Rupal Gupta, Associate Professor, Department of Chemistry, College of Staten Island, Staten Island, NY, will give a talk titled, "Structure, Dynamics, and Assembly of Human Antimicrobial Proteins."

This seminar will also be available by Zoom. Zoom link: Join Zoom Meeting
https://gc-cuny.zoom.us/j/91607074885?pwd=3peeVNPa5kUJJ48m7lObDWLl3SQ1n… ; Meeting ID 916 0707 4885.  Passcode:  ASRCccny

Please note: 

* Full names must be used to be admitted to the Zoom meeting.

* The Zoom meeting will be closed and locked at 12:15 p.m., and no one will be able to enter the meeting after that time.

ABSTRACT

Antimicrobial proteins in humans sequester zinc to curtail infection. Although well established as key components of the immune response, the mechanisms of action of these proteins, such as S100A12, in the inflammatory pathway is not well understood. In this talk, I will present our work on biophysical characterization of S100A12 using NMR spectroscopy, together with cellular studies evaluating the origin of inflammatory signals triggered by the protein. In particular, I will focus on the roles of Ca(II) and Zn(II) towards modulating the structure and internal dynamics of S100A12 that afford its biological functions. Based on our studies, we propose a generalized model describing the molecular events that enable S100A12 and related antimicrobial proteins to regulate infection and inflammation during immune response.