Biochemistry Seminar: Kathryn Wellen, "Metabolic compartmentalization and adaptations in cancer"

Wed, Oct 20, 2021 - 12:00 PM — Wed, Oct 20, 2021 - 01:00 PM
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Meeting ID: 495 404 8198


Kathryn Wellen, Associate Professor, Dept. of Cancer Biology, University of Pennsylvania Perelman School of Medicine, will give a talk on "Metabolic compartmentalization and adaptations in cancer."


Cells continually monitor nutrient availability to adapt to their environment and to inform decisions about survival, proliferation, and performance of different functions.  Accordingly, many metabolites play crucial roles as signaling molecules, in addition to their functions in energy production and biosynthesis.  In this presentation, I will discuss two projects.  In the first, I will discuss the application of new methods to assess metabolism in sub-cellular compartments such as the nucleus to glean new insights into mechanisms of crosstalk between metabolism and the epigenome.  In the second, I will discuss evidence for engagement of a hexosamine salvage mechanism that cancer cells employ in the face of nutrient deprivation in the tumor microenvironment.

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