Robert Tycko, NIH Distinguished Investigator, Laboratory of Chemical Physics, NIDDK, NIH, Bethesda, MD, will give a talk on "New Problems for Solid State NMR in Biomolecular Physics."

This seminar will also be available by Zoom. Zoom link: https://gc-cuny.zoom.us/j/96975997619?pwd=C4JXA4s7H3L4sgnmmpWmoHdCunxLbe.1

Meeting ID: 969 7599 7619. Passcode: asrc**ccny

Please note: 

* Full names must be used to be admitted to the Zoom meeting.

* The Zoom meeting will be closed and locked at 12:15 p.m., and no one will be able to enter the meeting after that time.

ABSTRACT

My lab develops new methods for NMR studies of biomolecular systems and applies them to a variety of problems, often in combination with electron microscopy and other techniques.  This seminar will focus on two recent projects: (1) Time-resolved NMR measurements with millisecond time resolution, based on novel equipment for rapid mixing, rapid temperature jumps, rapid freezing, and ultra-low-temperature solid state NMR.  Results from studies of protein folding and amyloid-β peptide oligomerization will be presented; (2) A new approach to NMR studies of nanopore-confined peptides and proteins, based on nanoporous anodic aluminum oxide (AAO) and surface attachment through phosphonic acid/aluminum oxide chemistry.  These studies aim to elucidate how nanopore confinement affects the conformations, dynamics, and interactions of intrinsically disordered FG-repeat protein sequences, which fill the central channels of nuclear pore complexes in eukaryotic cells.