Neil L. Kelleher, Professor of Molecular Biosciences, Professor of Chemistry, Professor of Medicine at Northwestern University, Evanston, IL, will give a talk titled, "Digitizing Proteoform Biology with Single Molecule & Single Cell Mass Spectrometry."

This seminar will only be available by Zoom. Zoom link https://gc-cuny.zoom.us/j/99611592897.  Meeting ID:  996 1159 2897.  Passcode:  asrc+CCNY

Please note: 

* Full names must be used to be admitted to the Zoom meeting.

* The Zoom meeting will be closed and locked at 12:15 p.m., and no one will be able to enter the meeting after that time.

ABSTRACT

Since the completion of the Human Genome Project, much has been made of the need to bridge the gap from genes and traits. As a key nexus for the many interacting ‘-omes’ (genome, transcriptome, proteome, metabolome, etc.), the proteome should offer a tight link between genotype and phenotype. Proteoforms, or all of the precise molecular forms of a protein, capture all sources of variability in protein composition (i.e., SNPs, isoforms, post-translational modifications), and thus provide crucial insights into regulation and function. Now, “single ion” mass spectrometry is poised to convert genes to proteoform signatures at a far faster rate. Recently we developed proteoform imaging mass spectrometry (PiMS), with individual ion mass spectrometry. This platform has been extended now to single-cell Proteoform imaging Mass Spectrometry (scPiMS), boosting cell processing rates by >20-fold in the field while detecting proteoforms from single cells.