Reza Khayat

Assistant Professor

Areas of Expertise/Research

  • Mechanisms of Host Pathogen Interactions
  • Therapeutic Molecules


Center for Discovery and Innovation







Reza Khayat


Ph.D., Columbia U.  2003

M.S.,  Columbia U.  2000

B.S.,  U. of California, Irvine  1998

Courses Taught

Chem 45902: Biochemistry 1

Research Interests

My research goal is to understand the life-cycle of DNA viruses at an atomic resolution. In particular we seek to characterize the mechanisms by which these viruses identify their hosts, acquire entry into the cell, modify the cellular cytoskeleton, deliver their genomes to the nucleus, replicate, assemble and egress from the cell. We use a combination of biochemistry, biophysics, X-ray crystallography and cryo-electron microscopy to address these topics.


35. Murin CD, Julien JP, Sok D, Stanfield RL, Khayat R, Cupo A, Moore JP, Burton DR, Wilson IA, Ward AB. Structure of 2G12 Fab2 in Complex with Soluble and Fully Glycosylated HIV-1 Env by Negative-Stain Single Particle Electron Microscopy. J. Virology 2014 Sep 1;88(17):10177-88.

34. Veesler D, Khayat R, Krishnamurthy S, Snijder J, Huang RK, Heck AJ, Anand GS, Johnson JE. Architecture of a dsDNA Viral Capsid in Complex with Its Maturation Protease. Structure. 2014 Feb 4;22(2):230-7.

33. Klasse PJ, Depetris RS, Pejchal R, Julien JP, Khayat R, Lee JH, Marozsan AJ, Cupo A, Cocco N, Korzun J, Yasmeen A, Ward AB, Wilson IA, Sanders RW, Moore JP. Influences on trimerization and aggregation of soluble, cleaved HIV-1 SOSIP envelope glycoprotein. J. Virology 2013 Jul 3.

32. Khayat R, Lee JH, Julien JP, Cupo A, Klasse PJ, Sanders RW, Moore JP, Wilson IA, Ward AB. Structural characterization of cleaved, soluble human immunodeficiency virus type-1 envelope glycoprotein trimers. J. Virology 2013 Jul 3.

31. Kong L, Lee JH, Doores KJ, Murin CD, Julien JP, McBride R, Liu Y, Marozsan A, Cupo A, Klasse PJ, Hoffenberg S, Caulfield M, King CR, Hua Y, Le KM, Khayat R, Deller MC, Clayton T, Tien H, Feizi T, Sanders RW, Paulson JC, Moore JP, Stanfield RL, Burton DR, Ward AB, Wilson IA. Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120. Nat. Struct. Mol. Biol. 2013 Jul;20(7):796-803.

30. Julien JP, Sok D, Khayat R, Lee JH, Doores KJ, Walker LM, Ramos A, Diwanji DC, Pejchal R, Cupo A, Katpally U, Depetris RS, Stanfield RL, McBride R, Marozsan AJ, Paulson JC, Sanders RW, Moore JP, Burton DR, Poignard P, Ward AB, Wilson IA. Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans. PLoS Pathogens 2013 May;9(5):e1003342.