Biochemistry Seminar: Pilar Cossio, "Free energies from cryoEM particles"

Wed, Feb 08, 2023 - 12:00 PM — Wed, Feb 08, 2023 - 01:00 PM
Admission Fee
Free. Coffee & tea will be available in the ASRC Cafe at 11:30 AM
Event Address
The speaker will be in-person:
ASRC Main Auditorium
85 Saint Nicholas Terrace
Current CUNY Cleared4 Pass is required for entrance; masks are optional.
Phone Number
Event Location
The seminar can also be viewed via Zoom.
Zoom link:
Passcode: ASRC-CDI
Event Details

Pilar Cossio, Research Scientist and Project Leader for Structural and Molecular Biophysics at the Flatiron Institute Center for Computational Mathematics, will give a talk on "Free energies from cryoEM particles."


Cryo-electron microscopy (cryo-EM) is an experimental technique that measures single-particle projections of biomolecules. Although single-particle cryo-EM is widely used for 3D reconstruction, it has the potential to provide information about a biomolecule’s conformational variability and provide quantitative measurements of probability distributions. However, cryo-EM images are challenging to analyze due to their low signal-to-noise ratio. To address these issues, we developed mathematical methods to infer free-energy profiles and their uncertainties from cryo-EM raw images.

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