller (2001) J. Biomol. NMR, 22, 9-20. [View Entrez Listing]
  27. Solution Structure of a Trans Opened (10S)-dA Adduct of (+)-(7S,8R,9S,10R)-7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in a Fully Complementary DNA Duplex:  Evidence for a Major Syn Conformation; P. Pradhan, S. Tirumala, X. Liu, J. Sayer, D. M. Jerina and H. J. C. Yeh. Biochemistry. 40, 5770-5881 (2001). [View Entrez Listing]
  28.  “NMR Solution Structures of Undecanucleotide Duplexes with Thymidine Base Opposite (10R)‑Adducts Derived from Trans Addition of Deoxyadenosine N6‑Amino Group to (‑)‑(9R,10S)‑9,10‑epoxy‑7,8,9,10‑ tetrahydrobenzo[a]pyrene and its (‑)‑ (7S,8R,9R,10S)‑7,8‑Dihydroxy analogue”; P. Pradhan, X. Liu, J. Sayer, M. K. Lakshman, J. H. Shah, D. M. Jerina and H. J. C. Yeh. (manuscript).
  29. Solution Conformations and Base Pair Opening Dynamics of the trans N2-dG adduct derived from 10S (+)-anti-Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide and 5'-d(CCTATAGATATCC).d(GGATATCTATAGG), a 13-mer oligonucleotide duplex; P. Pradhan, B. Jernström, A. Seidel, M. Leijon and A. Gräslund (manuscript)
  30. Implications of Cytosine Methylation on (+)-anti-benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide N2-dG Adduct formation in 5'-d(CGT), 5'-d(CGA) and 5'-d(CGC)  sequence contexts of single- and double-Stranded oligonucleotides; P. Pradhan, A. Gräslund, A. Seidel, and B. Jernström, Chem. Res. Toxicol.  12, 816-821 (1999). [View Entrez Listing]  
  31. Stereo- and Regioselectivity of Intramolecular 1,2-Aren-Alkene Photocycloaddition in 2-Alkenyl-4-Chromanones; G. P. Kalena, P. Pradhan, and A. Banerji, Tetrahedron (spl. issue). 55, 3209-3218 (1999).[View Science Direct Listing]
  32. Studies on the adduct heterogeneity of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide stereoisomers covalently bound to deoxyribooligonucleotides by induced circular dichroism and uv absorption spectroscopy; P. Pradhan, B. Jernström, A. Seidel, B. Nordén and A. Gräslund. Chem. Res. Toxicol.  12, 403-411 (1999). [View Entrez Listing]
  33. Studies on adduct formation of (+)-anti-benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide with 5'- d(CCTATCGTTATCC) and 5'- d(CCTATCm5GTTATCC) oligonucleotides; P. Pradhan, A. Gräslund, A. seidel and B. Jernström. Polycyclic Aromatic Hydrocarbons. 17, 21-32 (1999).
  34. Induced circular dichroism of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide stereoisomers covalently bound to deoxyribooligonucleotides and equilibrium dynamics between groove binding and intercalative binding conformations; P. Pradhan, B. Jernström, A. Seidel, B. Nordén and A. Gräslund. Biochemistry. 37, 4664-4673 (1998). [View Entrez Listing]
  35. Novel Cyclobutane fused Furochromone Oligomers from the seeds of Pimpinella monoica Dalz; P. Pradhan and A. Banerji, Tetrahedron. 54, 14541-14548 (1998).[View Science Direct Listing]
  36. Intramolecular Photorearrangement of a 2-alkenyl-4-chromanone to an oxapentacyclotetradecanedione; G. P. Kalena, P. Pradhan, Swarnalata,T. P Singh, and Asoke Banerji, Tetrahedron Letts. 38, 5551-5554 (1997).[View Science Direct Listing]
  37. Stereochmical Assignment of Tertiary Hydroxyl Group in Diterpene Furan Glycosides by Pyridine Induced Shifts, 13C- and 2D-NMR Spectroscopy; P. Pradhan, Vijay D. Gangan, Arjun. T. Sipahimalani and Asoke. Banerji, Spectroscopy Letts. 30(7), 1467-1474  (1997).
  38. Stereochemistry of Diastereomeric Neolignans from Piper hookeri by NMR spectroscopy; P. Pradhan and A. Banerji, Phytochemical Analysis. 9(2), 71-74 (1997).
  39. Electron donor-acceptor interactions of C60 ,with n- and p-donors: A rational approach towards its solubility; S. Talukdar, P. Pradhan and A. Banerji, Full. Sc. & Tech. 5 (3), 547-557 (1997).
  40. N-trans-feruloyltyramine from Tinospora cordifolia, V. D. Gangan, P. Pradhan, A. T. Sipahimalani et.al; Ind. J. Chem.Sect.B., 36B, 837-839 (1997). 894-898 (1993).
  41. Multinuclear Magnetic Resonance Studies of Aluminium Chelates Part I: Chelates with Catechol and Tiron; S. N. Mhatre, S. B. Karweer, P. Pradhan, R. K. Iyer and P. N. Moorty; J. Chem. Soc. Dalton Trans. 3711-3716 (1994).[View Entrez Listing]
  42. Two New Norditerpene Furan Glycosides from Tinospora cordifolia; V. D. Gangan, P. Pradhan, A. T. Sipahimalani and A. Banerji; Phytochemistry, 39, 1139-1142 (1995).[View Science Direct Listing]
  43. Cordifolisides A, B, C: Furanoid Norditerpene glycosides from Tinospora cordifolia; V. D. Gangan, P. Pradhan, A. T. Sipahimalani and A. Banerji; Phytochemistry, 37, 781-786 (1994). [View Entrez Listing]
  44. Pimolin, A New Class of Natural Products, A Naturally Occuring Furochromone Dimer from Pimpinella monoica; P. Pradhan, D. L. Luthria and A. Banerji; Bio Org. and Med. Chem. Letts. 4, 2425 – 2428 (1994).[View Science Direct Listing]
  45. (1a, 3a,11a)-2,2,11-trimethyl-14-oxatetra-cyclo[6.5.0.17,11.03,8]tetradec-6-ene-5,9-dione; V. Kabaleswaran, S. S. Rajan, G. P. Kalena, P. Pradhan and A. Banerji, Acta. Cryst. Sec. C. C51, 1981-1883 (1996).
  46. Phytoecdysones from Tinospora cordifolia: Structural elucidation of ecdysterone and makisterone A by 2D NMR spectroscopy; V. D. Gangan, P. Pradhan and A. T. Sipahimalani; Ind. J. Chem.Sect.B. 36B, 787-792 (1997).[View Science Direct Listing]
  47. Palmitosides C and F: Furan Diterpene Glycosides from Tinospora cordifolia: Structural Elucidation by 2D NMR Spectroscopy; V. D. Gangan, P. Pradhan, A. T. Sipahimalani and A. Banerji; Ind. J. Chem.Sect.B, 35B, 630-634 (1996).
  48.  Neolignans  of Indian Piper species: structure of hookerinone A, a novel neolignan; P. Pradhan, S. J. Desai, L. P. Badheka and A. Banerji, Nat. Prod. Letts. 4, 35-42 (1994).
  49. Tomentonone, a new xanthonoid from the stem bark of Calophyllum tomentosum; A. Banerji, A. D. Deshpande, B. R. Prabhu and P. Pradhan; J. Nat. Prod. 57, 396-399 (1994).
  50. Stereochemistry of a guaianolide from Cyathocline purpurea by high resolution NMR; P. Pradhan, G. J. Chintalwar and A. Banerji; Spectroscopy Letts. 26, 997-1004 (1993).
  51. B. K. Mishra, S. D. Samant. P. Pradhan, S. B. Mishra and C.Manohar, A new strongly flow birefringent surfactant system. Langmuir 9 894 (1993)
  52. A novel intramolecular 1,2-arene-alkene photocycloaddition; G. P. Kalena, P. Pradhan and A. Banerji; Tetrahedron Letts. 33, 7775-7778 (1992) .
  53.  Structure of zeyloxanthonone (wightianone) - A reinvestigation; A. Banerji, A. D. Deshpande and  P. Pradhan, Tetrahedron Lett.; 32, 4995-4998 (1991).[View Science Direct Listing]
  54. Methyl Picrotoxate, A minor component of berries of plant Anamirta cocculus and its stereochemistry by high resolution NMR spectroscopy; P. Pradhan, A.T.  Sipahimalani, and V.R. Mamdapur; Indian J.Chem. Sect.B. 29B, 676-677 (1990).
  55. Two Phytoecdysones from Tinospora cordifolia: Structural Assignments by 2D NMR spectroscopy; P. Pradhan, V. D. Gangan, A. T. Sipahimalani and A. Banerji, Ind. J. Chem.Sect.B., 36B, 958-962 (1997).
  56. 2D-NMR spectroscopy in structure elucidation of natural products;  A.  Banerji, A. D.  Deshpande, D. L. Luthria and P. Pradhan; Proceedings of the symposium on natural product chemistry; Peredenia University, Srilanka, 1991.
  57.  Piperaceae Alkaloids from Piper hookeri: Revision of NMR Assignments by the Application of 2D NMR Spectroscopy; P. Pradhan, V. D. Gangan, L. P. Badheka and A. Banerji, Indian J.Chem. Sect.B (manuscript).
  58. Multinuclear Magnetic Resonance Studies on Aluminium Chelates. Part II. Chelates with 2-Hydroxybenzoic Acid and 3-Carboxy-4-hydroxybenzene Sulphonic Acid; R. K. Iyer, S. N. Mhatre; P. Pradhan and P. N. Moorthy. (manuscript).
  59.   “Novel multicyclic compounds via intramolecular arene alkene photocyclisation”. P. Pradhan, G. Kalena and A. Banerji.In New Horizons in Organic Synthesis, Eds. V. Nair and S. Kumar, New Age International (P) Ltd. Publishers, New Delhi (1997); p. 222-227.